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Displaying results 1271 - 1280 of 10000 in total
  1. Drug

    Imlunestrant

    go.drugbank.com/drugs/DB19043
    ApprovedInvestigational

    progression on at least one line of endocrine therapy. … The FDA approved imlunestrant on September 25, 2025 [L54051] as a treatment for estrogen receptor (ER)-positive, HER2-negative, estrogen receptor 1 (ESR1)-mutated advanced or metastatic breast cancer with

    Synonyms: (5r)-5-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-8-(trifluoromethyl)-5h-(1)benzopyrano(4,3-c)quinolin-2-ol, 5h-(1)benzopyrano(4,3-c)quinolin-2-ol, 5-(4-(2-(3-(fluoromethyl)-1-azetidinyl)ethoxy)phenyl)-8-(trifluoromethyl)-, (5r)-
  2. Drug

    Cyclothiazide

    go.drugbank.com/drugs/DB00606
    Approved

    The antihypertensive mechanism of cyclothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance … It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.

    Categories: combinations of sulfonamides
  3. Drug

    Baloxavir marboxil

    go.drugbank.com/drugs/DB13997
    ApprovedInvestigational

    [A39895, A251755] It is a prodrug of [baloxavir] [L42855] with an improved absorption profile than its active metabolite due to the addition of a phenolic hydroxyl group to its structure. … [L4779] It was also approved by the European Commission on January 7, 2021.[L45241]

  4. Drug

    Acyclovir

    go.drugbank.com/drugs/DB00787
    ApprovedInvestigational

    [L7321] Acyclovir was granted FDA approval on 29 March 1982.[L7318] … [L7303,L7315,L7318,L7321,L7324,L7327] Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old.

    Mixtures: Activir Duo 50 mg/g + 10 mg/g CremeProducts: AVIREX-U
  5. Drug

    Zidovudine

    go.drugbank.com/drugs/DB00495
    ApprovedInvestigational

    A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. … This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains.

    Mixtures: ZOVILAM PED DT®, N/ACategories: Antivirals used in combination for the treatment of HIV infections
  6. Drug

    NKG2D-ACE2 CAR-NK Cell

    go.drugbank.com/drugs/DB15727
    Investigational

    The ACE2 is a receptor for SARS-Cov-2, binding to the S-protein of the viral envelope and competitively inhibiting SARS-Cov-2 infection of type II alveolar epithelial cells. … Chimeric antigen receptors (CARs) are artificial receptors consisting of an antibody-derived antigen binding domain and transmembrane and signaling domains from T-cell receptor signalling moieties.

  7. Drug

    Ofatumumab

    go.drugbank.com/drugs/DB06650
    ApprovedInvestigational

    [L12753] The FDA subsequently approved ofatumumab for the treatment of RMS on August 20, 2020. … Ofatumumab is used as monotherapy or in combination with other medications, depending on the patient profile and previous treatment history.

    Categories: CD20 (Clusters of Differentiation 20) inhibitorsProducts: KESIMPTA SOLUTION FOR INJECTION IN PRE-FILLED PEN 20MG/0.4ML, Bonspri 20mg/0.4mL Solution for Injection in Pre-filled syringe
  8. Drug

    Levoketoconazole

    go.drugbank.com/drugs/DB05667
    Approved

    [A244078, A244083] [Ketoconazole] has been used both on- and off-label to treat CS due to its ability to inhibit cortisol production. … [A244083] Levoketoconazole is one of two enantiomers present in racemic [ketoconazole].

  9. Drug

    Methylergometrine

    go.drugbank.com/drugs/DB00353
    ApprovedInvestigational

    A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)

    Categories: Heterocyclic Compounds with 4 or More RingsSynonyms: 9,10-Didehydro-N-[1-(hydroxymethyl)-propyl]-D-lysergamide, D-lysergic acid 1-butanolamide
  10. Drug

    Prothrombin

    go.drugbank.com/drugs/DB11311
    ApprovedInvestigational

    Prothrombin Complex Concentrate (Human), is indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with

    Mixtures: OCTAPLEX POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU, COFACT 250 IU/10 ML IV ENJEKSIYON IÇIN TOZ IÇEREN FLAKON, 1 ADET