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Zonisamide
go.drugbank.com/drugs/DB00909ApprovedInvestigational[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors … This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.
Categories: combinations of sulfonamides, Compounds used in a research, industrial, or household settingSynonyms: Benzo[d]isoxazol-3-yl-methanesulfonamideLonapegsomatropin
go.drugbank.com/drugs/DB16220ApprovedInvestigational[L36380,L10971] Lonapegsomatropin was granted FDA approval on 25 August 2021.[L36380] It was later approved by the European Commission on 13 January 2022.[L39900] … Lonapegsomatropin, also known as TransCon hGH or ACP 001, is a methoxypegylated prodrug of human growth hormone ([somatropin]) indicated for the treatment of children 1 year and older, weighing at least
Mechlorethamine
go.drugbank.com/drugs/DB00888ApprovedInvestigationalThe FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL … Each tube of Valchlor contains 0.016% of mechlorethamine which is equivalent to 0.02% mechlorethamine HCl.
Categories: Weapons of Mass Destruction, Compounds used in a research, industrial, or household settingSynonyms: 2,2'-dichloro-N-methyldiethylamine, N-methyl-bis(2-chloroethyl)amineCalcifediol
go.drugbank.com/drugs/DB00146ApprovedInvestigationalNutraceuticalThe major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. … It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
Categories: Vitamin D and AnaloguesSynonyms: 25-Hydroxyvitamin D3Carindacillin
go.drugbank.com/drugs/DB09319ApprovedWithdrawnCarindacillin or Carbenicillin isdanyl was an oral penicillin prodrug of [carbenicillin] marketed by Pfizer as Geocillin. It is no longer marketed in the United States.
Categories: combinations of penicillinsPepsin
go.drugbank.com/drugs/DB13198ApprovedWithdrawnStudies on gastric digestion from 1820-1840 led to the discovery of pepsin as the substance which, in the presence of stomach acid, causes nutrients including meat or coagulated egg whites to dissolve. … Stimulation of the pancreas and therefore enzymatic digestion of food is a tightly controlled and is a hormonally mediated process.
Mixtures: Glutamic Acid Hydrochloride Nu LifeCetyl alcohol
go.drugbank.com/drugs/DB09494ApprovedDue to its water-binding property, cetyl alcohol is commonly used as an emollient that prevents drying and chapping of the skin [A32209]. … of total alcohols and not less than 94 percent of straight chain alcohols [L1824].
Synonyms: hexadecan-1-olDorzolamide
go.drugbank.com/drugs/DB00869ApprovedInvestigational[A1303] Unlike oral CA inhibitors, dorzolamide has negligible effects of acid-base or electrolyte disturbances and other systemic adverse effects. … [A1304] First marketed in 1995,[A190624] dorzolamide is available in ophthalmic solutions as monotherapy marketed as Trusopt [L11377] or in combination with [timolol] as Cosopt PF.[L11380]
Mixtures: NEFRIDAXEM B+D, KRYTANTEK OFTENO® LIBRE DE CONSERVADORESCategories: combinations of sulfonamidesTyrosine
go.drugbank.com/drugs/DB00135ApprovedInvestigationalNutraceuticalTyrosine is a non-essential amino acid. In animals it is synthesized from [phenylalanine]. It is also the precursor of [epinephrine], thyroid hormones, and melanin.
Mixtures: Appformin-D, Appbutamone-DMoxetumomab pasudotox
go.drugbank.com/drugs/DB12688ApprovedInvestigationalThe predecessor of Moxetumab pasudotox (MxP), named BL22, was first created based on the antibody RFB4 which specifically binds to CD22. … [A38864] It was developed by Astra Zeneca and FDA approved on September 13, 2018, after being granted the status of Fast Track, Priority Review and Orphan Drug designations.[L4568]
Categories: CD22 (Clusters of Differentiation 22) inhibitors