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Vecuronium
go.drugbank.com/drugs/DB01339ApprovedInvestigationalA non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. … Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or
Categories: P-glycoprotein substratesProducts: BROCURIX 10 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE, BROMURO DE VECURONIO 4 MG/VIAL POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLEPralidoxime
go.drugbank.com/drugs/DB00733ApprovedInvestigationalVet approvedPralidoxime is an antidote to organophosphate pesticides and chemicals. … Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme.
Categories: Compounds used in a research, industrial, or household settingSynonyms: 2-PAMPantoprazole
go.drugbank.com/drugs/DB00213ApprovedInvestigational[A177577, A177580] Pantoprazole doses should be slowly lowered, or tapered, before discontinuing as rapid discontinuation of PPIs such as pantoprazole may cause a rebound effect and a short term increase … [FDA Label] Due to their good safety profile and as several PPIs are available over the counter without a prescription, their current use in North America is widespread.
Mixtures: OCAM® DUO.Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsHyoscyamine
go.drugbank.com/drugs/DB00424ApprovedInvestigationalHyoscyamine is a tropane alkaloid and the levo-isomer of [atropine].[A228423] It is commonly extracted from plants in the _Solanaceae_ or nightshade family. … [A228713] Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimuscarinic properties.
Mixtures: Uro-L, UR N-C Urinary AntisepticSynonyms: L-Hyoscyamine, L-Tropine tropatePramipexole
go.drugbank.com/drugs/DB00413ApprovedInvestigationalPramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). … RLS is a sleep-related disorder characterized by unpleasant sensations in the lower extremities, often accompanied by an uncontrollable urge to move the legs [A176876].
Synonyms: (S)-N 6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamineInternational brands: Sifrol ERTigecycline
go.drugbank.com/drugs/DB00560ApprovedInvestigationalTigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil. … It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus. It was granted fast-track approval by the U.S.
Synonyms: (4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamideProducts: TIGECLIN ® POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE., TIGEVITAE® 50 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLEConditions where a reduction of gastric acid secretion is required
go.drugbank.com/conditions/DBCOND0117234Drugs: PantoprazoleSynonyms: Conditions where a reduction of gastric acid secretion is requiredPleckstrin homology domain-containing family A member 4
go.drugbank.com/bio_entities/BE0001278TargetHumansBinds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides
Polypeptides: Pleckstrin homology domain-containing family A member 4Synonyms: PH domain-containing family A member 4Pleckstrin homology domain-containing family A member 1
go.drugbank.com/bio_entities/BE0003262TargetHumansBinds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane
Polypeptides: Pleckstrin homology domain-containing family A member 1Synonyms: PH domain-containing family A member 1Potassium voltage-gated channel subfamily A member 4
go.drugbank.com/bio_entities/BE0004502TargetHumansLikewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368) … Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559).
Polypeptides: Potassium voltage-gated channel subfamily A member 4