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Eteplirsen
go.drugbank.com/drugs/DB06014ApprovedInvestigationalEteplirsen was first approved by the FDA in September 2016 for the treatment of Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gene, which codes for dystrophin, that … Eteplirsen is a synthetic antisense oligonucleotide and a phosphorodiamidate morpholino oligomer.
Synonyms: (P-deoxy-P-(dimethylamino)](2',3'-dideoxy-2',3'-imino-2',3'-seco)(2'a→5')(C-m5U-C-C-A-A-C-A-m5U-C-A-A-G-G-A-A-G-A-m5U-G-G-C-A-m5U-m5U-m5U-C-m5U-A-G),5'-(P-(4-((2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)carbonylCategories: Compounds used in a research, industrial, or household settingGallium citrate Ga-67
go.drugbank.com/drugs/DB06784ApprovedGallium citrate Ga 67 is the citrate salt of the radioisotope gallium Ga 67. … Although the mechanism is unknown, gallium Ga 67 concentrates in lysosomes and is bound to a soluble intracellular protein in certain viable primary and metastatic tumors and focal sites of inflammation
Synonyms: Gallium (67 Ga) citrate, Gallium citrate Ga 67Products: GA - 67 MM-1, Gallium Citrate Ga-67Alpelisib
go.drugbank.com/drugs/DB12015ApprovedInvestigationalTo initiate alpelisib therapy, it is required that the presence of a PIK3CA mutation in the tissue and/or liquid biopsy sample collection should be confirmed via FDA-approved diagnostic tests. … negative, PIK3CA-mutated, advanced or metastatic breast cancer in combination with [fulvestrant] for postmenopausal women and male patients.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexZalcitabine
go.drugbank.com/drugs/DB00943ApprovedWithdrawnA dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. … This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseTreosulfan
go.drugbank.com/drugs/DB11678ApprovedInvestigationalTreosulfan is a prodrug alternative to [busulfan] for myeloablative conditioning prior to hematopoietic stem cell transplantation. … [L52245] It was approved by the EMA in June 2019[L16965] and by the FDA in January 2025 for use in combination with [fludarabine].[L52575]
Synonyms: L-threitol-1,4-dimethanesulfonateProducts: Treosulfan for InjectionAmylmetacresol
go.drugbank.com/drugs/DB13908ApprovedAmylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections [L2570], [L2571]. … The acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in the primary care setting.
Glutamic acid
go.drugbank.com/drugs/DB00142ApprovedInvestigationalNutraceuticalA peptide that is a homopolymer of glutamic acid.
Mixtures: Primene 10% pur - Infusionslösung, GLAMIN SOLUTION FOR INFUSIONSynonyms: L-Glutamate, L-Glutamic acidEthionamide
go.drugbank.com/drugs/DB00609ApprovedInvestigationalWithdrawnA second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Categories: Antiinfectives for Systemic Use, Drugs for Treatment of TuberculosisSodium citrate
go.drugbank.com/drugs/DB09154ApprovedInvestigationalIt is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. … It has been indicated for the treatment of metabolic acidosis.
Mixtures: REGIOCIT SOLUTION FOR HAEMOFILTRATION, REGIOCIT SOLUTION FOR HAEMOFILTRATIONCategories: Compounds used in a research, industrial, or household settingCarbopol 974P
go.drugbank.com/drugs/DB05384ApprovedWithdrawnThe compound, known as BufferGel, was in advanced clinical trials for its ability to prevent pregnancy, but was discontinued. … Carbopol 974P is a highly carboxylated polymer composed of lightly cross-linked polyacrylic acid with a broad-spectrum mechanism based on acidification of pathogens.
Categories: Compounds used in a research, industrial, or household setting