DL-alpha-Tocopherol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Citranatal Harmony
Generic Name
DL-alpha-Tocopherol
DrugBank Accession Number
DB14476
Background

Not Available

Type
Small Molecule
Groups
Approved, Experimental, Investigational
Structure
Weight
Average: 430.717
Monoisotopic: 430.38108085
Chemical Formula
C29H50O2
Synonyms
  • (+)-alpha-tocopherol
  • (±)-α-tocopherol
  • all-rac-alpha-tocopherol
  • DL-5,7,8-trimethyltocol
  • DL-alpha tocopherol
  • DL-α-tocopherol
  • Vitamin E DL-alpha
External IDs
  • E-307C
  • Ins no.307C
  • INS-307C

Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination to preventVitamin deficiency•••••••••••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
OrlistatOrlistat can cause a decrease in the absorption of DL-alpha-Tocopherol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Food Interactions
No interactions found.

Products

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Advanced E With Non-medicinal Grape Seed ExtractCapsule400 unit / capOralVita Health Products Inc2000-03-012002-07-30Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Antiphlamine Coin PlasterDL-alpha-Tocopherol (0.308 mg/0.2832g) + Diphenhydramine (0.246 mg/0.2832g) + Levomenthol (2.769 mg/0.2832g) + Methyl salicylate (5.541 mg/0.2832g) + Nonivamide (0.046 mg/0.2832g) + Peppermint oil (0.693 mg/0.2832g) + Synthetic camphor (1.108 mg/0.2832g)PatchTopicalHanul Trading Co., Ltd.2016-10-10Not applicableUS flag
Arepanrix H5n1DL-alpha-Tocopherol (11.86 mg / 0.5 mL) + Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated) (3.75 mcg / 0.5 mL) + Polysorbate 80 (4.86 mg / 0.5 mL) + Squalene (10.69 mg / 0.5 mL)EmulsionIntramuscularID Biomedical Corporation of QuebecNot applicableNot applicableCanada flag
CERNEVIT FOR INJECTIONDL-alpha-Tocopherol (11.2 iu/vial) + Ascorbic acid (125 mg) + Biotin (0.069 mg) + Cholecalciferol (220 iu) + Cocarboxylase tetrahydrate (3.51 mg) + Cyanocobalamin (0.006 mg) + Dexpanthenol (17.25 mg/vial) + Folic acid (0.414 mg/vial) + Nicotinamide (46 mg/vial) + Pyridoxine hydrochloride (4.53 mg/vial) + Riboflavin (4.14 mg/vial) + Vitamin A palmitate (3500 iu/vial)Injection, powder, for solutionIntravenousBAXTER HEALTHCARE (ASIA) PTE LTD2002-05-06Not applicableSingapore flag
Eden With Vitamins A, C, and EDL-alpha-Tocopherol (1.8 unit / tab) + Ascorbic acid (10 mg / tab) + Beta carotene (0.8 mg / tab)TabletOralWarner Lambert Canada Inc.Not applicableNot applicableCanada flag
P.N. Vitamin-mineral DrinkDL-alpha-Tocopherol (30 unit / 30 mL) + Ascorbic acid (60 mg / 30 mL) + Beta carotene (5550 unit / 30 mL) + Biotin (300 mcg / 30 mL) + Cyanocobalamin (6 mcg / 30 mL) + Folic acid (0.4 mg / 30 mL) + Iron (6 mg / 30 mL) + Nicotinamide (20 mg / 30 mL) + Calcium pantothenate (10 mg / 30 mL) + Pyridoxine hydrochloride (2 mg / 30 mL) + Riboflavin (1.7 mg / 30 mL) + Thiamine (1.5 mg / 30 mL) + Vitamin A palmitate (3150 unit / 30 mL) + Vitamin D (400 unit / 30 mL)LiquidOralChanges InternationalNot applicableNot applicableCanada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Antiphlamine Coin PlasterDL-alpha-Tocopherol (0.308 mg/0.2832g) + Diphenhydramine (0.246 mg/0.2832g) + Levomenthol (2.769 mg/0.2832g) + Methyl salicylate (5.541 mg/0.2832g) + Nonivamide (0.046 mg/0.2832g) + Peppermint oil (0.693 mg/0.2832g) + Synthetic camphor (1.108 mg/0.2832g)PatchTopicalHanul Trading Co., Ltd.2016-10-10Not applicableUS flag
CitraNatal HarmonyDL-alpha-Tocopherol (30 [iU]/1) + Calcium citrate tetrahydrate (100 mg/1) + Cholecalciferol (400 [iU]/1) + Doconexent (250 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Pyridoxine hydrochloride (25 mg/1)Capsule, gelatin coatedOralMission Pharmacal2010-04-27Not applicableUS flag
CitraNatal HarmonyDL-alpha-Tocopherol (30 [iU]/1) + Calcium citrate tetrahydrate (100 mg/1) + Cholecalciferol (400 [iU]/1) + Doconexent (250 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (28 mg/1) + Pyridoxine hydrochloride (25 mg/1)Capsule, gelatin coatedOralMission Pharmacal2011-04-18Not applicableUS flag
CitraNatal HarmonyDL-alpha-Tocopherol (30 [iU]/1) + Calcium citrate tetrahydrate (104 mg/1) + Cholecalciferol (400 [iU]/1) + Doconexent (260 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Iron (30 mg/1) + Pyridoxine hydrochloride (25 mg/1)Capsule, gelatin coatedOralMission Pharmacal2012-01-15Not applicableUS flag
Escavite DDL-alpha-Tocopherol (30 [iU]/1) + Ascorbic acid (100 mg/1) + Beta carotene (2500 [iU]/1) + Biotin (45 ug/1) + Cholecalciferol (600 [iU]/1) + Cupric oxide (2 mg/1) + Ferrous cysteine glycinate (6 mg/1) + Folic acid (400 ug/1) + Hydroxocobalamin (6 ug/1) + Magnesium oxide (60 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (2 mg/1) + Riboflavin (1.7 mg/1) + Sodium fluoride (0.25 mg/1) + Thiamine hydrochloride (1.5 mg/1) + Zinc oxide (15 mg/1)Tablet, chewableOralGM Pharmaceuticals, INC2014-03-032018-11-01US flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as tocopherols. These are vitamin E derivatives containing a saturated trimethyltridecyl chain attached to the carbon C6 atom of a benzopyran ring system. The differ from tocotrienols that contain an unsaturated trimethyltrideca-3,7,11-trien-1-yl chain.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Prenol lipids
Sub Class
Quinone and hydroquinone lipids
Direct Parent
Tocopherols
Alternative Parents
Diterpenoids / 1-benzopyrans / Alkyl aryl ethers / Benzenoids / Oxacyclic compounds / Hydrocarbon derivatives
Substituents
1-benzopyran / Alkyl aryl ether / Aromatic heteropolycyclic compound / Benzenoid / Benzopyran / Chromane / Diterpenoid / Ether / Hydrocarbon derivative / Organic oxygen compound
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
vitamin E (ALPHA-TOCOPHEROL)
Affected organisms
Not Available

Chemical Identifiers

UNII
7QWA1RIO01
CAS number
10191-41-0
InChI Key
GVJHHUAWPYXKBD-UHFFFAOYSA-N
InChI
InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
IUPAC Name
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol
SMILES
CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(O)=C(C)C(C)=C2O1

References

General References
Not Available
ChemSpider
2032
BindingDB
50436220
RxNav
220893
ChEBI
93909
ChEMBL
CHEMBL49563

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentAlzheimer's Disease (AD)1
2WithdrawnTreatmentHyperinsulinism-Hyperammonemia Syndrome1
2, 3CompletedPreventionAtherosclerosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CapsuleOral400 unit / cap
PatchTopical
EmulsionIntramuscular
Injection, powder, for solutionIntravenous
Capsule, gelatin coatedOral
TabletOral
CapsuleOral
Injection, emulsionIntravenous
LiquidOral
Tablet, coatedOral
Tablet, chewableOral
PowderOral
Injection, solution, concentrateIntravenous
EmulsionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility7.04e-06 mg/mLALOGPS
logP8.84ALOGPS
logP10.51Chemaxon
logS-7.8ALOGPS
pKa (Strongest Acidic)10.8Chemaxon
pKa (Strongest Basic)-4.9Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area29.46 Å2Chemaxon
Rotatable Bond Count12Chemaxon
Refractivity135.37 m3·mol-1Chemaxon
Polarizability56.18 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability0Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-8293800000-a57e127653bbb81ba41a
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-0000900000-bd7ecb9ebd699f4b6394
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-01t9-0902400000-ada5eecb1a4dff613657
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0595-9213000000-cbf40775378f662c2900
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0292-0795300000-0cf018c231918c65a1ca
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-053r-9230000000-cb63548d7ebd18fd48a8
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-216.56212
predicted
DeepCCS 1.0 (2019)
[M+H]+220.22978
predicted
DeepCCS 1.0 (2019)
[M+Na]+229.04488
predicted
DeepCCS 1.0 (2019)

Drug created at July 06, 2018 18:47 / Updated at February 24, 2024 22:00