Search

Displaying results 1081 - 1090 of 10000 in total
  1. Target

    Cocaine esterase

    go.drugbank.com/bio_entities/BE0004712
    EnzymeHumans

    Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (P...

    Polypeptides: Cocaine esterase
  2. Target

    Esterase, putative

    go.drugbank.com/bio_entities/BE0009247
    TargetPlasmodium falciparum (isolate 3D7)

    Polypeptides: Esterase, putative
  3. Drug

    Morphine

    go.drugbank.com/drugs/DB00295
    ApprovedInvestigational

    Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805.[A176035] It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. … [A176050] Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [fentanyl], [methadone], [hydrocodone], [hydromorphone], [meperidine

    Synonyms: (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol, (7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diolCategories: Cytochrome P-450 Substrates, P-glycoprotein substrates
  4. Drug

    Evening primrose oil

    go.drugbank.com/drugs/DB11358
    ApprovedNutraceutical

    [A33131] Evening primrose oil has been filled for the FDA by Humanetics Corporation on April 2000 to be a new dietary ingredient but its current status is "Inadequate basis for expectation of safety". … Evening primrose oil comes from the extraction from _Oenothera biennis_ seeds and it is commonly used as an alternative source for omega-6 essential fatty acids.

    Mixtures: PRIM E CAPSULE, Evening Primrose Oil With Vitamin ECategories: Fatty Acids, Omega-6, Cytochrome P-450 CYP2C19 Inhibitors
  5. Drug

    Terfenadine

    go.drugbank.com/drugs/DB00342
    ApprovedWithdrawn

    In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: (RS)-1-(4-tert-butylphenyl)-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}-butan-1-ol
  6. Drug

    Vancomycin

    go.drugbank.com/drugs/DB00512
    ApprovedInvestigational

    It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. … Such an oral liquid formulation is expected to make _Clostridium difficile_ associated diarrhea therapy more accessible in comparison to previously available specialty compounding products [LP1196].

    Categories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic IndexProducts: INJOVAN®500 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE, INJOVAN®1000 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE
  7. Indication

    Bacterial infection due to streptococcus, group A

    go.drugbank.com/conditions/DBCOND0025102
    Drugs: Clavulanic acid
    Synonyms: Bacterial infection due to streptococcus, group A
  8. Indication

    Bleeding caused by Hemophilia A Without Inhibitor

    go.drugbank.com/conditions/DBCOND0170627
    Drugs: Fitusiran · Marstacimab
    Synonyms: Bleeding caused by Hemophilia A Without Inhibitor
  9. Indication

    Proteinuria caused by Primary Immunoglobulin A Nephropathy

    go.drugbank.com/conditions/DBCOND0168683
    Drugs: Sibeprenlimab
    Synonyms: Proteinuria caused by Primary Immunoglobulin A Nephropathy
  10. Pathway

    Estrone sulfate Predicted Metabolism Pathway

    smpdb.ca/view/SMP0174577
    Metabolic

    Metabolites of Estrone sulfate are predicted with biotransformer.

    Drugs: Mesoheme · Estrone sulfate