This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Chromium picolinate
DrugBank Accession Number
DB11255
Background

Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are shown to regulate insulin by promoting glucose utilization and increasing the sensitivity of the insulin receptor 1.

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 418.3005
Monoisotopic: 418.013122035
Chemical Formula
C18H12CrN3O6
Synonyms
  • Chromium(III) picolinate

Pharmacology

Indication

Not Available

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Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
  • Administer vitamin supplements. Foods or supplements containing niacin (Vitamin B3) may improve the absorption of chromium.
  • Take with foods containing vitamin C. Foods rich in vitamin C increase the absorption of chromium.

Products

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Active Moieties
NameKindUNIICASInChI Key
Chromiumunknown0R0008Q3JB7440-47-3VYZAMTAEIAYCRO-UHFFFAOYSA-N
Chromic cationionicX1N4508KF116065-83-1BFGKITSFLPAWGI-UHFFFAOYSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
MENOPACE KAPSUL, 30 ADETChromium picolinate (50 mcg) + Aminobenzoic acid (30 mg) + Ascorbic acid (45 mg) + Biotin (30 mcg) + Boron (2 mg) + Copper (1 mg) + Cyanocobalamin (9 mcg) + Folic acid (400 mcg) + Iodine (225 mcg) + Iron (12 mg) + Magnesium (100 mg) + Manganese (2 mg) + Niacin (20 mg) + Pantothenic acid (30 mg) + Pyridoxine (40 mg) + Riboflavin (5 mg) + Selenium (100 mcg) + Thiamine (10 mg) + Vitamin A (750 mcg) + Vitamin D (2.5 mcg) + Vitamin E (30 mg) + Zinc (15 mg)CapsuleOralNOBEL İLAÇ SAN. VE TİC. A.Ş.2020-08-142020-05-28Turkey flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
DivistaChromium picolinate (1000 ug/1) + Biotin (2 mg/1) + Cyanocobalamin (15 ug/1) + Folic acid (1 mg/1) + Omega-3-acid ethyl esters (300 mg/1) + Pyridoxine (25 mg/1)CapsuleOralUs Pharmaceutical Corporation2010-07-102011-09-30US flag
Medi-10Chromium picolinate (1 mg/1) + Acetylcysteine (200 mg/1) + Cholecalciferol (1000 [iU]/1) + Levomefolate calcium (2.5 mg/1) + Lipoic acid (200 mg/1) + Mecobalamin (2.5 mg/1) + Nicotinamide (10 mg/1) + Pyridoxal phosphate (20 mg/1) + Resveratrol (83 mg/1) + Ubidecarenone (16 mg/1)CapsuleOralMedicap Laboratories Inc.2015-05-012016-01-12US flag
RE FAC-xChromium picolinate (200 ug/1) + Ascorbic acid (200 mg/1) + Biotin (200 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (2.5 mg/1) + Cyanocobalamin (2500 ug/1) + Folic acid (2800 ug/1) + Lutein (500 ug/1) + Lycopene (500 ug/1) + Magnesium (100 mg/1) + Manganese sulfate (2.5 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Selenomethionine (100 ug/1) + Thiamine mononitrate (20 mg/1) + Vitamin A (5000 [iU]/1) + Vitamin E (100 [iU]/1) + Zinc (15 mg/1)TabletOralRiver’s Edge Pharmaceuticals, LLC2007-07-012011-01-13US flag
Vita-Rx Diabetic VitaminChromium picolinate (0.465 mg/1) + Ascorbic acid (120 mg/1) + Biotin (2.5 mg/1) + Cholecalciferol (0.0625 mg/1) + Folic acid (0.8 mg/1) + Lipoic acid (150 mg/1) + Mecobalamin (0.0025 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxal phosphate (12.5 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) + Ubidecarenone (50 mg/1) + alpha-Tocopherol acetate (10 mg/1)Capsule, gelatin coatedOralPure Source, Llc2015-08-11Not applicableUS flag
Vita-Rx Diabetic VitaminChromium picolinate (0.465 mg/1) + Ascorbic acid (120 mg/1) + Biotin (2.5 mg/1) + Cholecalciferol (0.0625 mg/1) + Folic acid (0.8 mg/1) + Lipoic acid (150 mg/1) + Mecobalamin (0.0025 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxal phosphate (12.5 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) + Ubidecarenone (50 mg/1) + alpha-Tocopherol acetate (10 mg/1)Capsule, gelatin coatedOralMas Management Group Inc.2015-08-11Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as pyridinecarboxylic acids. These are compounds containing a pyridine ring bearing a carboxylic acid group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Pyridines and derivatives
Sub Class
Pyridinecarboxylic acids and derivatives
Direct Parent
Pyridinecarboxylic acids
Alternative Parents
Heteroaromatic compounds / Carboxylic acid salts / Monocarboxylic acids and derivatives / Carboxylic acids / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organic zwitterions / Organic oxides
show 2 more
Substituents
Aromatic heteromonocyclic compound / Azacycle / Carboxylic acid / Carboxylic acid derivative / Carboxylic acid salt / Heteroaromatic compound / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Organic chromium salt / Organic nitrogen compound
show 9 more
Molecular Framework
Not Available
External Descriptors
chromium coordination entity (CHEBI:50369)
Affected organisms
Not Available

Chemical Identifiers

UNII
S71T8B8Z6P
CAS number
14639-25-9
InChI Key
CBDQOLKNTOMMTL-UHFFFAOYSA-K
InChI
InChI=1S/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3
IUPAC Name
chromium(3+) tris(pyridine-2-carboxylate)
SMILES
[Cr+3].[O-]C(=O)C1=NC=CC=C1.[O-]C(=O)C1=NC=CC=C1.[O-]C(=O)C1=NC=CC=C1

References

General References
  1. Broadhurst CL, Domenico P: Clinical studies on chromium picolinate supplementation in diabetes mellitus--a review. Diabetes Technol Ther. 2006 Dec;8(6):677-87. [Article]
PubChem Compound
625469
PubChem Substance
347827953
ChemSpider
133913
RxNav
59308
ChEBI
50369
Wikipedia
Chromium(III)_picolinate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentType 2 Diabetes Mellitus1
1TerminatedTreatmentType 2 Diabetes Mellitus1
Not AvailableCompletedPreventionAtypical Depression / Obesity1
Not AvailableCompletedTreatmentImpaired Glucose Tolerance / Metabolic Diseases / Obesity / Resistance, Insulin / Syndrome, Metabolic1
Not AvailableCompletedTreatmentType 2 Diabetes Mellitus2

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet, coatedOral
CapsuleOral
TabletOral
Tablet, film coatedOral
Capsule, gelatin coatedOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0312 mg/mLALOGPS
logP2.9ALOGPS
logP-0.65ChemAxon
logS-4.1ALOGPS
pKa (Strongest Acidic)1ChemAxon
pKa (Strongest Basic)5.52ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area53.02 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity41.62 m3·mol-1ChemAxon
Polarizability10.94 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53