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Proteasome activator complex subunit 1
go.drugbank.com/bio_entities/BE0008976TargetHumansThe PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome
Synonyms: IGUP I-5111, Interferon gamma up-regulated I-5111 proteinZolmitriptan
go.drugbank.com/drugs/DB00315ApprovedInvestigational[A462, L12978] [Sumatriptan] was the first triptan to be developed, but had poor oral bioavailability and lipophilicity. … [A193797] Zolmitriptan was first approved by the FDA for sale by Zeneca Pharmaceuticals under the trade name Zomig® on November 25, 1997.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Cytochrome P-450 SubstratesSynonyms: (S)-4-({3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}methyl)-1,3-oxazolidin-2-one, 4-[[3-(2-dimethylaminoethyl)-1H-indol-5-yl]methyl]oxazolidin-2-oneSevoflurane
go.drugbank.com/drugs/DB01236ApprovedInvestigationalVet approved[A249885] Sevoflurane is three times more potent than [desflurane], but has lower potency compared to [halothane] and [isoflurane]. … [A249910] Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.[A249885]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 SubstratesSynonyms: 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propaneDaprodustat
go.drugbank.com/drugs/DB11682ApprovedInvestigationalanemia of CKD but not for non-dialysis patients with anemia of CKD. … [L43857] On February 1, 2023, daprodustat was fully approved by the FDA as the first oral treatment for anemia caused by chronic kidney disease in patients on dialysis.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: Glycine, N-((1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl)-Melphalan
go.drugbank.com/drugs/DB01042ApprovedInvestigational[L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard. … [L47890] It is also used to treat uveal melanoma with unresectable hepatic metastases.[L47895]
Synonyms: p-N,N-bis(2-chloroethyl)amino-L-phenylalanine, p-N-Bis(2-chloroethyl)amino-L-phenylalanineProducts: ALKERAN® 2 MG TABLETAS, ALKERAN® INYECTABLEPheniramine
go.drugbank.com/drugs/DB01620ApprovedPheniramine's use as an anti-allergy medication has largely been supplanted by second-generation antihistamines such as [cetirizine] and [loratadine]. … Pheniramine is a first-generation antihistamine in the alkylamine class, similar to [brompheniramine] and [chlorpheniramine].
Mixtures: Bronchodex D Cap, Cold Decongestant Long Acting CapCategories: Heterocyclic Compounds, 1-RingcAMP-dependent protein kinase (Protein kinase A)
go.drugbank.com/bio_entities/BE0010127TargetHumans(NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP (PubMed:15642694, PubMed:20356841). … by an increased rate of Ca(2+) release and propagation velocity of spontaneous Ca(2+) waves, despite reduced wave amplitude and resting cytosolic Ca(2+) (PubMed:17693412).
Polypeptides: cAMP-dependent protein kinase type I-alpha regulatory subunit, cAMP-dependent protein kinase type I-beta regulatory subunitNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
go.drugbank.com/bio_entities/BE0000512TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. … Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Synonyms: Complex I-B18Fatty acid-binding protein, intestinal
go.drugbank.com/bio_entities/BE0003591CarrierTargetHumansBinds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids.
Synonyms: I-FABP