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Omadacycline
go.drugbank.com/drugs/DB12455ApprovedInvestigationalinfections caused by gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), and by gram-negative, atypical and anaerobic bacteria, including those resistant to currently available … classes of antibiotics and known to cause diseases such as pneumonias, urinary tract infections, skin diseases and blood-borne infections in both the hospital and community settings.
Ketorolac
go.drugbank.com/drugs/DB00465ApprovedInvestigational[L6520] Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.[L6511]
Mixtures: MAVIDOL TR, MAVIDOL TRProducts: KENDOLIT TTolazamide
go.drugbank.com/drugs/DB00839ApprovedA sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Methylene blue
go.drugbank.com/drugs/DB09241ApprovedInvestigationalHistorically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs entered the market. … clinical trials to be an inhibitor of Tau protein aggregation.
Mixtures: Urimar-T, Urimar-TCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeNuvaxovid
go.drugbank.com/drugs/DB15810ApprovedInvestigational[A243789, A243794, A243799] The European Commission granted Novavax conditional marketing authorization for nuvaxovid for active immunization to prevent COVID-19 caused by SARS-CoV-2 on December 20, … [L40548,L40553] On July 13, 2022, nuvaxovid was granted an emergency use authorization by the FDA for the prevention of COVID-19 in adults, which was expanded to include patients ≥12 years of age in August
Oritavancin
go.drugbank.com/drugs/DB04911ApprovedInvestigational[L12858] Oritavancin was initially approved by the FDA in 2014 and formulated to combat susceptible gram-positive bacteria that cause skin and skin structure infections. … It boasts the option of single-dose administration and has been proven as non-inferior to a full course of [vancomycin] therapy.
Pegloticase
go.drugbank.com/drugs/DB09208ApprovedInvestigational[L42425] Pegloticase was approved by the FDA in 2014, and in 2022, the drug label included the co-administration of pegloticase and methotrexate.[L42425] … [L42425] Pegloticase has a similar activity to rasburicase, an enzyme that metabolizes uric acid to allantoin.
Diroximel fumarate
go.drugbank.com/drugs/DB14783ApprovedInvestigationalThis drug is bioequivalent to [Dimethyl fumarate][A187544,L9626](initially manufactured in 2013), but is less likely to cause gastrointestinal side effects, owing to its unique chemical structure. … Diroximel fumarate was formulated by Alkermes in collaboration with Biogen, and was approved by the FDA in October 2019[L9626] and by the EMA in November 2021.[L39225]
Raltegravir
go.drugbank.com/drugs/DB06817ApprovedInvestigationalRaltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. … Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval.