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Displaying results 1141 - 1150 of 10000 in total
  1. Pathway

    Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin

    smpdb.ca/view/SMP0000338
    Signaling

    The LHCGRs receptor activates G(s) proteins which lead to the activation of Adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (Protein Kinase A) which phosphorylates down

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  2. Drug

    Avobenzone

    go.drugbank.com/drugs/DB09495
    ApprovedInvestigational

    Avobenzone is dibenzoyl methane derivative. It is oil soluble ingredient. Avobenzone has the ability to absorb ultraviolet light over wider range of wavelengths. … In addition to limiting the skin's exposure to the sun, using sunscreen agents may help reduce long-term sun damage such as premature aging of the skin and skin cancer.

    Mixtures: Thermal S Uv SPF 20, Ponte Vedra Inn SPF 50 C/S SunscreenCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates
  3. Drug

    Sufentanil

    go.drugbank.com/drugs/DB00708
    ApprovedInvestigational

    Consideration may be made in the future for the use of the sublingual form in the US military in cases where analgesia is required immediately [L4718]. … Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to warrant the use of an opioid analgesic in certified medically supervised healthcare settings

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesSynonyms: 舒芬太尼, N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenylpropanamide
  4. Target

    Galectin-1

    go.drugbank.com/bio_entities/BE0004493
    TargetHumans

    Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylati...

    Synonyms: S-Lac lectin 1
  5. Drug

    Estriol

    go.drugbank.com/drugs/DB04573
    ApprovedInvestigationalVet approved

    It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes. … Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada.

    Mixtures: GYNOFLOR 50 MG/0.03 MG VAJİNAL TABLET, 6 ADETCategories: Sex Hormones and Modulators of the Genital System, P-glycoprotein inducers
  6. Drug

    Cyclopentamine

    go.drugbank.com/drugs/DB08999
    ApprovedWithdrawn

    Cyclopentamine is a sympathomimetic alkylamine, classified as a vasoconstrictor. Cyclopentamine was an over the counter treatment for nasal congestion in Europe and Australia. … It has been widely discontinued due to the safety, effectiveness, and availability of a similar drug, propylhexedrine.

  7. Drug

    Niacin

    go.drugbank.com/drugs/DB00627
    ApprovedInvestigationalNutraceutical

    Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.

    Mixtures: Folika-T, Se-NatalCategories: Vitamin B Complex, Cytochrome P-450 CYP2D6 Inhibitors
  8. Pathway

    Muscular Gq Protien Cascade

    smpdb.ca/view/SMP0126980
    Physiological

    G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their...

    Drugs: Calcium
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  9. Drug

    Calcium

    go.drugbank.com/drugs/DB01373
    ApprovedInvestigationalNutraceutical

    The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. … Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day.

    Mixtures: T-PA Cap, Advanced B & T FormulaCategories: ascorbic acid (vit C) and calcium
  10. Drug

    Secnidazole

    go.drugbank.com/drugs/DB12834
    ApprovedInvestigational

    [A245503] Secnidazole has been available in many other countries in Europe, Asia, South America, and Africa for decades. … [A27210] Once it enters bacteria and parasites, secnidazole is activated by bacterial or parasitic enzymes to form a radical anion, thereby damaging and killing the target pathogen.

    Mixtures: FUNEX® - S TABLETA, BATEN ® S TABLETAS RECUBIERTASCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring