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Displaying results 101 - 110 of 178 in total
  1. Target

    Serine/threonine-protein kinase Sgk1

    go.drugbank.com/bio_entities/BE0004105
    TargetHumans

    Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity

  2. Target

    Kallikrein-7

    go.drugbank.com/bio_entities/BE0004150
    TargetHumans

    Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'.

  3. Target

    Potassium voltage-gated channel subfamily A member 5

    go.drugbank.com/bio_entities/BE0004717
    TargetHumans

    May play a role in regulating the secretion of insulin in normal pancreatic islets

  4. Target

    5-hydroxytryptamine 2 receptor

    go.drugbank.com/bio_entities/BE0004881
    TargetHumans

    Plays a role in insulin sensitivity and glucose homeostasis (By similarity)

  5. Target

    activator protein 1

    go.drugbank.com/bio_entities/BE0004924
    TargetHumans

    Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity).

  6. Target

    5-hydroxytryptamine receptor 2

    go.drugbank.com/bio_entities/BE0004957
    TargetHumans

    Plays a role in insulin sensitivity and glucose homeostasis (By similarity)

  7. Target

    Protein S100-A16

    go.drugbank.com/bio_entities/BE0008707
    TargetHumans

    Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity)

  8. Target

    Nuclear receptor subfamily 1 group D member 1

    go.drugbank.com/bio_entities/BE0009347
    TargetHumans

    Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells

  9. Target

    Interferon-induced, double-stranded RNA-activated protein kinase

    go.drugbank.com/bio_entities/BE0009434
    TargetHumans

    , which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2) (PubMed:20685959). … Can act as both a positive and negative regulator of the insulin signaling pathway (ISP) (PubMed:20685959).

  10. Target

    Serine/threonine-protein kinase SIK2

    go.drugbank.com/bio_entities/BE0009538
    TargetHumans

    Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction.