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Displaying results 1251 - 1260 of 10000 in total
  1. Drug

    Linaclotide

    go.drugbank.com/drugs/DB08890
    ApprovedInvestigational

    Linaclotide is a synthetic 14-amino acid cyclic peptide [A260271] and first-in-class guanylate cyclase-C (G-CC) agonist. … [A260276] It is also a homolog of a heat-stable enterotoxin derived from _Escherichia coli_, the first natural ligand that activates GC-C.

    Categories: Guanylate Cyclase-C Agonist, Guanylyl Cyclase C AgonistsSynonyms: -GLUTAMYL-L-TYROSYL-L-CYSTEINYL-L-CYSTEINYL-L-ASPARAGINYL-L-PROLYL-L-ALANYL-L-CYSTEINYL-L-THREONYLGLYCYL-L-CYSTEINYL-, CYCLIC (1->6),(2->10),(5->13)-TRIS(DISULFIDE), L-TYROSINE, L-CYSTEINYL-L-CYSTEINYL-L-.ALPHA.
  2. Drug

    Flax seed

    go.drugbank.com/drugs/DB10708
    Approved

    Flax seed allergenic extract is used in allergenic testing.

    Mixtures: Nature"s Gift CoQ10 Plus
  3. Pathway

    Gi Serotonergic Smooth Muscle Relaxation

    smpdb.ca/view/SMP0126986
    Physiological

    Although numerous GPCRs have the ability to couple to more than one heterotrimeric G protein, a given GPCR is typically classified based on the G protein subfamily (e.g., Gs, Gi/o, or Gq/11) it preferentially activates. Activation of the...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
  4. Pathway

    Metoclopramide Serotonergic Smooth Muscle Contraction

    smpdb.ca/view/SMP0127039
    Drug action

    Metoclopramide is a dopamine receptor antagonist and has been approved by the FDA to treat nausea and vomiting in patients with gastroesophageal reflux disease or diabetic gastroparesis by increasing gastric motility.. Metoclopramide wor...

    Drugs: ATP · Metoclopramide · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate +1 more
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  5. Pathway

    Prucalopride Action Pathway

    smpdb.ca/view/SMP0127044
    Drug action

    Prucalopride acts as a selective stimulator of the 5-HT4 receptors while having no interaction with hERG channel or 5-HT1 receptors which reduces significantly the cardiovascular risk found in other similar drugs. 5-HT4 receptors can be ...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid +1 more
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  6. Drug

    Rutin

    go.drugbank.com/drugs/DB01698
    ApprovedInvestigational

    A flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc. It has been used therapeutically to decrease capillary fragility.

    Mixtures: KORDEL`S C TIME ACID FREE C 1000MG TABLET, KORDEL`S NUTRITIME TABLETCategories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 Inducers
  7. Drug

    Trimebutine

    go.drugbank.com/drugs/DB09089
    ApprovedInvestigational

    Trimebutine is not a FDA-approved drug, but it is available in Canada and several other international countries. … It is used to restore normal bowel function and is commonly present in pharmaceutical mixtures as trimebutine maleate salt form.

    Synonyms: 2-Dimethylamino-2-phenylbutyl 3,4,5-trimethoxybenzoatInternational brands: Newbutin SR
  8. Drug

    Sodium acetate

    go.drugbank.com/drugs/DB09395
    ApprovedInvestigational

    Sodium Acetate is chemically designated CH3COONa, a hygroscopic powder very soluble in water. … Medically, sodium acetate is important component as an electrolyte replenisher when given intravenously. It is mainly indicated to correct sodium levels in hyponatremic patients.

    Mixtures: B S S STERILE IRRIGATING SOLUTION, Isolyte SSynonyms: Acetic acid, sodium salt (1:1)
  9. Drug

    Sulpiride

    go.drugbank.com/drugs/DB00391
    ApprovedWithdrawn

    [A229683] Sulpiride is not approved by the FDA, Health Canada, or the EMA; though it is approved in individual European countries.[L24679] … [A229538] Clinical studies show a greater effect on treating the negative symptoms of schizophrenia rather than positive symptoms at low doses, though the effects are more equal at higher doses.

    Mixtures: NEUPAX DUO-SCategories: MATE 1 Substrates, MATE 2 Substrates
  10. Drug

    Medicago sativa pollen

    go.drugbank.com/drugs/DB10454
    Approved

    Medicago sativa pollen is the pollen of the Medicago sativa plant. Medicago sativa pollen is mainly used in allergenic testing.

    Mixtures: KORDEL`S NUTRITIME TABLET