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Trimetazidine
go.drugbank.com/drugs/DB09069ApprovedInvestigational[A233255,A233260] Acidic conditions, caused by anaerobic metabolism and fatty acid oxidation, in response to myocardial ischemia, activate sodium-hydrogen and sodium-calcium antiport systems. … [A233215] It is hypothesized that trimetazidine inhibits 3-ketoacyl coenzyme A thiolase, which decreases fatty acid oxidation but not glucose metabolism, preventing the acidic conditions that exacerbate
Products: AXINOL TABLET 20MG, Metazine Tablet 20mgEnfortumab vedotin
go.drugbank.com/drugs/DB13007ApprovedInvestigational[L10836] It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protease-cleavable … The clinical development of enfortumab vedotin was the result of a collaboration between Astellas Pharma and Seattle Genetics [A188868] and it was first approved for use in the United States in December
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: Padcev 20mg Powder for Concentrate for Solution for Infusion, Padcev 30mg Powder for Concentrate for Solution for InfusionBasiliximab
go.drugbank.com/drugs/DB00074ApprovedInvestigationalIt is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell line genetically engineered to express plasmids containing the human heavy and light chain constant region genes … and mouse heavy and light chain variable region genes encoding the RFT5 antibody that binds selectively to the IL-2R alpha.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: SIMULECT LYOPHILISATE FOR INJECTION 20MG PER VIALEconazole
go.drugbank.com/drugs/DB01127ApprovedIt is used topically in dermatomycoses also orally and parenterally.
Categories: Imidazole and Triazole Derivatives, Genito Urinary System and Sex HormonesProducts: GYNO-PEVARYL DEPOT 150MG, Ecostatin Vaginal Ovule 150mgSplicing factor, proline- and glutamine-rich
go.drugbank.com/bio_entities/BE0008965TargetHumansDuring splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release … from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion.
Polypeptides: Splicing factor, proline- and glutamine-richPropantheline
go.drugbank.com/drugs/DB00782ApprovedA muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Categories: Alimentary Tract and Metabolism, propantheline and psycholepticsProducts: Propanthel Tab 15mg, Pro-banthine Tablets 15mgAceclofenac
go.drugbank.com/drugs/DB06736ApprovedAceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. … stiffness, crepitus, and local inflammation [A19666].
Categories: Acetic Acid Derivatives and Related Substances, Antiinflammatory and Antirheumatic ProductsProducts: AIRTAL FILM COATED TABLETS 100mg, Airtal 100mg Film-coated TabletTrovafloxacin
go.drugbank.com/drugs/DB00685ApprovedWithdrawnIt exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. … Due to its hepatotoxic potential, trovafloxacin was withdrawn from the market.
Products: Trovan Tablets 100mgTrastuzumab deruxtecan
go.drugbank.com/drugs/DB14962ApprovedInvestigational[L10842] It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from other members of its class. … [A188988] Trastuzumab deruxtecan was developed by Daiichi Sankyo in collaboration with AstraZeneca and was first approved by the FDA in 2019.[L10842]
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: ENHERTU POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/VIALCocaine- and amphetamine-regulated transcript protein
go.drugbank.com/bio_entities/BE0000867TargetHumansSatiety factor closely associated with the actions of leptin and neuropeptide Y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced … It promotes neuronal development and survival in vitro
Polypeptides: Cocaine- and amphetamine-regulated transcript protein