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Pantoprazole Action Pathway
smpdb.ca/view/SMP0000228Drug actionBecause the drug binds covalently, its effects are dose-dependent and last much longer than similar drugs that bind to the protein non-covalently. … Pantoprazole is used to manage gastroesophageal reflux disease, to prevent stomach ulcers, and can be used to help treat the effects of a H. pylori infection.
Enzymes: Chloride intracellular channel protein 2Nizatidine Action Pathway
smpdb.ca/view/SMP0000233Drug actionBlocking of histamine binding to histamine H2 receptor can reduce the secretion of nocturnal and basal gastric acid.
Enzymes: Chloride intracellular channel protein 2Metiamide Action Pathway
smpdb.ca/view/SMP0000735Drug actionBinding and inhibition of histamine H2-receptor can lead to decreased gastric acid secretion so that lowering gastric volume as well as acidity. … Metiamide is a histamine H2-receptor antagonist that can bind and inhibit histamine H2-receptor to prevent the histamine effects on basolateral memrbane in gastric parietal cell.
Enzymes: Chloride intracellular channel protein 2Omeprazole Action Pathway (old)
smpdb.ca/view/SMP0000226Drug actionLosec and Zegerid, is a proton pump inhibitor (PPI) class drug that suppresses the final step in gastric acid production, and was the first proton pump inhibitor to e developed. … In this pathway, omeprazole is taken orally and is oxidized in the stomach to form the active metabolite of omeprazole.
Enzymes: Chloride intracellular channel protein 2Lansoprazole Action Pathway (old)
smpdb.ca/view/SMP0000227Drug actionIn this pathway, lansoprazole is taken orally and is oxidized in the stomach to form the active metabolite of lansoprazole. … Because the drug binds covalently, its effects are dose-dependent and last much longer than similar drugs that bind to the protein non-covalently.
Enzymes: Chloride intracellular channel protein 2Ranitidine Action Pathway
smpdb.ca/view/SMP0000230Drug actionA chloride ion is transported into the gastric endothelial cell through a chloride anion exchanger and is transported out of the cell through a chloride intracellular channel protein 2, back into the gastric … The potassium transporting ATPase also converts water and ATP to a phosphate molecule and ADP. Alongside the transporters, potassium is brought into the cell.
Enzymes: Chloride intracellular channel protein 2Famotidine Action Pathway
smpdb.ca/view/SMP0000231Drug actionBinding of famotidine can effectively inhibit the histamine effects, which lead to reduced nocturnal gastric acid and basal secretion; it can also decrease gastric volume, gastric acid and acidity. … Famotidine (also known as Pepcid) can bind and inhibit histamine H2 receptor on parietal cell's basolateral membrane.
Enzymes: Chloride intracellular channel protein 2Cimetidine Action Pathway
smpdb.ca/view/SMP0000232Drug actionCimetidine also helps to block pepsin and gastrin output, and due to the inhibition of gastric acid secretion, it is typically used to treat heartburn and ulcers. … This blocks histamine effects, resulting in reduced gastric acid secretion and a reduction in gastric volume and acidity.
Enzymes: Chloride intracellular channel protein 2Gastric Acid Production
smpdb.ca/view/SMP0000589PhysiologicalHowever, it is also constituted of potassium chloride (KCl) and sodium chloride (NaCl). … Moreover, the chloride and potassium ions are transported into the stomach lumen through their own channels so that hydrogen ions and/or potassium ions can form an ionic bond with chloride ions to form
Enzymes: Chloride intracellular channel protein 2Pirenzepine M1 Ulcer Treatment Action Pathway
smpdb.ca/view/SMP0124706Drug actionPirenzepine acts on muscarinic acetylcholine receptor M1 antagonizing it and eliciting inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels. … It can be used along with antacids to treat peptic ulcers, it can also be used to prevent nausea, vomiting and motion sickness.
Enzymes: Chloride anion exchanger