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Displaying results 1161 - 1170 of 10000 in total
  1. Target

    T cell receptor delta variable 2

    go.drugbank.com/bio_entities/BE0023749
    TargetHumans

    V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447).

    Polypeptides: T cell receptor delta variable 2
  2. Target

    Taste receptor type 2 member 3

    go.drugbank.com/bio_entities/BE0023234
    TargetHumans

    Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5

    Polypeptides: Taste receptor type 2 member 3Function: bitter taste receptor activity
  3. Drug

    Volanesorsen

    go.drugbank.com/drugs/DB15067
    Approved

    [L16621] This drug is not commonly prescribed as it is used as an adjunct to diet in patients at high risk for pancreatitis, who have had inadequate response to triglyceride lowering therapy. … Volanesorsen is an antisense oligonucleotide that binds to apoC-III mRNA to prevent its translation.

  4. Target

    GABA(A) Receptor Benzodiazepine Binding Site

    go.drugbank.com/bio_entities/BE0008668
    TargetHumans

    GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity). … GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity)

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-2Synonyms: GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-2
  5. Target

    Receptor tyrosine-protein kinase erbB-3

    go.drugbank.com/bio_entities/BE0009917
    TargetHumans

    Tyrosine kinase receptor that, despite substitutions of key catalytic residues in the kinase domain, retains residual catalytic activity enabling autophosphorylation (PubMed:9148746, PubMed:20351256).

    Polypeptides: Receptor tyrosine-protein kinase erbB-3Synonyms: Tyrosine kinase-type cell surface receptor HER3
  6. Target

    Receptor-type tyrosine-protein phosphatase beta

    go.drugbank.com/bio_entities/BE0003769
    TargetHumans

    Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadhe...

    Polypeptides: Receptor-type tyrosine-protein phosphatase beta
  7. Target

    Vascular endothelial growth factor receptor 1

    go.drugbank.com/bio_entities/BE0000029
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival

    Polypeptides: Vascular endothelial growth factor receptor 1Synonyms: Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor
  8. Target

    Gamma-aminobutyric acid receptor subunit delta

    go.drugbank.com/bio_entities/BE0003599
    TargetHumans

    Delta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). GABA-gated chloride channels, also named GABA(A) receptors (...

    Polypeptides: Gamma-aminobutyric acid receptor subunit deltaSynonyms: GABA(A) receptor subunit delta
  9. Target

    Bone morphogenetic protein receptor type-1B

    go.drugbank.com/bio_entities/BE0009415
    TargetHumans

    Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction … On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.

    Polypeptides: Bone morphogenetic protein receptor type-1BSynonyms: BMP type-1B receptor
  10. Target

    Membrane-associated progesterone receptor component 1

    go.drugbank.com/bio_entities/BE0004896
    TargetHumans

    Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021)

    Polypeptides: Membrane-associated progesterone receptor component 1