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Receptor-interacting serine/threonine-protein kinase 4
go.drugbank.com/bio_entities/BE0009533TargetHumansSerine/threonine protein kinase (By similarity). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (By s...
Polypeptides: Receptor-interacting serine/threonine-protein kinase 4Synonyms: Ankyrin repeat domain-containing protein 3Tyrosine-protein phosphatase non-receptor type 12
go.drugbank.com/bio_entities/BE0009940TargetHumansDephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2...
Polypeptides: Tyrosine-protein phosphatase non-receptor type 12Tumor necrosis factor receptor superfamily member 6
go.drugbank.com/bio_entities/BE0010463TargetHumansReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor.
Polypeptides: Tumor necrosis factor receptor superfamily member 6Synonyms: FASLG receptorTumor necrosis factor receptor superfamily member 4
go.drugbank.com/bio_entities/BE0010535TargetHumansReceptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity
Polypeptides: Tumor necrosis factor receptor superfamily member 4Synonyms: OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptorTumor necrosis factor receptor superfamily member 10A
go.drugbank.com/bio_entities/BE0010564TargetHumansReceptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor.
Polypeptides: Tumor necrosis factor receptor superfamily member 10ASynonyms: Death receptor 4, TRAIL receptor 1Inactive tyrosine-protein kinase transmembrane receptor ROR1
go.drugbank.com/bio_entities/BE0010828TargetHumansReceptor for ligand WNT5A which activates downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350).
Polypeptides: Inactive tyrosine-protein kinase transmembrane receptor ROR1Synonyms: Neurotrophic tyrosine kinase, receptor-related 1Macrophage scavenger receptor types I and II
go.drugbank.com/bio_entities/BE0010942TargetHumansMembrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands.
Polypeptides: Macrophage scavenger receptor types I and IISynonyms: Scavenger receptor class A member 1, Macrophage acetylated LDL receptor I and IITriggering receptor expressed on myeloid cells 2
go.drugbank.com/bio_entities/BE0020451TargetHumansIn dendritic cells, receptor of SEMA6D with PLEXNA1 as coreceptor and mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640). … Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849).
Polypeptides: Triggering receptor expressed on myeloid cells 2Synonyms: Triggering receptor expressed on monocytes 2T cell receptor beta variable 5-6
go.drugbank.com/bio_entities/BE0023691TargetHumansV region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).
Polypeptides: T cell receptor beta variable 5-6Tegaserod
go.drugbank.com/drugs/DB01079ApprovedWithdrawnNovartis' brand name Zelnorm (tegaserod) had originally received approval from the US FDA in 2002 for the treatment of irritable bowel syndrome with constipation (IBS-C). It was, however, voluntarily withdrawn from widespread use in the ...
Categories: Serotonin-4 Receptor Agonist, Serotonin 4 Receptor Agonists