Metiamide

DB08805ExperimentalSmall molecule

Metiamide is an H-2 receptor antagonist derived from burimamide. It was an intermediate product on the path to developing cimetidine.

Mechanism: Metiamide binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.
Curator reviewed
Primary indication: Potential in the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion.Curator reviewed
Formula / weight: C₉H₁₆N₄S₂ · 244.38 g/mol (avg)
Also known as: Methiamide
Code names: SK&F 92058

Resolves to

Compound

Structure

InChIKeyFPBPLBWLMYGIQR-UHFFFAOYSA-NSMILESCNC(=S)NCCSCC1=C(C)NC=N1

Targets

What you can answer from here — as of February 21, 2021

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

124Drug interactionsStructured to mechanism, not free text

2+ReferencesStructured and connected to the statements they support

Which drugs share a target with Metiamide, and which of those have an active Phase 3 trial?

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