Mast/stem cell growth factor receptor Kit

BE0000453ProteinHumansKIT

Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and... It is acted on by 51 drugs in DrugBank.

Gene name
KIT
UniProtKB entry
P10721Swiss-Prot
Cellular location
Cell membrane
Residues / weight
976 residues · 109,864 Da
Also known as
2.7.10.1 · p145 c-kit · PBT · Piebald trait protein · Proto-oncogene c-Kit

Resolves to

Protein
UniProtP10721UniProt nameKIT_HUMAN
Gene
HGNCHGNC:6342NCBI Gene3815GenBank34085GeneCardsKIT
Pharmacology
IUPHAR/GtoPdb1805KEGGhsa:3815
Structure
PDB1PKGPDB1T45PDB1T46
Drugs

What you can answer from here — as of September 07, 2019

51DrugsApproved to experimental, with action, bond type and pharmacological action
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162Clinical trialsTrials of drugs acting on it, by phase and status
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21GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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239+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mast/stem cell growth factor receptor Kit, how selective are they, and which programs against it are still in active trials?

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