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Lumateperone Dopamine Action Action Pathway
smpdb.ca/view/SMP0126694Drug actionLumateperone, also known as ITI-007, is approved for the treatment of schizophrenia in adults. It is also approved for the treatment of depressive episodes associated with bipolar disorder (i.e. bipolar depression) in adults, as monother...
Enzymes: Sodium-dependent dopamine transporterLumateperone Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126695Drug actionLumateperone, also known as ITI-007, is approved for the treatment of schizophrenia in adults. It is also approved for the treatment of depressive episodes associated with bipolar disorder (i.e. bipolar depression) in adults, as monother...
Enzymes: Sodium-dependent serotonin transporterAgomelatine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126726Drug actionAgomelatine is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors and promotes dopamine and norepinephrine release. Agomelatine is indica...
Enzymes: Sodium-dependent serotonin transporterAsenapine Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126737Drug actionAsenapine is a serotonin, dopamine, noradrenaline, and histamine antagonist in which asenapine possess more potent activity with serotonin receptors than dopamine. Asenapine is an atypical antipsychotic multireceptor neuroleptic drug whi...
Enzymes: Sodium-dependent serotonin transporterTropisetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126780Drug actionTropisetron is an indole derivative. Tropisetron competitively binds to and blocks the action of serotonin at 5HT3 receptors peripherally on vagus nerve terminals located in the gastrointestinal (GI) tract as well as centrally in the che...
Enzymes: Sodium-dependent serotonin transporterPalonosetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126781Drug actionPalonosetron is a selective serotonin 5-HT3 receptor antagonist. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tr...
Enzymes: Sodium-dependent serotonin transporterIloperidone Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126784Drug actionIloperidone shows high affinity and maximal receptor occupancy for dopamine D2 receptors in the caudate nucleus and putamen of the brains of schizophrenic patients. The improvement in cognition is attributed to iloperidone's high affinit...
Enzymes: Sodium-dependent serotonin transporterMetoclopramide - Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126993Drug actionMetoclopramide is a dopamine receptor antagonist and has been approved by the FDA to treat nausea and vomiting in patients with gastroesophageal reflux disease or diabetic gastroparesis by increasing gastric motility.. Metoclopramide wor...
Enzymes: Sodium-dependent dopamine transporterLurasidone Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126527Drug actionLurasidone is is a benzothiazol derivative and an atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Lurasidone is an atypical antipsychotic that is a D2 and 5-HT2A (mixed serot...
Enzymes: Sodium-dependent serotonin transporterPerphenazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126530Drug actionPerphenazine is a piperazinyl phenothiazine first generation antipsychotic that acts on the central nervous system, and has a greater behavioral potency than other phenothiazine derivatives whose side chains do not contain a piperazine m...
Enzymes: Sodium-dependent dopamine transporter