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Displaying results 1271 - 1280 of 10000 in total
  1. Target

    Vitamin D3 receptor

    go.drugbank.com/bio_entities/BE0000779
    TargetHumans

    Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:10678179, PubMed:15728261, PubMed:16913708, PubMed:28698609, PubMed:37478846). Enters the nucleus upon vitamin D3 b...

    Synonyms: Nuclear receptor subfamily 1 group I member 1
  2. Drug

    Tizanidine

    go.drugbank.com/drugs/DB00697
    ApprovedInvestigational

    It may also be caused by musculoskeletal injury [A177583]. Regardless of the cause, muscle spasticity can be an extremely painful and debilitating condition. … Initially approved by the FDA in 1996, tizanidine is an Alpha-2 adrenergic receptor agonist reducing spasticity by the presynaptic inhibition of excitatory neurotransmitters that cause firing of neurons

    Mixtures: MYOS -NOR F TABLETAS, ALGI - B® TABLETASCategories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 Substrates
  3. Drug

    Benzonatate

    go.drugbank.com/drugs/DB00868
    Approved

    [A5790] Currently, benzonatate is the only non-narcotic antitussive available as a prescription drug. … [A189519] It works to reduce the activity of cough reflex by desensitizing the tissues of the lungs and pleura involved in the cough reflex.

    Synonyms: nonaethyleneglycol monomethyl ether p-n-butylaminobenzoate, p-butylaminobenzoic acid ω-O-methylnonaethyleneglycol esterCategories: Non-narcotic Antitussive
  4. Drug

    Valsartan

    go.drugbank.com/drugs/DB00177
    ApprovedInvestigational

    angiotensin I to angiotensin II through inhibition of the ACE enzyme. … ARBs have been shown to have a protective effect on the heart by improving cardiac function, reducing afterload, increasing cardiac output and preventing ventricular hypertrophy and remodelling.

    Mixtures: VALSARTAN HCT MK 80 MG/12.5 MG COMPRIMIDOS RECUBIERTOS, EXFORGE® 5/80 MG COMPRIMIDOS CON CUBIERTA PELICULARCategories: Agents Acting on the Renin-Angiotensin System, Angiotensin II Type 1 Receptor Blockers
  5. Drug

    Magnesium acetate tetrahydrate

    go.drugbank.com/drugs/DB09409
    ApprovedWithdrawn

    Magnesium acetate tetrahydrate can be used as an electrolyte supplementation or a reagent in molecular biology experiments. … Magnesium is an essential element and second most abundant cation in the body that plays a key role in maintaining normal cellular function such as production of ATP and efficient enzyme activity.

    Mixtures: ELETTROLITICA BILANCIATA DI MANTENIMENTO CON GLUCOSIO S.A.L.F., ELETTROLITICA BILANCIATA DI MANTENIMENTO CON GLUCOSIO BIOINDUSTRIA L.I.M.
  6. Drug

    Durlobactam

    go.drugbank.com/drugs/DB16704
    ApprovedInvestigational

    Durlobactam is a diazabicyclooctane non-beta-lactam, beta-lactamase inhibitor. It is typically given in combination with [sulbactam] to protect it from degradation by certain serine-beta-lactamases. … [A263306] It is used to treat hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP), caused by susceptible isolates of _Acinetobacter baumannii-calcoaceticus_

    Synonyms: (2S,5R)-2-CARBAMOYL-3-METHYL-7-OXO-1,6-DIAZABICYCLO(3.2.1)OCT-3-EN-6-YL SULFATE, SULFURIC ACID, MONO((2S,5R)-2-(AMINOCARBONYL)-3-METHYL-7-OXO-1,6-DIAZABICYCLO(3.2.1)OCT-3-EN-6-YL) ESTER
  7. Drug

    Viloxazine

    go.drugbank.com/drugs/DB09185
    ApprovedInvestigationalWithdrawn

    It was first approved in the UK in 1974; however, the immediate-release formulation was discontinued due to business reasons unrelated to drug safety and efficacy. … In April 2021, an extended-release formulation of viloxazine under the brand name QELBREE was approved by the FDA for the treatment of attention deficit hyperactivity disorder (ADHD).[A247985]

    Categories: MATE 1 Inhibitors, Cytochrome P-450 SubstratesSynonyms: 2-((2-Ethoxyphenoxy)methyl)morpholine
  8. Drug

    Antipyrine

    go.drugbank.com/drugs/DB01435
    Approved

    An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.

    Mixtures: Oti Cal, CALZAS®Categories: Non COX-2 selective NSAIDS, Anti-Inflammatory Agents, Non-Steroidal (Non-Selective)
  9. Drug

    Levoketoconazole

    go.drugbank.com/drugs/DB05667
    Approved

    [A244083, A29319, L39573] Levoketoconazole was approved by the FDA on December 30, 2021, and is currently marketed under the registered trademark RECORLEV by Xeris Pharmaceuticals, Inc.[L39563] … Cushing's syndrome (CS) is underpinned by chronic hypercortisolism leading to multisystem morbidity, including effects on the cardiovascular and endocrine systems, metabolic syndrome with accompanying

    Categories: MATE 1 Inhibitors, P-glycoprotein inhibitors
  10. Target

    Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

    go.drugbank.com/bio_entities/BE0000457
    TargetHumans

    Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine … Also able to hydrolyze 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production (PubMed:25344812). 2',3'-cGAMP degradation takes place in

    Synonyms: Alkaline phosphodiesterase I, Phosphodiesterase I/nucleotide pyrophosphatase 1