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Displaying results 1221 - 1230 of 10000 in total
  1. Pathway

    Gi Serotonergic Smooth Muscle Relaxation

    smpdb.ca/view/SMP0126986
    Physiological

    Although numerous GPCRs have the ability to couple to more than one heterotrimeric G protein, a given GPCR is typically classified based on the G protein subfamily (e.g., Gs, Gi/o, or Gq/11) it preferentially activates. Activation of the...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
  2. Pathway

    Metoclopramide Serotonergic Smooth Muscle Contraction

    smpdb.ca/view/SMP0127039
    Drug action

    Metoclopramide is a dopamine receptor antagonist and has been approved by the FDA to treat nausea and vomiting in patients with gastroesophageal reflux disease or diabetic gastroparesis by increasing gastric motility.. Metoclopramide wor...

    Drugs: ATP · Metoclopramide · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate +1 more
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  3. Pathway

    Prucalopride Action Pathway

    smpdb.ca/view/SMP0127044
    Drug action

    Prucalopride acts as a selective stimulator of the 5-HT4 receptors while having no interaction with hERG channel or 5-HT1 receptors which reduces significantly the cardiovascular risk found in other similar drugs. 5-HT4 receptors can be ...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid +1 more
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  4. Drug

    Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated)

    go.drugbank.com/drugs/DB10793
    ApprovedInvestigational

    A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. … Inactivated vaccines contain a virus particle that has been grown in media and then subsequently killed, or inactivated, through exposure to heat or chemicals such as formaldehyde 3.

    Mixtures: INFLUVAC S TETRA, INFLUVAC S TETRACategories: Inactivated Influenza B Virus Vaccine
  5. Drug

    Rutin

    go.drugbank.com/drugs/DB01698
    ApprovedInvestigational

    A flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc. It has been used therapeutically to decrease capillary fragility.

    Mixtures: KORDEL`S C TIME ACID FREE C 1000MG TABLET, KORDEL`S NUTRITIME TABLETCategories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 Inducers
  6. Drug

    Dactylis glomerata pollen

    go.drugbank.com/drugs/DB10379
    Approved

    Dactylis glomerata pollen is the pollen of the Dactylis glomerata plant. Dactylis glomerata pollen is mainly used in allergenic testing.

    Mixtures: GRASS MIX Number 4-S, GRASS MIX Number 4-S
  7. Drug

    Trimebutine

    go.drugbank.com/drugs/DB09089
    ApprovedInvestigational

    Trimebutine is not a FDA-approved drug, but it is available in Canada and several other international countries. … It is used to restore normal bowel function and is commonly present in pharmaceutical mixtures as trimebutine maleate salt form.

    Synonyms: 2-Dimethylamino-2-phenylbutyl 3,4,5-trimethoxybenzoatInternational brands: Newbutin SR
  8. Drug

    Medicago sativa pollen

    go.drugbank.com/drugs/DB10454
    Approved

    Medicago sativa pollen is the pollen of the Medicago sativa plant. Medicago sativa pollen is mainly used in allergenic testing.

    Mixtures: KORDEL`S NUTRITIME TABLET
  9. Drug

    Sulpiride

    go.drugbank.com/drugs/DB00391
    ApprovedWithdrawn

    [A229683] Sulpiride is not approved by the FDA, Health Canada, or the EMA; though it is approved in individual European countries.[L24679] … [A229538] Clinical studies show a greater effect on treating the negative symptoms of schizophrenia rather than positive symptoms at low doses, though the effects are more equal at higher doses.

    Mixtures: NEUPAX DUO-SCategories: MATE 1 Substrates, MATE 2 Substrates
  10. Drug

    Baloxavir marboxil

    go.drugbank.com/drugs/DB13997
    ApprovedInvestigational

    [L4779] It was also approved by the European Commission on January 7, 2021.[L45241] … Baloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: XOFLUZA 20 MG FİLM KAPLI TABLET, 2 ADET, XOFLUZA 20 MG FİLM KAPLI TABLET, 4 ADET