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Displaying results 111 - 120 of 124 in total
  1. Pathway

    Codeine Opioid Action Pathway

    smpdb.ca/view/SMP0122959
    Drug action

    Codeine is an opioid agonist used for analgesia (pain-relief) and sedation similar to other opioid derivatives like morphine, methadone, fentanyl, hydrocodone and oxycodone. Codeine, like morphine is derived from the poppy plant, Papaver...

    Drugs: NADH · ATP · Morphine · Codeine · Calcium · Magnesium cation +6 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  2. Pathway

    Homocarnosinosis

    smpdb.ca/view/SMP0125785
    Disease

    Homocarnosinosis is caused by an inherited defect in serum carnosinase, which converts homocarnosine to GABA (gamma aminobutyric acid).

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 more
  3. Pathway

    Homocarnosinosis

    smpdb.ca/view/SMP0000385
    Disease

    Homocarnosinosis is caused by an inherited defect in serum carnosinase, which converts homocarnosine to GABA (gamma aminobutyric acid).

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 more
  4. Pathway

    2-Hydroxyglutric Aciduria (D and L Form)

    smpdb.ca/view/SMP0000136
    Disease

    A deficiency in this enzyme results in accumulation of D-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; oxoglutaric acid in urine; and gabba-aminobutyric acid in spinal fluid. … L-2-Hydroxyglutaric Aciduria (D-2-Hydroxyglutaric Aciduria ) is an autosomal recessive disease caused by a mutation in the L2HGDH gene which codes for L-2-Hydroxygluarate dehydrogenase.

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 more
  5. Pathway

    4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency

    smpdb.ca/view/SMP0125784
    Disease

    4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency (SSADH; Gamma-hydroxybutyric acidemia) inhibits the formation of succinate from GABA. … This deficiency results in urinary excretion of 4-hydroxybutyric acid. In vivo proton MR also indicates elevated GABA levels as compared with an age-matched control.

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 more
  6. Pathway

    4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency

    smpdb.ca/view/SMP0000243
    Disease

    4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency (SSADH; Gamma-hydroxybutyric acidemia) inhibits the formation of succinate from GABA. … This deficiency results in urinary excretion of 4-hydroxybutyric acid. In vivo proton MR also indicates elevated GABA levels as compared with an age-matched control.

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 more
  7. Pathway

    Glutamate Metabolism

    smpdb.ca/view/SMP0000072
    Metabolic

    Glutamate is one of the non-essential amino acids that is produced by the body. Glutamate is precursor for many nucleic acids and proteins in addition to its role in the central nervous system. … Dysfunctional glutamate metabolism may cause disorders such as: gyrate atrophy, hyperammonemia, γ-hydoxybutyric aciduria, hemolytic anemia, and 5-oxoprolinuria.

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 more
  8. Pathway

    Succinic Semialdehyde Dehydrogenase Deficiency

    smpdb.ca/view/SMP0000567
    Disease

    With reduced GABA activity, oxidation of succinic semialdehyde (SSA) to succinic acid is impaired causing a build up of SSA and ultimately it’s downstream metabolite γ-hydroxybutyric acid (GHB). … Succinic Semialdehyde Dehydrogenase (SSADH) deficiency is a rare autosomal recessive inherited disorder affecting the metabolism of γ-aminobutyric acid (GABA).

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 more
  9. Pathway

    Hyperinsulinism-Hyperammonemia Syndrome

    smpdb.ca/view/SMP0125787
    Disease

    Hyperinsulinism-hyperammonemia syndrome (HHS; Glutamate dehydrogenase 1; GLUD1), an inherited condition, is caused by a defect in the GLUD1 gene which codes for mitochondrial glutamate dehydrogenase 1. It is a mitochondrial matrix enzyme...

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 more
  10. Pathway

    Hyperinsulinism-Hyperammonemia Syndrome

    smpdb.ca/view/SMP0000339
    Disease

    Hyperinsulinism-hyperammonemia syndrome (HHS; Glutamate dehydrogenase 1; GLUD1), an inherited condition, is caused by a defect in the GLUD1 gene which codes for mitochondrial glutamate dehydrogenase 1. It is a mitochondrial matrix enzyme...

    Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 more