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Poly(A) polymerase gamma
go.drugbank.com/bio_entities/BE0018981TargetHumansResponsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA
Polypeptides: Poly(A) polymerase gammaSynonyms: Neo-poly(A) polymeraseDimethyl fumarate
go.drugbank.com/drugs/DB08908ApprovedInvestigationalDimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis. … It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated
Synonyms: (E)-But-2-enedioic acid dimethyl esterProducts: D-FUMARIC 240 CAPSULAS DE LIBERACIÓN RETARDADA 240 MG, D-FUMARIC 120 CAPSULAS DE LIBERACION RETARDADA 120 MGLactulose
go.drugbank.com/drugs/DB00581ApprovedInvestigationalwithheld from patients diagnosed with PSE in a placebo study, the substance may just be one of many options available for treating constipation and its efficacy in managing PSE may never be formally confirmed … [L6202] Especially considering the use of lactulose as a laxative is typically only considered after lifestyle and dietary modifications fail and the fact that lactulose therapy cannot be ethically
Synonyms: 4-O-beta-D-Galactopyranosyl-D-fructofuranose, 4-O-beta-D-Galactopyranosyl-D-fructoseProducts: FLOROLAC 670MG/ML LOES Z E, LACTULOSE AL SIRUPInterferon alfa-2a
go.drugbank.com/drugs/DB00034ApprovedInvestigationalWithdrawnInterferon a (human leukocyte protein moiety reduced). A type I interferon consisting of 165 amino acid residues with lysine in position 23. … It is used extensively as an antiviral or antineoplastic agent. An oral form is being developed by Amarillo Biosciences.
Synonyms: Interferon Alfa 2A, Interferon alfa-2aInternational brands: Roferon ALipid A palmitoyltransferase PagP
go.drugbank.com/bio_entities/BE0001965TargetEscherichia coli (strain K12)Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors.
Polypeptides: Lipid A palmitoyltransferase PagPSynonyms: Lipid A acylation proteinDihydroorotate dehydrogenase A (fumarate)
go.drugbank.com/bio_entities/BE0002008TargetLactococcus lactis subsp. cremorisCatalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
Polypeptides: Dihydroorotate dehydrogenase A (fumarate)Synonyms: DHOD ABCL11 transcription factor A
go.drugbank.com/bio_entities/BE0019545TargetHumansMay function as a modulator of the transcriptional repression activity of NR2F2 (By similarity) … May play a role in hematopoiesis (By similarity). Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity).
Polypeptides: BCL11 transcription factor AAlprostadil
go.drugbank.com/drugs/DB00770ApprovedInvestigationalThis drug causes vasodilation by directly affecting vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. … Alprostadil is a chemically-identical synthetic form of prostaglandin E1 (PGE1), a potent vasodilator produced endogenously.
Categories: Prostaglandins ESynonyms: PGE-1, (11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acidCholecystokinin receptor type A
go.drugbank.com/bio_entities/BE0000402TargetHumansThis receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system … Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system.
Polypeptides: Cholecystokinin receptor type ASynonyms: CCK-A receptor