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Belimumab
go.drugbank.com/drugs/DB08879ApprovedInvestigationalBelimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. … It is produced by recombinant DNA technology in a murine cell (NS0) expression system.
Categories: Decreased B Lymphocyte Activation, B Lymphocyte Stimulator-specific InhibitorProducts: BENLYSTIA SC, BENLYSTA 200 MG / 1 MLCarbazochrome
go.drugbank.com/drugs/DB09012ApprovedWithdrawnCarbazochrome is a hemostatic agent that promotes clotting, preventing blood loss from open wounds. It is an oxidation product of adrenaline which enhances the microcirculatory tone [A19747]. … It is not FDA-approved but is available as tablets or IM/SC injections in the treatment of hemorrhages in a number of countries.
Synonyms: 3-Hydroxy-1-methyl-5,6-inodlindionsemicarbazonInternational brands: Su Bo Te, Tai Si NengBamosiran
go.drugbank.com/drugs/DB12256InvestigationalBamosiran has been used in trials studying the treatment of Glaucoma, Ocular Hypertension, and Open Angle Glaucoma.
Trabodenoson
go.drugbank.com/drugs/DB13122InvestigationalTrabodenoson has been used in trials studying the treatment of Ocular Hypertension (OHT) and Primary Open-Angle Glaucoma (POAG).
Categories: Adenosine A receptor agonists, Heterocyclic Compounds, 2-RingDimethylglycine Dehydrogenase Deficiency
smpdb.ca/view/SMP0000484DiseaseDimethylglycine dehydrogenase deficiency, also called DMGDH deficiency and dimethylglycinuria, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glycine metabolism caused by a defective DMGDH gene. DMGDH code...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreEnzymes: Betaine--homocysteine S-methyltransferase 1Dasatinib Inhibition of BCR-ABL Action Pathway
smpdb.ca/view/SMP0031696Drug actionDasatinib is a tyrosine kinase inhibitor used to treat chronic myelogenous leukemia (CML), a cancer characterized by increased and unregulated growth of white blood cells in the bone marrow and the accumulation of these cells in the bloo...
Drugs: DasatinibEnzymes: S-phase kinase-associated protein 2Bafetinib Inhibition of BCR-ABL Action Pathway
smpdb.ca/view/SMP0031699Drug actionBafetinib is a tyrosine kinase inhibitor used to treat chronic myelogenous leukemia (CML), a cancer characterized by increased and unregulated growth of white blood cells in the bone marrow and the accumulation of these cells in the bloo...
Drugs: BafetinibEnzymes: S-phase kinase-associated protein 2Non-Ketotic Hyperglycinemia
smpdb.ca/view/SMP0125580DiseaseNon Ketotic Hyperglycinemeia (Glycine encephalopathy; Glycine cleavage system deficiency; NKH) is caused by mutations in several genes in the mitochondrial glycine cleavage system. These include the genes encoding P protein (GLDC), T pro...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 moreEnzymes: Betaine--homocysteine S-methyltransferase 1Ibrutinib
go.drugbank.com/drugs/DB09053ApprovedInvestigationalIt is designated as a targeted covalent drug and presented as a promising activity in B-cell malignancies in clinical trials. … Ibrutinib is a small molecule that acts as an irreversible potent inhibitor of Burton's tyrosine kinase.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-oneTralokinumab
go.drugbank.com/drugs/DB12169ApprovedInvestigationalWhile AD is a heterogenous condition with a variety of apparent genetic and environmental causes,[A242422] it is primarily driven by the pro-inflammatory cytokine interleukin-13 (IL-13). … [A242427] Tralokinumab is a fully human IgG4 monoclonal antibody targeted against IL-13.