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Displaying results 1211 - 1220 of 10000 in total
  1. Target

    Calcitonin gene-related peptides

    go.drugbank.com/bio_entities/BE0010233
    TargetHumans

    CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed:38603770)

    Synonyms: CGRP-I, Calcitonin gene-related peptide I
  2. Drug

    Salicylamide

    go.drugbank.com/drugs/DB08797
    Approved

    Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. … It has similar medicinal uses to aspirin. Salicylamide is used in combination with both aspirin and caffeine in the over-the-counter pain remedies

    Mixtures: CON-Z-LIN TABLETCategories: Non COX-2 selective NSAIDS, Analgesics, Non-Narcotic
  3. Drug

    Nedosiran

    go.drugbank.com/drugs/DB17635
    ApprovedInvestigational

    [A261685] Nedosiran was approved by the FDA on October 2<sup>nd</sup>, 2023, under the brand name RIVFLOZA to lower urinary oxalate levels in children 9 years of age and older and adults with primary … [A261690] Oxalate, particularly calcium oxalate, precipitation is the main cause of kidney stones formation; therefore, blocking the production of oxalate can help alleviate renal symptoms.

  4. Drug

    Mevonlerbart

    go.drugbank.com/drugs/DB19416
    Investigational

    Mevonlerbart is under investigation in clinical trial NCT06602726 (A Study to Demonstrate How Well REGN1908-1909 Works in Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Cat Allergy

    Synonyms: Anti-cat allergen fel d 1 monoclonal anitbody regn-1909, immunoglobulin G4-kappa, anti-[Fel d 1 (Felis silvestris catus (domestic cat) allergen 1)], Homo sapiens monoclonal antibody
  5. Target

    Pikromycin polyketide synthase component PikAIV

    go.drugbank.com/bio_entities/BE0004058
    TargetStreptomyces venezuelae

    The thioesterase can use a series of diketide-N-acetylcysteamine (SNAC) thioesters, but has a strong preference for the 2-methyl-3-ketopentanoyl-SNAC over the stereoisomers of 2-methyl-3-hydroxyacyl-SNAC

    Synonyms: Type I polyketide synthase PikAIV, Type I modular polyketide synthase PikAIV
  6. Target

    Apolipoproteins

    go.drugbank.com/bio_entities/BE0010065
    CarrierTargetHumans

    Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. … Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid

    Polypeptides: Apolipoprotein A-ISynonyms: ApoA-I, ApoL-I
  7. Drug

    Rifamycin

    go.drugbank.com/drugs/DB11753
    ApprovedInvestigationalWithdrawn

    [A39986] Rifamycin was further developed by Cosmo Technologies Ltd and approved in November 16, 2018 by the FDA as a prescription drug after being granted the designation of Qualified Infectious Disease … [L4800] This drug was also sent for review to the EMA in 2015 by Dr. Falk Pharma Gmbh and it was granted a waiver for the tested conditions.[L4801]

    Mixtures: RİF 250 MG/3 ML IM ENJEKSİYONLUK ÇÖZELTİ (1 AMPUL), RİF 250 MG/3 ML IM ENJEKSİYONLUK ÇÖZELTİ (100 AMPUL)Categories: MATE 1 Inhibitors, P-glycoprotein inhibitors
  8. Drug

    Norfloxacin

    go.drugbank.com/drugs/DB01059
    ApprovedInvestigational

    A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.

    Categories: Topoisomerase II Inhibitors, 4-QuinolonesSynonyms: 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsäure, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
  9. Target

    Annexin A2

    go.drugbank.com/bio_entities/BE0001170
    TargetHumans

    Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed

    Synonyms: Protein I, Calpactin I heavy chain
  10. Drug

    Dorzolamide

    go.drugbank.com/drugs/DB00869
    ApprovedInvestigational

    [L11377] It works by blocking an enzyme in the ciliary process that regulates ion balance and fluid pressure in the eyes. … Dorzolamide is a non-bacteriostatic sulfonamide derivative [A1304] and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and

    Mixtures: DORZOLOL® UD, Van-dorzolamide-timololCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring