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Displaying results 1231 - 1240 of 10000 in total
  1. Target

    Scavenger receptor cysteine-rich type 1 protein M130

    go.drugbank.com/bio_entities/BE0003375
    TargetHumans

    Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage.

    Polypeptides: Scavenger receptor cysteine-rich type 1 protein M130Synonyms: Hemoglobin scavenger receptor
  2. Target

    Putative high affinity immunoglobulin gamma Fc receptor IB

    go.drugbank.com/bio_entities/BE0004684
    TargetHumans

    May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response

    Polypeptides: Putative high affinity immunoglobulin gamma Fc receptor IBSynonyms: IgG Fc receptor IB, Fc gamma receptor IB pseudogene
  3. Target

    Nuclear receptor subfamily 4 group A member 3

    go.drugbank.com/bio_entities/BE0008998
    TargetHumans

    In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation (By similarity). … Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (By similarity).

    Polypeptides: Nuclear receptor subfamily 4 group A member 3Synonyms: Nuclear hormone receptor NOR-1, Neuron-derived orphan receptor 1
  4. Target

    Nuclear receptor subfamily 1 group D member 2

    go.drugbank.com/bio_entities/BE0009348
    TargetHumans

    Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). … Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression.

    Polypeptides: Nuclear receptor subfamily 1 group D member 2Synonyms: Rev-erb alpha-related receptor, Orphan nuclear hormone receptor BD73
  5. Target

    Leukocyte immunoglobulin-like receptor subfamily A member 4

    go.drugbank.com/bio_entities/BE0013620
    TargetHumans

    Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic ...

    Polypeptides: Leukocyte immunoglobulin-like receptor subfamily A member 4
  6. Target

    Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

    go.drugbank.com/bio_entities/BE0020703
    TargetHumans

    Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:10713165, PubMed:20005308, PubMed:21376232).

    Polypeptides: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
  7. Drug

    Talniflumate

    go.drugbank.com/drugs/DB09295
    Investigational

    research has now been discontinued [L1402, L1405]. … Talniflumate has been approved for approximately 20 years in Argentina other countries (excluding the United States, Europe, and Japan) [L1405].

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  8. Drug

    Risdiplam

    go.drugbank.com/drugs/DB15305
    ApprovedInvestigational

    [L12615] It increases systemic SMN protein concentrations by improving the efficiency of _SMN2_ gene transcription. … This mechanism of action is similar to its predecessor [nusinersen], the biggest difference being their route of administration: nusinersen requires intrathecal administration, as does the one-time gene

    Categories: MATE 1 Inhibitors, MATE 2 Inhibitors
  9. Drug

    Astemizole

    go.drugbank.com/drugs/DB00637
    ApprovedWithdrawn

    Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms.

    Synonyms: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole, 1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazoleCategories: Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
  10. Drug

    Light green SF yellowish

    go.drugbank.com/drugs/DB11183
    Approved

    Light green SF yellowish is a green triarylmethane dye that is used in the preparation of the staining solution which is widely used as a counterstain. … Light green SF yellowish is also available as sterile strips used as a diagnostic agent when superficial corneal or conjunctival tissue change is suspected.

    Synonyms: A F Green No.2, Green No. 2Categories: P-glycoprotein inhibitors