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Acyl-coenzyme A thioesterase 13
go.drugbank.com/bio_entities/BE0004376TargetHumansMay play a role in controlling adaptive thermogenesis (By similarity) … Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity) (PubMed:16934754, PubMed:19170545).
Polypeptides: Acyl-coenzyme A thioesterase 13Ras-related protein Ral-A
go.drugbank.com/bio_entities/BE0004562TargetHumansMultifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. … Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108).
Polypeptides: Ras-related protein Ral-ASerum amyloid A-1 protein
go.drugbank.com/bio_entities/BE0004795TargetHumansMajor acute phase protein
Polypeptides: Serum amyloid A-1 proteinEphrin type-A receptor 3
go.drugbank.com/bio_entities/BE0009437TargetHumansAlso activated by EFNA1, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development (PubMed:12794130). Involved in the retinotectal mapping of neurons. … Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5 (By similarity).
Polypeptides: Ephrin type-A receptor 3Ephrin type-A receptor 6
go.drugbank.com/bio_entities/BE0009439TargetHumansReceptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
Polypeptides: Ephrin type-A receptor 6ATP-dependent RNA helicase A
go.drugbank.com/bio_entities/BE0014303TargetHumansPlays a role in mRNA translation (PubMed:28355180). … Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing
Polypeptides: ATP-dependent RNA helicase ASynonyms: RNA helicase AAztreonam
go.drugbank.com/drugs/DB00355ApprovedInvestigationalIt is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms. … A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum.
Synonyms: (Z,)-2-((((2-Amino-4-thiazolyl)(((2S,3S,)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid, 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl) -2- {[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino} -2- oxoethylidene]amino}oxy)-2-methylpropanoic acidCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingAntithrombin III human
go.drugbank.com/drugs/DB11598ApprovedInvestigationalA plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Synonyms: Antithrombin III (human) concentrate IV, AT-IIIProducts: KYBERNIN P 500 IU IV ENJEKSİYONLUK İNFÜZYONLUK LİYOFİLİZE TOZ VE ÇÖZÜCÜ, AT III KEDRIONAcetyl-coenzyme A synthetase, cytoplasmic
go.drugbank.com/bio_entities/BE0000350TargetEnzymeHumansGlucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter … Can also utilize propionate with a much lower affinity (PubMed:38369012). Catalyzes the conversion of lactate into lactoyl-CoA (PubMed:39561764).
Polypeptides: Acetyl-coenzyme A synthetase, cytoplasmic