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Displaying results 1141 - 1150 of 2256 in total
  1. Drug

    N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine

    go.drugbank.com/drugs/DB13948
    Experimental

    25CN-NBOH (N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine) is a newly developed selective 5-HT2A agonist. It has been tested with regard to the head-twitch-response (HTR) model of 5-HT2A activity and effects on locomotion . It...

    Categories: Serotonin Receptor Agonists, Serotonin 5-HT2 Receptor Agonists
  2. Drug

    Gelatin

    go.drugbank.com/drugs/DB11242
    ApprovedInvestigationalVet approvedWithdrawn

    [A32432] As a thermoreversible hydrocolloid with a small gap between its melting and gelling temperatures, gelatin provides unique advantages over carbohydrate-based gelling agents. … Fish skins have a significant potential for the production of high-quality gelatin with different melting and gelling temperatures over a much larger range than mammalian gelatins but have a sufficiently

  3. Drug

    Ubrogepant

    go.drugbank.com/drugs/DB15328
    ApprovedInvestigational

    [erenumab], [fremanezumab], [galcanezumab]) have also been approved in recent years.[A189207] Ubrogepant was approved by Health Canada on November 10, 2022. … [L10926] It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine.

    Categories: Calcitonin Gene-Related Peptide Receptor Antagonists
  4. Drug

    Avanafil

    go.drugbank.com/drugs/DB06237
    Approved

    In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively

  5. Drug

    Cangrelor

    go.drugbank.com/drugs/DB06441
    ApprovedInvestigational

    An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an active drug not requiring metabolic conversion therefore providing a rapid onset

    Categories: Purinergic P2 Receptor Antagonists, Purinergic P2Y Receptor Antagonists
  6. Target

    High affinity immunoglobulin epsilon receptor subunit gamma

    go.drugbank.com/bio_entities/BE0000049
    TargetHumans

    As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. … As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset.

    Polypeptides: High affinity immunoglobulin epsilon receptor subunit gammaSynonyms: Fc receptor gamma-chain, IgE Fc receptor subunit gamma
  7. Target

    Gamma-aminobutyric acid receptor subunit rho-1

    go.drugbank.com/bio_entities/BE0000129
    TargetHumans

    Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:37659407). Rho-containing GABA-gated chlorid...

    Polypeptides: Gamma-aminobutyric acid receptor subunit rho-1Synonyms: GABA(C) receptor, GABA(A) receptor subunit rho-1
  8. Target

    Mast/stem cell growth factor receptor Kit

    go.drugbank.com/bio_entities/BE0000453
    TargetHumans

    KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. … Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B.

    Polypeptides: Mast/stem cell growth factor receptor Kit
  9. Target

    Gamma-aminobutyric acid receptor subunit alpha-4

    go.drugbank.com/bio_entities/BE0000478
    TargetHumans

    Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). GABA-gated chloride channels, also named GABA(A) receptors (...

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-4Synonyms: GABA(A) receptor subunit alpha-4
  10. Target

    Tyrosine-protein phosphatase non-receptor type 1

    go.drugbank.com/bio_entities/BE0000623
    TargetHumans

    May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET

    Polypeptides: Tyrosine-protein phosphatase non-receptor type 1