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Simeprevir
go.drugbank.com/drugs/DB06290ApprovedWithdrawnInhibiting HCV NS3/4A protease in a potent and highly specific manner, simeprevir is a direct-acting antiviral agent against the hepatitis C virus. … Like all NS3/4A inhibitors, simeprevir is a serine protease inhibitor in similarity to [DB08873] and [DB05521] but is classified as a second generation protease inhibitor.
Categories: NS3/4A Protease Inhibitors, HCV NS3/4A Protease InhibitorsTaurine
go.drugbank.com/drugs/DB01956ApprovedInvestigationalNutraceuticalTaurine, whose chemical name is 2-aminoethanesulfonic acid, is one of the most abundant amino acids in several organs. It plays important role in essential biological processes. … [A31396] This conditional amino acid can be either be manufactured by the body or obtained in the diet mainly by the consumption of fish and meat.
Mixtures: AA-Ven, SMOFKABIVEN EFLutropin alfa
go.drugbank.com/drugs/DB00044ApprovedInvestigationalIts pharmacological action mimics the biological activity of endogenous LH; an acute rise of LH, or LH surge, in females triggers ovulation and the development of the corpous luteum. … In males, LH stimulates Leydig cell to produce testosterone.
Synonyms: Recombinant LHPolyethylene glycol 400
go.drugbank.com/drugs/DB11077ApprovedInvestigationalIn addition, PEG is available as a bowel preparation for colonoscopy procedures and as a laxative [L1788]. … It is very hydrophilic, which renders it a useful ingredient in drug formulations to augment the solubility and bioavailability of weakly water-soluble drugs.
Mixtures: SYSTANE HA SP SOLUCIÓN OFTÁLMICA, SYSTANE ® HA GOTAS OFTALMICAS LUBRICANTESCategories: Compounds used in a research, industrial, or household settingDaclizumab
go.drugbank.com/drugs/DB00111ApprovedInvestigationalWithdrawnOn 22 April 2008, Roche Registration Limited chose to voluntarily withdraw the marketing authorization for their product Zenapax (daclizumab), as indicated for the prophylaxis of acute organ rejection … Despite being approved for use, Zinbryta (daclizumab)'s complex pre-existing safety profile consisting of its restricted availability through a Risk Evaluation and Mitigation Strategy program [L1738] and
Products: Zinbryta PenGlutamic acid
go.drugbank.com/drugs/DB00142ApprovedInvestigationalNutraceuticalA peptide that is a homopolymer of glutamic acid.
Mixtures: Olimel 7.6% E, Olimel 4.4% ESynonyms: L-Glutamate, L-Glutamic acidLevomefolic acid
go.drugbank.com/drugs/DB11256ApprovedLevomefolic acid (INN) is the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma … Levomefolate is approved as a food additive and is designated a GRAS (generally regarded as safe) compound [L773].
Mixtures: Enl, Obstetrix ECCategories: Vitamin B ComplexVoxilaprevir
go.drugbank.com/drugs/DB12026ApprovedInvestigationalNotably, Vosevi is approved for use in patients with genotypes 1-6 who have been previously treated with an NS5A inhibitor, or patients with genotypes 1a or 3 infection and have previously been treated … Voxilaprevir has been available since July 2017 in a fixed dose combination product with [sofosbuvir] and [velpatasvir] as the commercially available product Vosevi.
Categories: NS3/4A Protease Inhibitors, HCV NS3/4A Protease InhibitorsChromium picolinate
go.drugbank.com/drugs/DB11255ApprovedChromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. … Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid.
Mixtures: ActiveLife ALA Plus CapsuleCategories: Compounds used in a research, industrial, or household settingDaclatasvir
go.drugbank.com/drugs/DB09102ApprovedInvestigationalWithdrawnThe most common critical NS5A amino acid substitutions that led to reduced susceptibility to daclatasvir therapy occured at position Q30 (Q30H/K/R) and M28 in genotype 1a patients and Y93H in genotype … Binding to the N-terminus of the D1 domain of NS5A prevents its interaction with host cell proteins and membranes required for virion replication complex assembly.
Categories: HCV Replication Complex Inhibitors