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Displaying results 1271 - 1280 of 10000 in total
  1. Drug

    Cidofovir

    go.drugbank.com/drugs/DB00369
    ApprovedInvestigational

    Cidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis.[FDA label] I...

    Categories: Heterocyclic Compounds, 1-RingSynonyms: (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine, (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine
  2. Drug

    Phylloquinone

    go.drugbank.com/drugs/DB01022
    ApprovedInvestigational

    of vitamin K. … [L33319,L33345] Phylloquinone is a cofactor of the enzyme γ-carboxylase, which modifies and activates precursors to coagulation factors II, VII, IX, and X.

    Mixtures: CALCIDOSE 1200 MG/800 IU/65 MCG EFERVESAN TABLET, 45 ADET, CALCIDOSE 600 MG/400 IU/32.5 MCG EFERVESAN TABLET, 30 ADETCategories: Vitamin K
  3. Drug

    TPCA-1

    go.drugbank.com/drugs/DB17058
    Experimental

    TPCA-1 is a selective inhibitor of human IκB kinase 2 (IKK-2).[A253152]

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide, 3-thiophenecarboxamide, 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-
  4. Drug

    Cholesteryl chloride

    go.drugbank.com/drugs/DB14045
    Experimental

    Cholesteryl chloride, also known as 3-chlorocholest-5-ene, is an organochloride derivative of cholesterol. It is presented as a liquid crystal that forms clockwise liquid crystals.

    Synonyms: 3-Chlorocholest-5-ene, 3-Chlorocholestene
  5. Drug

    Rezafungin

    go.drugbank.com/drugs/DB16310
    ApprovedInvestigational

    Rezafungin has a half-life higher than 130 hours and can be administered once a week instead of daily. … [A258393,L45633] Unlike other echinocandins such as [caspofungin] and [micafungin], rezafungin has long‐acting pharmacokinetics and a high stability that allows for it to have long dosing intervals maintaining

    Categories: Heterocyclic Compounds, 1-RingSynonyms: Echinocandin B, 1-((4R,5R)-4-hydroxy-N2-((4''-(pentyloxy)(1,1':4',1''-terphenyl)-4-yl)carbonyl)-5-(2-(trimethylammonio)ethoxy)-l-ornithine)-4-((4S)-4-hydroxy-4-(4-hydroxyphenyl)-l-allothreonine)-
  6. Drug

    BO-653

    go.drugbank.com/drugs/DB19216
    Investigational

    BO-653 is under investigation in clinical trial NCT00055510 (A Blinded Study Conducted at Multiple Centers Evaluating Various Doses of an Investigational Agent (BO-653) Against Placebo, for Safety and

    Categories: Heterocyclic Compounds, 2-RingSynonyms: 4,6-bis(1,1-dimethylethyl)-2,3-dihydro-2,2-dipentyl-5-benzofuranol
  7. Drug

    Metamizole

    go.drugbank.com/drugs/DB04817
    ApprovedInvestigationalWithdrawn

    Approvals of the NDA's for metamizole drug products were withdrawn on June 27, 1977 (see the Federal Register of June 17, 1977, 42 FR 30893). … Metamizole (dipyrone) is a pyrazolone derivative that belongs to the group of nonacid nonopioids. It is considered a potent analgesic and antipyretic with favourable gastrointestinal tolerability.

    Mixtures: DIPIRONA 300 MG + ISOMETEPTENO 50 MG + CAFEINA 30 MG GOTAS, DIPIRONA 2.5 G + HIOSCINA 20 MG/5 ML SOLUCION INYECTABLECategories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 CYP3A Inducers
  8. Drug

    Prasterone sulfate

    go.drugbank.com/drugs/DB05804
    Investigational

    DHEA-S is the principal adrenal androgen and is secreted together with cortisol under the control of ACTH and prolactin. DHEA-S is elevated with hyperprolactinemia.

    Categories: Cytochrome P-450 CYP3A7 Substrates, 17-KetosteroidsSynonyms: (3-beta)-3-(Sulfooxy)androst-5-en-17-one, 3beta-Hydroxyandrost-5-en-17-one 3-sulfate
  9. Drug

    ACV tripeptide

    go.drugbank.com/drugs/DB02025
    Experimental

    Synonyms: N-[L-5-Amino-5-carboxypentanoyl]-L-cysteinyl-D-valine, 5-(2-Aminoad)-cys-val
  10. Drug

    Alirocumab

    go.drugbank.com/drugs/DB09302
    ApprovedInvestigational

    Alirocumab is a biopharmaceutical that obtained FDA approval in July 2015 as a second line treatment for high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of … PCSK9 inhibition facilitates more LDL-C clearance from the blood.

    Categories: Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) InhibitorsProducts: PRALUENT 75 MG/ML (SOLUTION FOR INJECTION IN PRE-FILLED PEN), Praluent 75 mg solution for injection in pre-filled pen