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Displaying results 1271 - 1280 of 10000 in total
  1. Pathway

    Mercaptopurine Action Pathway

    smpdb.ca/view/SMP0000428
    Drug action

    Mercaptopurine is a purine antimetabolite prodrug that exerts cytotoxic effects via three mechanisms: via incorporation of thiodeoxyguanosine triphosphate into DNA and thioguanosine triphosphate into RNA, inhibition of de novo synthesis ...

    Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +26 more
    Enzymes: Thiopurine S-methyltransferase
  2. Drug

    Metoprolol

    go.drugbank.com/drugs/DB00264
    ApprovedInvestigational

    Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release. … [T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is widely prescribed in the Netherlands, New Zealand, and the US.

    Mixtures: METOPROLOL HCT S 100/12.5, METOPROLOL HCT S 100/12.5Categories: Cytochrome P-450 Substrates, Adrenergic beta-1 Receptor Antagonists
  3. Pathway

    Thioguanine Action Pathway (old)

    smpdb.ca/view/SMP0000430
    Drug action

    Thioguanine is a purine antimetabolite prodrug closely related to mercaptopurine and similarly inhibits purine metabolism. The thioguanine pathway is shown as a part of the mercaptopurine pathway. Thioguanine exerts cytotoxic effects via...

    Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +27 more
    Enzymes: Thiopurine S-methyltransferase
  4. Drug

    Rice bran

    go.drugbank.com/drugs/DB14361
    Approved

    Rice bran is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

    Mixtures: Ari S-Liner
  5. Drug

    Briakinumab

    go.drugbank.com/drugs/DB05459
    Investigational

    As of 2011 drug development for psoriasis has been discontinued in the U.S. and Europe. … Briakinumab is a human anti-IL-12 monoclonal antibody being developed for the treatment of a number of T-cell driven autoimmune diseases.

  6. Drug

    Bisacodyl

    go.drugbank.com/drugs/DB09020
    ApprovedInvestigational

    Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation. … [A233290,A233300,A207700] Bisacodyl was patented on 25 September 1956[L33045] but has been used as a laxative since 1952.[A233300]

    Mixtures: Gentlax S, BEKUNIS 3 MG/5 MG KAPLI TABLET, 30 ADETSynonyms: Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester)
  7. Drug

    Clavulanic acid

    go.drugbank.com/drugs/DB00766
    ApprovedInvestigationalVet approved

    [A182228]When it is combined with amoxicillin, clavulanic acid is frequently known as Augmentin, Co-Amoxiclav, or Clavulin.[L7880,L7904,L7910] … Clavulanic acid is a beta-lactamase inhibitor that is frequently combined with [Amoxicillin] or [Ticarcillin] to fight antibiotic resistance by preventing their degradation by beta-lactamase enzymes, broadening

    Mixtures: CLAMOXIN S, AMOXICILLINA E ACIDO CLAVULANICO SANDOZ A/SCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  8. Drug

    Sacituzumab govitecan

    go.drugbank.com/drugs/DB12893
    ApprovedInvestigational

    [A193671] One such ADC is sacituzumab govitecan, which combines a humanized anti-trophoblast cell-surface antigen 2 (TROP-2) antibody with the topoisomerase I inhibitor SN-38. … [A193653] In November 2021 and July 20 2023, sacituzumab govitecan was also approved by the European Commission and Health Canada respectively.[L39372,L47601]

    Categories: Trop-2-Directed Monoclonal AntibodiesProducts: TRODELVY®, TRODELVY 200 MG İNFÜZYONLUK ÇÖZELTİ KONSANTRESİ İÇİN TOZ, 1 ADET
  9. Drug

    Budesonide

    go.drugbank.com/drugs/DB01222
    ApprovedInvestigational

    Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis. … [L10598] It is also available in a combination product with [formoterol].[L10619]

    Mixtures: DUORESP SP 320/9UG 1X60ED, DUORESP SP 320/9UG 1X60EDCategories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  10. Drug

    Methenamine

    go.drugbank.com/drugs/DB06799
    ApprovedInvestigationalVet approved

    Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. … In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine).

    Mixtures: Urin D/S, Uretron D/SProducts: NETURONE GRANUL LIBA, 70 G, NETURONE GRANUL LIBA, 105 G