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Displaying results 111 - 120 of 134109 in total
  1. Pathway

    Dicoumarol Action Pathway

    smpdb.ca/view/SMP0000656
    Drug action

    Vitamin K-dependent coagulation factors (II, VII, IX, and X) requires its cofactor, vitamin K to facilitate the activation and gamma-carboxylation. … Inhibition of vitamin K reductase results in reduced concentration of vitamin KH2, which will ultimately lead to decreased coagulability of the blood and reduced cleavage of fibrinogen into fibrin.

    Drugs: Dicoumarol · Phylloquinone · Calcium
    Enzymes: Collagen alpha-1(I) chain
  2. Pathway

    Streptokinase Action Pathway

    smpdb.ca/view/SMP0000282
    Drug action

    It is also activated through plasma prekallikrein and coagulation factor XIIa which activate plasma kallikrein, which then pairs with coagulation factor XII simultaneously with the previous collagen chain … This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X.

    Drugs: Streptokinase · Phylloquinone · Calcium
    Enzymes: Collagen alpha-1(I) chain
  3. Pathway

    Urokinase Action Pathway

    smpdb.ca/view/SMP0000284
    Drug action

    It is also activated through plasma prekallikrein and coagulation factor XIIa which activate plasma kallikrein, which then pairs with coagulation factor XII simultaneously with the previous collagen chain … This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X.

    Drugs: Urokinase · Phylloquinone · Calcium
    Enzymes: Collagen alpha-1(I) chain
  4. Pathway

    Reteplase Action Pathway

    smpdb.ca/view/SMP0000285
    Drug action

    It is also activated through plasma prekallikrein and coagulation factor XIIa which activate plasma kallikrein, which then pairs with coagulation factor XII simultaneously with the previous collagen chain … This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X.

    Drugs: Reteplase · Phylloquinone · Calcium
    Enzymes: Collagen alpha-1(I) chain
  5. Pathway

    Warfarin Action Pathway (New)

    smpdb.ca/view/SMP0124982
    Drug action

    Indicated for: prophylaxis and treatment of venous thromboembolism and related pulmonary embolism, prophylaxis and treatment of thromboembolism associated with atrial fibrillation, prophylaxis and treatment … Additional adverse effects such as necrosis, purple toe syndrome, osteoporosis, valve and artery calcification, and drug interactions have also been documented with warfarin use.

    Drugs: Warfarin · Phylloquinone · Calcium
    Enzymes: Collagen alpha-1(I) chain
  6. Pathway

    Phenprocoumon Action Pathway

    smpdb.ca/view/SMP0000271
    Drug action

    into fibrin and decreased coagulability of the blood. … As vitamin K is a cofactor for the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulation factors (II, VII, IX, and X), this ultimately results in reduced cleavage of fibrinogen

    Drugs: Phenprocoumon · Phylloquinone · Calcium
    Enzymes: Collagen alpha-1(I) chain
  7. Pathway

    Acenocoumarol Action Pathway

    smpdb.ca/view/SMP0000269
    Drug action

    Vitamin K-dependent coagulation factors (II, VII, IX, and X) requires its cofactor, vitamin K to facilitate the activation and gamma-carboxylation. … Inhibition of vitamin K reductase results in reduced concentration of vitamin KH2, which will ultimately lead to decreased coagulability of the blood and reduced cleavage of fibrinogen into fibrin.

    Drugs: Phylloquinone · Calcium · Acenocoumarol
    Enzymes: Collagen alpha-1(I) chain
  8. Pathway

    Dicumarol Action Pathway

    smpdb.ca/view/SMP0000270
    Drug action

    Vitamin K-dependent coagulation factors (II, VII, IX, and X) requires its cofactor, vitamin K to facilitate the activation and gamma-carboxylation. … Inhibition of vitamin K reductase results in reduced concentration of vitamin KH2, which will ultimately lead to decreased coagulability of the blood and reduced cleavage of fibrinogen into fibrin.

    Drugs: Dicoumarol · Phylloquinone · Calcium
    Enzymes: Collagen alpha-1(I) chain
  9. Pathway

    Ximelagatran Action Pathway

    smpdb.ca/view/SMP0000279
    Drug action

    It is also activated through plasma prekallikrein and coagulation factor XIIa which activate plasma kallikrein, which then pairs with coagulation factor XII simultaneously with the previous collagen chain … Coagulation factor XIIa is introduced through chain of activation starting in the endothelial cell with collagen alpha-1 (I) chain, which paired with coagulation factor XII activates coagulation factor

    Drugs: Phylloquinone · Calcium · Ximelagatran
    Enzymes: Collagen alpha-1(I) chain
  10. Pathway

    Tranexamic Acid Action Pathway

    smpdb.ca/view/SMP0000287
    Drug action

    It is also activated through plasma prekallikrein and coagulation factor XIIa which activate plasma kallikrein, which then pairs with coagulation factor XII simultaneously with the previous collagen chain … This enzyme also catalyzes precursors of prothrombin and coagulation factors VII, IX and X to prothrombin, and coagulation factors VII, IX and X.

    Drugs: Tranexamic acid · Phylloquinone · Calcium
    Enzymes: Collagen alpha-1(I) chain