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Displaying results 101 - 110 of 157601 in total
  1. Drug

    Butabarbital

    go.drugbank.com/drugs/DB00237
    ApprovedIllicitWithdrawn

    [A19735] Its short duration of action gives butabarbital a high abuse potential, comparable to [secobarbital].[A201977,A201980] Butabarbital was granted FDA approval on 5 June 1939.[L13613] … Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione, 5-ethyl-5-(1-methylpropyl)barbituric acid
  2. Drug

    3-carboxamido-1,3,5(10)-estratrien-17(R)-spiro-2'(5',5'-dimethyl-6'oxo)tetrahydropyran

    go.drugbank.com/drugs/DB07700
    Experimental

  3. Drug

    Pioglitazone

    go.drugbank.com/drugs/DB01132
    ApprovedInvestigational

    [L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in vivo_ with little consequence … [A19757] PPARs are ligand-activated transcription factors that are involved in the expression of more than 100 genes and affect numerous metabolic processes, most notably lipid and glucose homeostasis.

    Mixtures: DROPIA-MET 15/850 MG FILM TABLET, 180 ADET, PIO-MET 15/500 MG FILM TABLET, 30 ADETCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 Substrates
  4. Drug

    Albendazole

    go.drugbank.com/drugs/DB00518
    ApprovedInvestigationalVet approved

    A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)

    Synonyms: (5-(propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester, O-methyl N-(5-(propylthio)-2-benzimidazolyl)carbamateInternational brands: Ben-A
  5. Drug

    Adenosine phosphate

    go.drugbank.com/drugs/DB00131
    ApprovedInvestigationalNutraceuticalWithdrawn

    Adenosine phosphate, or adenylic acid, is an adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. … Adenosine phosphate was withdrawn by the FDA since it was considered neither safe nor effective for its intended uses as a vasodilator and an anti-inflammatory.[L43937]

    Categories: Heterocyclic Compounds, 2-RingSynonyms: 5'-AMP, Adenosine-5'P
  6. Drug

    Flavin adenine dinucleotide

    go.drugbank.com/drugs/DB03147
    Approved

    A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase.

    Categories: Vitamin B Complex, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesSynonyms: Adenosine 5'-(trihydrogen pyrophosphate), 5'-5'-ester with riboflavine, Riboflavin 5'-(trihydrogen diphosphate), 5'-5'-ester with adenosine
  7. Drug

    Artemether

    go.drugbank.com/drugs/DB06697
    ApprovedInvestigational

    It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp. … </i> and may be used to treat infections caused by <i>P. falciparum</i> and unidentified <i>Plasmodium</i> species, including infections acquired in chloroquine-resistant areas.

    Synonyms: (1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane, 10-methoxy-1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecaneMixtures: ARTELERIA (ARTEMETERO 20 MG Y LUMEFANTRINA 120 MG), COARTEM ® 20/120 MG COMPRIMIDOS
  8. Drug

    Pyridoxal phosphate

    go.drugbank.com/drugs/DB00114
    ApprovedInvestigationalNutraceutical

    This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.

    Mixtures: Medi-10, S-pan-M TabCategories: Heterocyclic Compounds, 1-Ring, Vitamin B Complex
  9. Drug

    Vinorelbine

    go.drugbank.com/drugs/DB00361
    ApprovedInvestigational

    It was initially approved in the USA in 1990's for the treatment of NSCLC [L2010]. It is a third-generation vinca alkaloid. … It was found that there was 4.3-fold variation in vinorelbine clearance across the cohort, suggesting a strong influence of genetics on the clearance of this drug [L2002].

    Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesSynonyms: 5'-Noranhydrovinblastine
  10. Drug

    Sulfisoxazole

    go.drugbank.com/drugs/DB00263
    ApprovedVet approved

    A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms.

    Synonyms: 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide, 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamideCategories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme Inhibitors