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1-phosphatidylinositol 3-phosphate 5-kinase
go.drugbank.com/bio_entities/BE0021269TargetHumansPlays a key role in the processing and presentation of antigens by major histocompatibility complex class II (MHC class II) mediated by CTSS (PubMed:30612035). … Has serine-protein kinase activity and is able to autophosphorylate and transphosphorylate.
Synonyms: PIPkin-III, Type III PIP kinaseDNA ligase 3
go.drugbank.com/bio_entities/BE0000167TargetHumansand alkylating agents. … Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation
Synonyms: DNA ligase IIIJunction plakoglobin
go.drugbank.com/bio_entities/BE0009084TargetHumansThe membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. … The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques.
Synonyms: Desmoplakin IIITubulin beta-3 chain
go.drugbank.com/bio_entities/BE0001415TargetHumansTUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). … Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977
Synonyms: Tubulin beta-IIICytochrome b-c1 complex subunit 7
go.drugbank.com/bio_entities/BE0003860TargetHumansThe respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase … and the ATP synthase.
Synonyms: Complex III subunit 7, Complex III subunit VIICAMPATH-1 antigen
go.drugbank.com/bio_entities/BE0000083TargetHumansMay play a role in carrying and orienting carbohydrate, as well as having a more specific role
Synonyms: Human epididymis-specific protein 5Beta sliding clamp
go.drugbank.com/bio_entities/BE0003771TargetEscherichia coli (strain K12)Initially characterized for its ability to contact the alpha subunit (dnaE) of DNA polymerase III (Pol III), tethering it to the DNA and conferring very high processivity (PubMed:2040637). … A single clamp can bind both Pol III and IV, allowing the repair Pol IV to access DNA when it is damaged and needs to be fixed, a process the replicative polymerase cannot perform; when DNA is repaired
Synonyms: DNA polymerase III subunit beta, DNA polymerase III beta sliding clamp subunitCalcium/calmodulin-dependent protein kinase type 1G
go.drugbank.com/bio_entities/BE0004147TargetHumansCalcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity)
Synonyms: CLICK III, CaMK-like CREB kinase IIICytochrome c oxidase subunit 3
go.drugbank.com/bio_entities/BE0003987TargetHumansThe respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase … The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix
Synonyms: Cytochrome c oxidase polypeptide IIIMetallo-beta-lactamase L1 type 3
go.drugbank.com/bio_entities/BE0003355TargetEnzymePseudomonas maltophiliaConfers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
Synonyms: Beta-lactamase type III, Metallo-beta-lactamase L1 type III