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Displaying results 1141 - 1150 of 10000 in total
  1. Drug

    Abaloparatide

    go.drugbank.com/drugs/DB05084
    ApprovedInvestigational

    [L740] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended abaloparatide be granted marketing authorization in Europe [L43552] and the drug was fully authorized … [L740] It is a synthetic 34 amino acid peptide with 41% homology to human parathyroid hormone 1-34 and human PTHrP 1-34.

  2. Pathway

    Imatinib Inhibition of BCR-ABL

    smpdb.ca/view/SMP0031694
    Drug action

    Imatinib is a tyrosine kinase inhibitor used to treat cancers such as chronic myelogenous leukemia (CML), a cancer characterized by increased and unregulated growth of white blood cells in the bone marrow and the accumulation of these ce...

    Drugs: Imatinib
    Enzymes: S-phase kinase-associated protein 2
  3. Drug

    Nalmefene

    go.drugbank.com/drugs/DB06230
    ApprovedInvestigationalWithdrawn

    [L1024] In Europe, nalmefene oral tablets are used to reduce alcohol consumption in adults with alcohol dependence. … [L40684] It acts as an antagonist at the mu (μ)-opioid and delta (δ)-opioid receptors and a partial agonist at the kappa (κ)-opioid receptor.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: MORPHINAN-3,14-DIOL, 17-(CYCLOPROPYLMETHYL)-4,5-EPOXY-6-METHYLENE-, (5.ALPHA.)-, 17-(Cyclopropylmethyl)-4,5α-epoxy-6-methylenemorphinan-3,14-diol
  4. Drug

    Diroximel fumarate

    go.drugbank.com/drugs/DB14783
    ApprovedInvestigational

    [A176474] It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. … [A187535] Diroximel fumarate is a new drug from the fumarate class formulated to treat various relapsing forms of MS.

  5. Drug

    Efbemalenograstim alfa

    go.drugbank.com/drugs/DB18704
    ApprovedInvestigational

    This approval was contingent on positive results observed in two pivotal Phase 3 Studies GC-627-04 and GC-627-05 in the US and Europe respectively.[L48887] … Efbemalenograstim alfa is a long-acting recombinant fusion protein of granulocyte-colony stimulating factor (G-CSF) due to the addition of the Fc portion of human IgG2, allowing for once-per-cycle administration

    Synonyms: Rh g-csf fc fusion protein f-627, Recombinant dimeric g-csf fusion protein f627
  6. Target

    Neuronal acetylcholine receptor subunit alpha-7

    go.drugbank.com/bio_entities/BE0002341
    TargetHumans

    Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter … receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction.

    Synonyms: nAChR7
  7. Drug

    Zotepine

    go.drugbank.com/drugs/DB09225
    ApprovedWithdrawn

    [A31855] It has been used as an antipsychotic in Japan, India and some places in Europe like UK and Germany since 1980's.[A31857] Zotepine was never approved by the FDA. … Zotepine, with the formula (2-chloro-11-(2-dimethyl-amino-ethoxy)-dibenzo thiepin, is a neuroleptic drug. It was designed and synthesized by Fujisawa Pharmaceutical Co Ltd.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 3-RingProducts: ZOLEPTIL © 50 MG TABLETAS RECUBIERTAS.
  8. Pathway

    Isosorbide Mononitrate Action Pathway

    smpdb.ca/view/SMP0125275
    Drug action

    It is then metabolized in the cytosol into nitric oxide by P450 enzymes, xanthine oxidoreductase (XO), glutathione-S-transferase (GST), or cytosolic aldehyde dehydrogenase isoforms.

    Drugs: Nitric Oxide · Isosorbide mononitrate · Potassium cation · Calcium · Magnesium cation · Pyrophosphoric acid
    Enzymes: Glutathione S-transferase Mu 1
  9. Pathway

    Ruxolitinib Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126971
    Drug action

    Ruxolitinib is a medication used to manage and treat myelofibrosis, polycythemia vera, and steroid-refractory acute graft-versus-host disease. It is in the Janus Kinase inhibitor class of medications. Ruxolitinib is a selective and poten...

    Drugs: Ruxolitinib
    Enzymes: S-phase kinase-associated protein 2
  10. Drug

    Tauroursodeoxycholic acid

    go.drugbank.com/drugs/DB08834
    ApprovedInvestigationalWithdrawn

    [A249080] Tauroursodeoxycholic acid is currently used in Europe to treat and prevent gallstones as a bile acid derivative. … Tauroursodeoxycholic acid, also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid [A249070] that is produced in humans at a low concentration.