Magnesium acetate tetrahydrate

Identification

Summary

Magnesium acetate tetrahydrate is an ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.

Generic Name

DrugBank Accession Number

DB09409

Background

Magnesium acetate tetrahydrate is a hydrated form of anhydrous magnesium acetate salt with the chemical formula of Mg(CH3COO)2 • 4H2O. As a salt form of magnesium, magnesium acetate is one of the bioavailable forms of magnesium and forms a very water soluble compound. Magnesium is an essential element and second most abundant cation in the body that plays a key role in maintaining normal cellular function such as production of ATP and efficient enzyme activity. Magnesium acetate tetrahydrate can be used as an electrolyte supplementation or a reagent in molecular biology experiments.

Type

Small Molecule

Groups

Approved

Structure

Similar Structures

Weight: Average: 214.453
Monoisotopic: 214.05390911
Chemical Formula: C₄H₁₄MgO₈

Synonyms

Acetic acid, magnesium salt, tetrahydrate
Magnesium diacetate tetrahydrate

Pharmacology

Indication

Used as magnesium salf-containing laxatives to prevent constipation. It can bring synergistic effect to restore normal bowel function when using in combination with aluminum salts that induce bowel retention ⁸. Magnesium acetate tetrahydrate is used as a source of water and electrolytes when combined with dextrose and other salts to form intravenous infusions. This injection can be used for patients with carbohydrate or magnesium deficiency, insulin hypoglycemia, constipation or hypertension during pregnancy.

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Associated Therapies

Contraindications & Blackbox Warnings

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Pharmacodynamics

Magnesium is an essential cofactor for many enzymatic reactions such as protein synthesis and ATP production. It also participates in adenylyl cyclase pathway and tyrosine kinase signalling pathways. Magnesium may also play a role in regulating glucose metabolism. It serves as an essential cation for a number of biochemical processes involved in nerve signaling, bone mineralization and muscle contractions.

Mechanism of action

Magnesium ions electrostatically stabilize the adenylyl cyclase complex and enhance its catalytic actions and production of cAMP. They also regulate the level of phosphorylation in various pathways by formation of transition state of phosphoryl transfer reaction by protein kinases and stabilize ATP binding to protein kinases via electrostatic interactions ⁷. Many metabolic enzymes involved in glycolysis and Krebs cycle are magnesium-dependent. Magnesium-containing laxatives cause diarrhea through water retention and increased fecal mass that stimulates peristalsis. When used as an electrolyte supplementation, magnesium acetate tetrahydrate induces diuresis and metabolic alkalinizing effect. Magnesium ions enhance reactivity of arteries to vasoconstrictors, promotes vasoconstriction, and increases peripheral resistance, leading to increased blood pressure ⁴ through potential competition with calcium ions in the vascular system. Magnesium ions also regulate other ions entering and exiting the cell membrane by acting as a ligand in N-methyl-D-aspartate receptor.

Target	Actions	Organism
UGlutamate (NMDA) receptor	ligand	Humans

Absorption

Intestinal absorption is achieved mainly through passive diffusion.

Volume of distribution

Magnesium ions display approximate volume of distribution of 0.2 to 0.4 L/kg

Protein binding

Protein binding of magnesium ions is about 30%

Metabolism

Not Available

Route of elimination

Mainly renal exctretion, where up to 97% of magnesium may be excreted renally during hypermagnesemia.

Half-life

Elimination half-life has been reported to be 27.7 hours following an overdose of 400mEq magnesium in an adult.

Clearance

Not Available

Adverse Effects

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Toxicity

Predicted oral LD50 value is >2000mg/kg. In case of mild to moderate toxicity, it may cause irritation in case of skin or eye contact,and nausea or vomiting from ingestion and inhalation. In overdose, magnesium impairs neuromuscular transmission, manifested as weakness and hyporeflexia. Early manifestations of severe toxicity are lethargy, hyporeflexia, followed by weakness, paralysis, hypotension, ECG changes (prolonged PR and QRS intervals), CNS depression, seizures, and respiratory depression.

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Acetazolamide	The risk or severity of dehydration can be increased when Acetazolamide is combined with Magnesium acetate tetrahydrate.
Alfentanil	The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Alfentanil.
Amiloride	The risk or severity of dehydration can be increased when Amiloride is combined with Magnesium acetate tetrahydrate.
Amiodarone	The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Amiodarone.
Amlodipine	The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Amlodipine.
Atracurium	The therapeutic efficacy of Atracurium can be increased when used in combination with Magnesium acetate tetrahydrate.
Atracurium besylate	The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Magnesium acetate tetrahydrate.
Bendroflumethiazide	The risk or severity of dehydration can be increased when Bendroflumethiazide is combined with Magnesium acetate tetrahydrate.
Benzhydrocodone	The therapeutic efficacy of Magnesium acetate tetrahydrate can be decreased when used in combination with Benzhydrocodone.
Benzthiazide	The risk or severity of dehydration can be increased when Benzthiazide is combined with Magnesium acetate tetrahydrate.

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Food Interactions

No interactions found.

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Active Moieties

Name	Kind	UNII	CAS	InChI Key
Magnesium cation	ionic	T6V3LHY838	22537-22-0	JLVVSXFLKOJNIY-UHFFFAOYSA-N

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Numeta G 13 % E Emulsion zur Infusion	Magnesium acetate tetrahydrate (0.63 g) + Alanine (4.66 g) + Arginine (4.89 g) + Aspartic acid (3.5 g) + Calcium chloride dihydrate (3.45 g) + Cysteine (1.1 g) + D-glucose monohydrate (550 g) + Glutamic acid (5.83 g) + Glycine (2.33 g) + Histidine (2.21 g) + Isoleucine (3.9 g) + Leucine (5.83 g) + Lysine monohydrate (6.41 g) + Methionine (1.4 g) + Olive oil (6 g) + Ornithine hydrochloride (1.45 g) + Phenylalanine (2.45 g) + Potassium acetate (3.83 g) + Proline (1.75 g) + Serine (2.33 g) + Sodium glycerophosphate hydrate (6.15 g) + Soybean oil (1.5 g) + Taurine (0.35 g) + Threonine (2.16 g) + Tryptophan (1.17 g) + Tyrosine (0.45 g) + Valine (4.43 g)	Injection, emulsion	Parenteral	Baxter Healthcare Gmb H	2016-05-11	Not applicable
Numeta G 16 % E Emulsion zur Infusion	Magnesium acetate tetrahydrate (0.33 g) + Alanine (1.03 g) + Arginine (1.08 g) + Aspartic acid (0.77 g) + Calcium chloride dihydrate (0.46 g) + Cysteine (0.24 g) + D-glucose monohydrate (85.25 g) + Glutamic acid (1.29 g) + Glycine (0.51 g) + Histidine (0.49 g) + Isoleucine (0.86 g) + Leucine (1.29 g) + Lysine monohydrate (1.59 g) + Methionine (0.31 g) + Olive oil (12.4 g) + Ornithine hydrochloride (0.41 g) + Phenylalanine (0.54 g) + Potassium acetate (1.12 g) + Proline (0.39 g) + Serine (0.51 g) + Sodium chloride (0.3 g) + Sodium glycerophosphate hydrate (0.98 g) + Soybean oil (3.1 g) + Taurine (0.08 g) + Threonine (0.48 g) + Tryptophan (0.26 g) + Tyrosine (0.1 g) + Valine (0.98 g)	Injection, emulsion	Intravenous	Baxter Healthcare Gmb H	2011-03-17	Not applicable
Numeta G 19 % E Emulsion zur Infusion	Magnesium acetate tetrahydrate (0.55 g) + Alanine (1.83 g) + Arginine (1.92 g) + Aspartic acid (1.37 g) + Calcium chloride dihydrate (0.56 g) + Cysteine (0.43 g) + D-glucose monohydrate (210.65 g) + Glutamic acid (2.29 g) + Glycine (0.91 g) + Histidine (0.87 g) + Isoleucine (1.53 g) + Leucine (2.29 g) + Lysine (2.82 g) + Methionine (0.55 g) + Olive oil (22.48 g) + Ornithine hydrochloride (0.73 g) + Phenylalanine (0.96 g) + Potassium acetate (3.14 g) + Proline (0.69 g) + Serine (0.91 g) + Sodium chloride (1.79 g) + Sodium glycerophosphate hydrate (2.21 g) + Soybean oil (5.62 g) + Taurine (0.14 g) + Threonine (0.85 g) + Tryptophan (0.46 g) + Tyrosine (0.18 g) + Valine (1.74 g)	Injection, emulsion	Intravenous	Baxter Healthcare Gmb H	2011-03-17	Not applicable
NUMETA PED G 19 % E INFÜZYON IÇIN EMÜLSIYON, 1000 ML	Magnesium acetate tetrahydrate (0.55 g) + Alanine (1.83 g) + Arginine (1.92 g) + Aspartic acid (1.37 g) + Calcium chloride dihydrate (0.56 g) + Cysteine (0.43 g) + D-glucose monohydrate (210.65 g) + Glutamic acid (2.29 g) + Glycine (0.91 g) + Histidine (0.87 g) + Isoleucine (1.53 g) + Leucine (2.29 g) + Lysine (2.82 g) + Methionine (0.55 g) + Olive oil (22.48 g) + Ornithine hydrochloride (0.73 g) + Phenylalanine (0.96 g) + Potassium acetate (3.14 g) + Proline (0.69 g) + Serine (0.91 g) + Sodium chloride (1.79 g) + Sodium glycerophosphate hydrate (2.21 g) + Soybean oil (5.62 g) + Taurine (0.14 g) + Threonine (0.85 g) + Tryptophan (0.46 g) + Tyrosine (0.18 g) + Valine (1.74 g)	Emulsion	Intravenous	EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.	2020-08-14	Not applicable
NUMETA PED G16 % E İNFÜZYONLUK EMÜLSİYON, 500 ML	Magnesium acetate tetrahydrate (0.33 g) + Alanine (1.03 g) + Arginine (1.08 g) + Aspartic acid (0.77 g) + Calcium chloride dihydrate (0.46 g) + Cysteine (0.24 g) + D-glucose monohydrate (85.25 g) + Glutamic acid (1.29 g) + Glycine (0.51 g) + Histidine (0.49 g) + Isoleucine (0.86 g) + Leucine (1.29 g) + Lysine monohydrate (1.59 g) + Methionine (0.31 g) + Olive oil (12.4 g) + Ornithine hydrochloride (0.41 g) + Phenylalanine (0.54 g) + Potassium acetate (1.12 g) + Proline (0.39 g) + Serine (0.51 g) + Sodium chloride (0.3 g) + Sodium glycerophosphate hydrate (0.98 g) + Soybean oil (3.1 g) + Taurine (0.08 g) + Threonine (0.48 g) + Tryptophan (0.26 g) + Tyrosine (0.1 g) + Valine (0.98 g)	Injection	Intravenous	EİP ECZACIBAŞI İLAÇ PAZARLAMA A.Ş.	2020-08-14	2022-04-11
Nutriflex Lipid peri B. Braun, Emulsion zur Infusion	Magnesium acetate tetrahydrate (0.515 g/l) + Alanine (3.88 g/l) + Arginine (2.16 g/l) + Aspartic acid (1.2 g/l) + Calcium chloride dihydrate (0.353 g/l) + D-glucose monohydrate (70.4 g/l) + Glutamic acid (2.8 g/l) + Glycine (1.32 g/l) + Histidine monohydrochloride monohydrate (1.352 g/l) + Isoleucine (1.872 g/l) + Leucine (2.504 g/l) + Lysine hydrochloride (2.272 g/l) + Medium-chain triglycerides (20 g/l) + Methionine (1.568 g/l) + Phenylalanine (2.808 g/l) + Potassium acetate (2.354 g/l) + Proline (2.72 g/l) + Serine (2.4 g/l) + Sodium acetate trihydrate (0.435 g/l) + Sodium chloride (0.865 g/l) + Sodium hydroxide (0.64 g/l) + Sodium phosphate, monobasic, dihydrate (0.936 g/l) + Soybean oil (20 g/l) + Threonine (1.456 g/l) + Tryptophan (0.456 g/l) + Valine (2.08 g/l) + Zinc acetate dihydrate (5.28 mg/l)	Emulsion	Parenteral	B. Braun Melsungen Ag	2017-09-07	Not applicable
NUTRIFLEX LIPID PERI INFUZYONLUK IV EMULSIYON, 1250 ML	Magnesium acetate tetrahydrate (0.644 g) + Alanine (4.85 g) + Arginine (2.7 g) + Aspartic acid (1.5 g) + Calcium chloride dihydrate (0.441 g) + D-glucose monohydrate (88 g) + Glutamic acid (3.5 g) + Glycine (1.65 g) + Histidine (1.25 g) + Isoleucine (2.34 g) + Leucine (3.13 g) + Lysine hydrochloride (2.84 g) + Medium-chain triglycerides (25 g) + Methionine (1.96 g) + Phenylalanine (3.51 g) + Potassium acetate (2.943 g) + Proline (3.4 g) + Serine (3 g) + Sodium acetate trihydrate (0.544 g) + Sodium chloride (1.081 g) + Sodium hydroxide (0.8 g) + Sodium phosphate, monobasic, dihydrate (1.17 g) + Soybean oil (25 g) + Threonine (1.82 g) + Tryptophan (0.57 g) + Valine (2.6 g) + Zinc acetate dihydrate (6.625 mg)	Emulsion	Intravenous	B.BRAUN MEDİKAL DIŞ TİC. A.Ş.	2020-08-14	2018-10-12
NUTRIFLEX LIPID PERI INFUZYONLUK IV EMULSIYON, 1870 ML	Magnesium acetate tetrahydrate (0.966 g) + Acetate (60 mmol) + Alanine (7.28 g) + Arginine (4.05 g) + Aspartic acid (2.25 g) + Calcium (4.5 mmol) + Calcium chloride dihydrate (0.662 g) + Chlorine (72 mmol) + D-glucose (120 g) + Glutamic acid (5.25 g) + Glycine (2.48 g) + Histidine (1.88 g) + Isoleucine (3.51 g) + Leucine (4.7 g) + Lysine (3.39 g) + Magnesium (4.5 mmol) + Medium-chain triglycerides (37.5 g) + Methionine (2.94 g) + Phenylalanine (5.27 g) + Potassium (45 mmol) + Potassium acetate (4.415 g) + Proline (5.1 g) + Serine (4.5 g) + Sodium acetate trihydrate (0.816 g) + Sodium cation (75 mmol) + Sodium chloride (1.622 g) + Sodium hydroxide (1.2 g) + Sodium phosphate, monobasic, dihydrate (1.755 g) + Soybean oil (37.5 g) + Threonine (2.73 g) + Tryptophan (0.86 g) + Valine (3.9 g) + Zinc (0.045 mmol) + Zinc acetate dihydrate (9.938 mg)	Injection, emulsion	Intravenous	B.BRAUN MEDİKAL DIŞ TİC. A.Ş.	2020-08-14	2018-10-12
NUTRIFLEX LIPID PERI INFUZYONLUK IV EMULSIYON, 2500 ML	Magnesium acetate tetrahydrate (1.288 g) + Acetate (80 mmol) + Alanine (9.7 g) + Arginine (5.4 g) + Aspartic acid (3 g) + Calcium (6 mmol) + Calcium chloride dihydrate (0.882 g) + Chlorine (96 mmol) + D-glucose (160 g) + Glutamic acid (7 g) + Glycine (3.3 g) + Histidine (2.5 g) + Isoleucine (4.68 g) + Leucine (6.26 g) + Lysine (4.52 g) + Magnesium (6 mmol) + Medium-chain triglycerides (50 g) + Methionine (3.92 g) + Phenylalanine (7.02 g) + Potassium (60 mmol) + Potassium acetate (5.886 g) + Proline (6.8 g) + Serine (6 g) + Sodium acetate trihydrate (1.088 g) + Sodium cation (100 mmol) + Sodium chloride (2.162 g) + Sodium hydroxide (1.6 g) + Sodium phosphate, monobasic, dihydrate (2.34 g) + Soybean oil (50 g) + Threonine (3.64 g) + Tryptophan (1.14 g) + Valine (5.2 g) + Zinc (0.06 mmol) + Zinc acetate dihydrate (13.25 mg)	Injection, emulsion	Intravenous	B.BRAUN MEDİKAL DIŞ TİC. A.Ş.	2020-08-14	2018-10-12
Nutriflex Lipid plus B. Braun, Emulsion zur Infusion	Magnesium acetate tetrahydrate (0.686 g/l) + Alanine (4.656 g/l) + Arginine (2.592 g/l) + Aspartic acid (1.44 g/l) + Calcium chloride dihydrate (0.47 g/l) + D-glucose monohydrate (132 g/l) + Glutamic acid (3.368 g/l) + Glycine (1.584 g/l) + Histidine monohydrochloride monohydrate (1.624 g/l) + Isoleucine (2.256 g/l) + Leucine (3.008 g/l) + Lysine hydrochloride (2.728 g/l) + Medium-chain triglycerides (20 g/l) + Methionine (1.88 g/l) + Phenylalanine (3.368 g/l) + Potassium acetate (2.747 g/l) + Proline (3.264 g/l) + Serine (2.88 g/l) + Sodium acetate trihydrate (0.222 g/l) + Sodium chloride (0.402 g/l) + Sodium hydroxide (0.781 g/l) + Sodium phosphate, monobasic, dihydrate (1.872 g/l) + Soybean oil (20 g/l) + Threonine (1.744 g/l) + Tryptophan (0.544 g/l) + Valine (2.496 g/l) + Zinc acetate dihydrate (5.264 mg/l)	Emulsion	Parenteral	B. Braun Melsungen Ag	2017-09-07	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
PROCALAMINE SISE 1000 ML(SETLI)	Magnesium acetate tetrahydrate (0.054 g/100ml) + Alanine (0.21 g/100ml) + Arginine (0.29 g/100ml) + Calcium acetate monohydrate (0.026 g/100ml) + Cysteine hydrochloride (0.02 g/100ml) + Glycerin (3 g/100ml) + Glycine (0.42 g/100ml) + Histidine (0.085 g/100ml) + Isoleucine (0.21 g/100ml) + Leucine (0.27 g/100ml) + Lysine (0.22 g/100ml) + Methionine (0.16 g/100ml) + Phenylalanine (0.17 g/100ml) + Phosphoric acid (0.041 g/100ml) + Potassium chloride (0.149 g/100ml) + Potassium metabisulfite (0.05 g/100ml) + Proline (0.34 g/100ml) + Serine (0.18 g/100ml) + Sodium acetate trihydrate (0.204 g/100ml) + Sodium chloride (0.117 g/100ml) + Threonine (0.12 g/100ml) + Tryptophan (0.046 g/100ml) + Valine (0.2 g/100ml)	Solution	Parenteral	ECZACIBAŞI-BAXTER HASTANE ÜRÜNLERİ SAN.VE TİC. A.Ş.	2020-08-14	Not applicable
PROCALAMINE SISE 500 ML(SETLI)	Magnesium acetate tetrahydrate (0.054 g/100ml) + Alanine (0.21 g/100ml) + Arginine (0.29 g/100ml) + Calcium acetate monohydrate (0.026 g/100ml) + Cysteine hydrochloride (0.02 g/100ml) + Glycerin (3 g/100ml) + Glycine (0.42 g/100ml) + Histidine (0.085 g/100ml) + Isoleucine (0.21 g/100ml) + Leucine (0.27 g/100ml) + Lysine (0.22 g/100ml) + Methionine (0.16 g/100ml) + Phenylalanine (0.17 g/100ml) + Phosphoric acid (0.041 g/100ml) + Potassium chloride (0.149 g/100ml) + Potassium metabisulfite (0.05 g/100ml) + Proline (0.34 g/100ml) + Serine (0.18 g/100ml) + Sodium acetate trihydrate (0.204 g/100ml) + Sodium chloride (0.117 g/100ml) + Threonine (0.12 g/100ml) + Tryptophan (0.046 g/100ml) + Valine (0.2 g/100ml)	Solution	Parenteral	ECZACIBAŞI-BAXTER HASTANE ÜRÜNLERİ SAN.VE TİC. A.Ş.	2020-08-14	Not applicable
PROCALAMINE SISE 500 ML(SETSIZ)	Magnesium acetate tetrahydrate (0.054 g/100ml) + Alanine (0.21 g/100ml) + Arginine (0.29 g/100ml) + Calcium acetate monohydrate (0.026 g/100ml) + Cysteine hydrochloride (0.02 g/100ml) + Glycerin (3 g/100ml) + Glycine (0.42 g/100ml) + Histidine (0.085 g/100ml) + Isoleucine (0.21 g/100ml) + Leucine (0.27 g/100ml) + Lysine (0.22 g/100ml) + Methionine (0.16 g/100ml) + Phenylalanine (0.17 g/100ml) + Phosphoric acid (0.041 g/100ml) + Potassium chloride (0.149 g/100ml) + Potassium metabisulfite (0.05 g/100ml) + Proline (0.34 g/100ml) + Serine (0.18 g/100ml) + Sodium acetate trihydrate (0.204 g/100ml) + Sodium chloride (0.117 g/100ml) + Threonine (0.12 g/100ml) + Tryptophan (0.046 g/100ml) + Valine (0.2 g/100ml)	Solution	Parenteral	ECZACIBAŞI-BAXTER HASTANE ÜRÜNLERİ SAN.VE TİC. A.Ş.	2020-08-14	Not applicable

Chemical Identifiers

UNII: I01G0EJC3B
CAS number: 16674-78-5
InChI Key: XKPKPGCRSHFTKM-UHFFFAOYSA-L
InChI: InChI=1S/2C2H4O2.Mg.4H2O/c2*1-2(3)4;;;;;/h2*1H3,(H,3,4);;4*1H2/q;;+2;;;;/p-2
IUPAC Name: magnesium(2+) ion diacetate tetrahydrate
SMILES: O.O.O.O.[Mg++].CC([O-])=O.CC([O-])=O

References

General References

Guerrera MP, Volpe SL, Mao JJ: Therapeutic uses of magnesium. Am Fam Physician. 2009 Jul 15;80(2):157-62. [Article]
Zimmermann G, Zhou D, Taussig R: Mutations uncover a role for two magnesium ions in the catalytic mechanism of adenylyl cyclase. J Biol Chem. 1998 Jul 31;273(31):19650-5. [Article]
Rodriguez-Moran M, Guerrero-Romero F: Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care. 2003 Apr;26(4):1147-52. [Article]
Jin K, Kim TH, Kim YH, Kim YW: Additional antihypertensive effect of magnesium supplementation with an angiotensin II receptor blocker in hypomagnesemic rats. Korean J Intern Med. 2013 Mar;28(2):197-205. doi: 10.3904/kjim.2013.28.2.197. Epub 2013 Feb 27. [Article]
Touyz RM, Milne FJ: Magnesium supplementation attenuates, but does not prevent, development of hypertension in spontaneously hypertensive rats. Am J Hypertens. 1999 Aug;12(8 Pt 1):757-65. [Article]
Kh R, Khullar M, Kashyap M, Pandhi P, Uppal R: Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats. J Hypertens. 2000 Jul;18(7):919-26. [Article]
Yu L, Xu L, Xu M, Wan B, Yu L, Huang Q.: Role of Mg2+ ions in protein kinase phosphorylation: insights from molecular dynamics simulations of ATP-kinase complexes Molecular Simulation. 2011 September 20;37(14):1143-1150. [Article]
29. (2012). In Rang and Dale's Pharmacology (7th ed., pp. 364). Edinburgh: Elsevier/Churchill Livingstone. [ISBN:978-0-7020-3471-8]
46. (2011). In Goodman and Gilman's the pharmacological basis of therapeutics, Pharmacological basis of therapeutics (12th ed.). New York: McGraw-Hill. [ISBN:9780071624428]
2. (2013). In Clinical naturopathic medicine (pp. 76-78). Elsevier Health Sciences, 2013. [ISBN:9780729582261]
Civitelli, R., Ziambaras, K. and Leelawattana, R. (1997). 6. In Metabolic Bone Disease and Clinically Related Disorders (pp. 191-194). Academic Press. [ISBN:9780080536279]
Santa Cruz Biotechnology [Link]
PLASMA-LYTE 56 and 5% Dextrose Injection (Multiple Electrolytes and Dextrose Injection, Type 1, USP) in VIAFLEX Plastic Container: Drug Label [Link]
Magnesium Absorption in Humans [Link]
TOXNET Magnesium compounds [Link]

External Links

PubChem Compound: 134717
PubChem Substance: 347827845
ChemSpider: 118734
RxNav: 317246
ChEMBL: CHEMBL3989858
Wikipedia: Magnesium_acetate

MSDS

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Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
3	Completed	Treatment	Critically Ill Patients	1
3	Completed	Treatment	Parenteral Nutrition for Patients With Proven Insufficient Enteral Resorption	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Injection, emulsion	Parenteral
Emulsion	Parenteral
Emulsion	Intravenous
Injection, solution
Injection, emulsion	Intravenous	4.656 g/1000ml
Injection, emulsion	Intravenous	6.792 g/1000ml
Injection, emulsion	Intravenous
Injection	Intravenous
Injection, solution	Intravenous
Solution	Parenteral

Prices

Not Available

Patents

Not Available

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	80	Fischer Scientific MSDS
boiling point (°C)	117.1 °C at 760 mmHg	Predicted value by Santa Cruz Biotechnology
water solubility	Soluble	Fischer Scientific MSDS

Predicted Properties

Property	Value	Source
Water Solubility	98.2 mg/mL	ALOGPS
logP	0.29	ALOGPS
logP	-0.22	Chemaxon
logS	-0.16	ALOGPS
pKa (Strongest Acidic)	4.54	Chemaxon
Physiological Charge	-1	Chemaxon
Hydrogen Acceptor Count	2	Chemaxon
Hydrogen Donor Count	0	Chemaxon
Polar Surface Area	40.13 Å²	Chemaxon
Rotatable Bond Count	0	Chemaxon
Refractivity	23.48 m³·mol^-1	Chemaxon
Polarizability	4.96 Å³	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST): Not Available
Spectra: Not Available

Targets

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Details1. Glutamate (NMDA) receptor (Protein Group)

Kind: Protein group
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Voltage-gated cation channel activity
Specific Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic p...

Components:

Name	UniProt ID
Glutamate receptor ionotropic, NMDA 1	Q05586
Glutamate receptor ionotropic, NMDA 2A	Q12879
Glutamate receptor ionotropic, NMDA 2B	Q13224
Glutamate receptor ionotropic, NMDA 2C	Q14957
Glutamate receptor ionotropic, NMDA 2D	O15399
Glutamate receptor ionotropic, NMDA 3A	Q8TCU5
Glutamate receptor ionotropic, NMDA 3B	O60391

Drug created at November 30, 2015 19:10 / Updated at May 21, 2021 10:21

Magnesium acetate tetrahydrate

Identification

Structure for Magnesium acetate tetrahydrate (DB09409)

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Components: