Metamizole is an antipyretic and analgesic drug used to relieve severe and persistent fever and pain. Metamizole (dipyrone) is a pyrazolone derivative that belongs to the group of nonacid nonopioids.
- Mechanism
- Curator reviewed · 7 references
The mechanism of action of metamizole is not fully understood. Its active metabolites, 4-methyl-amino-antipyrine (MAA) and 4-amino-antipyrine (AA), inhibit prostaglandin E2 (PGE2)-induced hyperalgesia. It has been suggested that the anti-hyperalgesic effect of MAA is mediated by guanosine 3',5'-cyclic monophosphate (cGMP) activation and ATP-sensitive potassium channel opening, while the effects of AA are associated with the activation of cannabinoid receptor type 1 (CB1). Metamizole is classified in some sources as a weak non-steroidal anti-inflammatory drug (NSAID); however, evidence suggests that its analgesic effects do not depend on its anti-inflammatory properties. Although the inhibition of cyclooxygenase (COX) 2 may play a role in the central nervous system effects of metamizole, reports suggest that metamizole inhibits COX-3 with a higher affinity compared to COX-1 or COX-2.
- Primary indication
- Metamizole is banned in several countries, where it was previously used as a powerful analgesic and fever reducer.Curator reviewed · 4 structured indications
- Formula / weight
- C13H17N3O4S · 311.36 g/mol (avg)
- Also known as
- Dipyrone
Resolves to
LVWZTYCIRDMTEY-UHFFFAOYSA-NSMILESCN(CS(O)(=O)=O)C1=C(C)N(C)N(C1=O)C1=CC=CC=C1What you can answer from here — as of September 28, 2026
Which drugs share a target with Metamizole, and which of those have an active Phase 3 trial?
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