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Asciminib Inhibition of BCR-ABL
smpdb.ca/view/SMP0126943Drug actionAsciminib is an inhibitor of ABL/BCR-ABL1 tyrosine kinase for the treatment of patients with Philadelphia chromosome-positive CML, including those with the T315I mutation. Asciminib is an allosteric inhibitor of the BCR-ABL1 tyrosine kin...
Drugs: AsciminibEnzymes: S-phase kinase-associated protein 2Carbazochrome
go.drugbank.com/drugs/DB09012ApprovedWithdrawnCarbazochrome is a hemostatic agent that promotes clotting, preventing blood loss from open wounds. It is an oxidation product of adrenaline which enhances the microcirculatory tone [A19747]. … It is not FDA-approved but is available as tablets or IM/SC injections in the treatment of hemorrhages in a number of countries.
Synonyms: 3-Hydroxy-1-methyl-5,6-inodlindionsemicarbazonInternational brands: Su Bo Te, Tai Si NengBamosiran
go.drugbank.com/drugs/DB12256InvestigationalBamosiran has been used in trials studying the treatment of Glaucoma, Ocular Hypertension, and Open Angle Glaucoma.
Trabodenoson
go.drugbank.com/drugs/DB13122InvestigationalTrabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary Open-Angle Glaucoma (POAG).
Categories: Adenosine A receptor agonists, Heterocyclic Compounds, 2-RingDimethylglycine Dehydrogenase Deficiency
smpdb.ca/view/SMP0000484DiseaseDimethylglycine dehydrogenase deficiency, also called DMGDH deficiency and dimethylglycinuria, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glycine metabolism caused by a defective DMGDH gene. DMGDH code...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreEnzymes: Betaine--homocysteine S-methyltransferase 1Dasatinib Inhibition of BCR-ABL Action Pathway
smpdb.ca/view/SMP0031696Drug actionDasatinib is a tyrosine kinase inhibitor used to treat chronic myelogenous leukemia (CML), a cancer characterized by increased and unregulated growth of white blood cells in the bone marrow and the accumulation of these cells in the bloo...
Drugs: DasatinibEnzymes: S-phase kinase-associated protein 2Bafetinib Inhibition of BCR-ABL Action Pathway
smpdb.ca/view/SMP0031699Drug actionBafetinib is a tyrosine kinase inhibitor used to treat chronic myelogenous leukemia (CML), a cancer characterized by increased and unregulated growth of white blood cells in the bone marrow and the accumulation of these cells in the bloo...
Drugs: BafetinibEnzymes: S-phase kinase-associated protein 2Non-Ketotic Hyperglycinemia
smpdb.ca/view/SMP0125580DiseaseNon Ketotic Hyperglycinemeia (Glycine encephalopathy; Glycine cleavage system deficiency; NKH) is caused by mutations in several genes in the mitochondrial glycine cleavage system. These include the genes encoding P protein (GLDC), T pro...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreEnzymes: Betaine--homocysteine S-methyltransferase 1LTI-03
go.drugbank.com/drugs/DB18491InvestigationalLTI-03 is a caveolin-1 Scaffolding Domain 7-Mer
Synonyms: L-threonine, l-phenylalanyl-l-threonyl-l-threonyl-l-phenylalanyl-l-threonyl-l-valyl-Imipenem
go.drugbank.com/drugs/DB01598ApprovedInvestigationalImipenem was first approved by the FDA in November 1985 as the combination product Primaxin marketed by Merck & Co.[L7628] … Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.
Mixtures: ITIXIB ® 500MG, IMIPENEM Y CILASTATINA1G.Categories: Heterocyclic Compounds, 2-Ring