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Displaying results 1151 - 1160 of 10000 in total
  1. Drug

    Glofitamab

    go.drugbank.com/drugs/DB16371
    ApprovedInvestigational

    ) after two or more lines of systemic therapy. … , after two or more lines of systemic therapy under accelerated approval based on response rate and durability of response.

  2. Target

    Serine/threonine-protein kinase Nek2

    go.drugbank.com/bio_entities/BE0003796
    TargetHumans

    Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. … Involved in the regulation of centrosome disjunction (PubMed:26220856).

    Synonyms: Never in mitosis A-related kinase 2
  3. Target

    Splicing factor 1

    go.drugbank.com/bio_entities/BE0009118
    TargetHumans

    Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor

    Synonyms: Zinc finger gene in MEN1 locus
  4. Drug

    Tenofovir disoproxil

    go.drugbank.com/drugs/DB00300
    ApprovedInvestigational

    This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label]. … Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase

    Mixtures: Symfi Lo, Symfi LoCategories: Antivirals used in combination for the treatment of HIV infections
  5. Drug

    Triethylenetetramine

    go.drugbank.com/drugs/DB06824
    ApprovedInvestigational

    Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, [spermidine] and [spermine]. … [A19333] Initially approved by the FDA in 1985 as a second-line treatment for Wilson's disease,[A19334] TETA is currently indicated to treat adults with stable Wilson’s disease who are de-coppered and

    Categories: Compounds used in a research, industrial, or household setting
  6. Drug

    Pseudoephedrine

    go.drugbank.com/drugs/DB00852
    Approved

    [A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. … Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.

    Mixtures: ACTIGRIP GIORNO & NOTTE, VICKS FLU GIORNO NOTTECategories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates
  7. Drug

    Axicabtagene ciloleucel

    go.drugbank.com/drugs/DB13915
    ApprovedInvestigational

    The drug has a unique mechanism of action, as it utilizes the patient's own T cells, which play a central role in immune response to cancer. … It is marketed under the brand name Yescarta and is used to treat large B-cell lymphomas and follicular lymphoma in adults.

    Synonyms: Autologous T cells transduced with retroviral vector encoding an anti-CD-19 CD28/CD3-zeta chimeric antigen receptor
  8. Drug

    Indapamide

    go.drugbank.com/drugs/DB00808
    ApprovedInvestigational

    [A204155] Thiazide-like diuretics such as indapamide are a valuable tool for the treatment of hypertension and continue to grow in popularity, falling behind only ACE inhibitors in terms of prescription … agents may be required in order to achieve blood pressure targets.

    Mixtures: PERINDO IN 1A PHA4/1.25MG, PERINDO IN 1A PHA4/1.25MG
  9. Drug

    Octocrylene

    go.drugbank.com/drugs/DB09535
    Approved

    Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. … What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin damage from prolonged sun exposure.

    Mixtures: La Prairie Skin Caviar Essence-In-Foundation SPF 25 Peche, La Prairie Skin Caviar Essence In Foundation SPF 25 Pure Ivory
  10. Drug

    Monopotassium phosphate

    go.drugbank.com/drugs/DB09413
    ApprovedInvestigationalVet approved

    It is a source of phosphorus and potassium as well as a buffering agent. It can be used in fertilizer mixtures to reduce escape of ammonia by keeping pH low. … Monopotassium phosphate, MKP, (also potassium dihydrogenphosphate, KDP, or monobasic potassium phosphate), KH2PO4, is a soluble salt of potassium and the dihydrogen phosphate ion.

    Mixtures: NUTRIFLEX PERI IN 2000ML TWIN-FLEX, NUTRIFLEX SPECIAL IN 1000ML TWIN FLEXCategories: Compounds used in a research, industrial, or household setting