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Displaying results 1061 - 1070 of 2256 in total
  1. Target

    Oncostatin-M-specific receptor subunit beta

    go.drugbank.com/bio_entities/BE0018846
    TargetHumans

    In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (PubMed:15627637) … Functions as a shared membrane-bound signal-transducing subunit in two distinct receptor complexes, the type II OSM receptor (heterodimer composed of OSMR and IL6ST) and the IL31 receptor complex (heterodimer

    Polypeptides: Oncostatin-M-specific receptor subunit betaSynonyms: IL-31 receptor subunit beta, Interleukin-31 receptor subunit beta
  2. Target

    Taste receptor type 2 member 4

    go.drugbank.com/bio_entities/BE0020472
    TargetHumans

    Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.

    Polypeptides: Taste receptor type 2 member 4Function: bitter taste receptor activity
  3. Target

    Short transient receptor potential channel 6

    go.drugbank.com/bio_entities/BE0020965
    TargetHumans

    Mediates calcium entry following G(q)-coupled receptor or receptor tyrosine kinase activation, which triggers phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositides and production of diacylglycerol … Mediates depolarization of intrinsically photosensitive retinal ganglion cells (ipRGCs) in response to light-induced melanopsin (OPN4)-mediated phototransduction via G(q)-PLC signaling, likely by forming

    Polypeptides: Short transient receptor potential channel 6Synonyms: Transient receptor protein 6
  4. Target

    Neuropeptide Y receptor type 4-2

    go.drugbank.com/bio_entities/BE0024014
    TargetHumans

    G protein-coupled receptor for PPY/pancreatic polypeptide/PP, NPY/neuropeptide Y and PYY/peptide YY that is negatively coupled to cAMP.

    Polypeptides: Neuropeptide Y receptor type 4-2Function: pancreatic polypeptide receptor activity
  5. Target

    T cell receptor gamma variable 9

    go.drugbank.com/bio_entities/BE0025222
    TargetHumans

    V region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447).

    Polypeptides: T cell receptor gamma variable 9
  6. Drug

    Etoperidone

    go.drugbank.com/drugs/DB09194
    ApprovedWithdrawn

    Etoperidone is an atypical antidepressant introduced in Europe in 1977. It is a phenylpiperazine-substituted triazole derivative with a composition that classifies it as an analog of tradozone and presents a similar pharmacological profi...

    Categories: Serotonin Receptor Antagonists, Serotonin 5-HT2 Receptor Antagonists
  7. Drug

    Dorzolamide

    go.drugbank.com/drugs/DB00869
    ApprovedInvestigational

    Dorzolamide is a non-bacteriostatic sulfonamide derivative and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and ocular hypertension. It works by blocking an...

    Mixtures: DORZOCOMP VISI 20+5MG/ML, DORZOCOMP VISI 20+5MG/ML
  8. Drug

    DL-alpha-Tocopherol

    go.drugbank.com/drugs/DB14476
    ApprovedInvestigational

    Mixtures: Eden With Vitamins A, C, and E
  9. Drug

    Fidaxomicin

    go.drugbank.com/drugs/DB08874
    ApprovedInvestigational

    [A190516] The FDA initially approved fidaxomicin in May 2011 for the treatment of _C. difficile_-associated diarrhea in adult patients over the age of 18. … Fidaxomicin is a novel macrolide antibiotic used in the treatment of diarrhea caused by _Clostridioides_ (formerly _Clostridium_) _difficile_ in adult and pediatric patients over the age of 6 months.

  10. Drug

    Aluminum zirconium pentachlorohydrate

    go.drugbank.com/drugs/DB11147
    Approved

    Its main mechanism of action is through blocking the pores via formation of polymer complex and preventing sweat from leaving the body.