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Nedosiran
go.drugbank.com/drugs/DB17635ApprovedInvestigational[A261690] Oxalate, particularly calcium oxalate, precipitation is the main cause of kidney stones formation; therefore, blocking the production of oxalate can help alleviate renal symptoms. … Nedosiran is an RNA interference targeting hepatic lactate dehydrogenase, the enzyme responsible for the conversion of glyoxylate to oxalate.
Synonyms: DCR-PHXC free acidInulin
go.drugbank.com/drugs/DB00638ApprovedInvestigationalNutraceuticalA starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan.
Categories: Compounds used in a research, industrial, or household settingTriclabendazole
go.drugbank.com/drugs/DB12245ApprovedInvestigationalThese parasites can infect humans following ingestion of larvae in contaminated water or food. … Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesOmega-3 fatty acids
go.drugbank.com/drugs/DB11133ApprovedInvestigationalNutraceuticalOmega-3 fatty acids play a critical role in metabolism and cellular function and they are available as daily supplements. On September 8, 2004, the U.S. … Omega-3 fatty acids are polyunsaturated fatty acids (PUFAs) with a double bond at the third carbon atom from the end of the carbon chain.
Synonyms: n-3 PUFAs, n-3 fatty acidsMixtures: Se-Tan DHA, Se-Tan DHARezafungin
go.drugbank.com/drugs/DB16310ApprovedInvestigationalRezafungin has a half-life higher than 130 hours and can be administered once a week instead of daily. … Rezafungin is an echinocandin antifungal drug.
Categories: Heterocyclic Compounds, 1-RingSynonyms: Echinocandin B, 1-((4R,5R)-4-hydroxy-N2-((4''-(pentyloxy)(1,1':4',1''-terphenyl)-4-yl)carbonyl)-5-(2-(trimethylammonio)ethoxy)-l-ornithine)-4-((4S)-4-hydroxy-4-(4-hydroxyphenyl)-l-allothreonine)-Bictegravir
go.drugbank.com/drugs/DB11799ApprovedInvestigationalIt has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet.[L43677] … Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection.
Categories: MATE 1 Inhibitors, Cytochrome P-450 SubstratesMagnesium trisilicate
go.drugbank.com/drugs/DB09281ApprovedMagnesium trisilicate is an inorganic compound that is used as an antacid in the treatment of peptic ulcers.
Mixtures: Mag-A-folic Tab, แม๊ก 2Talimogene laherparepvec
go.drugbank.com/drugs/DB13896ApprovedInvestigationalIn general, talimogene laherparepvec has been modified so that it can infect and multiply inside melanoma cells [L2221]. … Talimogene laherparepvec is an oncolytic treatment used in local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in patients with recurrent melanoma.
Synonyms: T Vec, T-VecSulfadoxine
go.drugbank.com/drugs/DB01299ApprovedInvestigationalWithdrawnA long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.
Synonyms: 4-Sulfanilamido-5,6-dimethoxypyrimidineNylidrin
go.drugbank.com/drugs/DB06152ApprovedWithdrawnNylidrin is a peripheral vasodilator. … This effect may help to improve memory/judgment, improve walking ability, and support the healing of frostbite/ulcers [L2283].
Categories: 2-Amino-1-Phenylethanol Derivatives, Cytochrome P-450 Substrates