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Levoketoconazole
go.drugbank.com/drugs/DB05667ApprovedIt possesses most of the inhibitory effect towards steroidogenic enzymes, making it an attractive candidate for CS treatment with a potentially lower toxicity profile than its racemate. … Still, toxicity has limited its use, notably hepatic toxicity and a tendency to prolong the QT interval.[A244083] Levoketoconazole is one of two enantiomers present in racemic [ketoconazole].
Categories: MATE 1 Inhibitors, P-glycoprotein inhibitorsEncorafenib
go.drugbank.com/drugs/DB11718ApprovedInvestigationalBRAF V600E or V600K mutation, as detected by an FDA-approved test. … [L12216] This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and secretion.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: BRAFTOVI® 75 MG CÁPSULASLactulose
go.drugbank.com/drugs/DB00581ApprovedInvestigationalwithheld from patients diagnosed with PSE in a placebo study, the substance may just be one of many options available for treating constipation and its efficacy in managing PSE may never be formally confirmed … Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic
Synonyms: 4-O-beta-D-Galactopyranosyl-D-fructofuranose, 4-O-beta-D-Galactopyranosyl-D-fructoseProducts: LACTUS SYRUP 66% w/v, FLOROLAC 670MG/ML LOES Z EEtranacogene dezaparvovec
go.drugbank.com/drugs/DB16791ApprovedInvestigationalHemophilia B - also called factor IX deficiency or Christmas disease - is an X-linked genetic disorder resulting in an absence or deficiency of clotting factor IX. … [L44181] Symptoms of hemophilia B, therefore, involve a heightened susceptibility to bleeding episodes - in mild cases, bleeding may only occur after injury, while in more severe cases bleeding may occur
Elivaldogene autotemcel
go.drugbank.com/drugs/DB16746ApprovedIt is used to provide functional copies of human adrenoleukodystrophy protein (ALDP) in patients with adrenoleukodystrophy,[L39491] an X-linked genetic disorder characterized by missing or non-functional … [L40298] Cerebral adrenoleukodystrophy is an inflammatory cerebral phenotype that more commonly affects young men: it is associated with progressive brain function loss and poor survival rates without
International brands: Lenti-DFexinidazole
go.drugbank.com/drugs/DB12265ApprovedTransmitted by the bite of an infected tsetse fly, HAT is biphasic with a first (hemolymphatic) stage that progresses to a second (meningoencephalitic) stage in which patients experience progressively … Human African trypanosomiasis (HAT, also colloquially referred to as sleeping sickness), caused by _T. brucei gambiense_ and _T. brucei rhodesiense_, remains a moderate risk (>1/10,000 inhabitants per
Categories: MATE 2-K Inhibitors, MATE 1 Inhibitors2-deoxyglucose
go.drugbank.com/drugs/DB08831InvestigationalTherapeutically, 2-deoxyglucose is an investigational drug that is being studied as an anticancer and antiviral agent. … As an experimental drug, 2-deoxyglucose was demonstrated to work as an anticonvulsant in temporal lobe epilepsy.
Synonyms: 2-deoxy-D-glucose, 2-Deoxy-D-arabino-hexoseDroxicam
go.drugbank.com/drugs/DB09215ApprovedWithdrawnDroxicam is an oxicam non-steroidal anti-inflammatory drug and a prodrug of [DB00554].
Categories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 1-RingStatus Epilepticus
go.drugbank.com/conditions/DBCOND0028922Synonyms: Grand mal status, Grand mal status, epilepticFerrous sulfate anhydrous
go.drugbank.com/drugs/DB13257ApprovedInvestigational[A190528] Ferrous sulfate is a synthetic agent used in the treatment of iron deficiency. It is the gold standard of oral iron therapy in the UK and many other countries.[L2234,L2246] … Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age.
Mixtures: TARDYFERON FOL DEP EISEN, TARDYFERON FOL DEP EISENSynonyms: iron sulfate (1:1), iron(2+) sulfate (anhydrous)