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Cytochrome P450 2C8
go.drugbank.com/bio_entities/BE0002887TargetEnzymeHumansA cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576, PubMed:7574697). Mecha...
Synonyms: S-mephenytoin 4-hydroxylaseHematopoietic prostaglandin D synthase
go.drugbank.com/bio_entities/BE0001167TargetHumansBifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide rang...
Synonyms: Glutathione S-transferase4-aminobutyrate aminotransferase GabT
go.drugbank.com/bio_entities/BE0001510TargetEscherichia coli (strain K12)Pyridoxal phosphate-dependent enzyme that catalyzes transamination between primary amines and alpha-keto acids. Catalyzes the transfer of the amino group from gamma-aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semia...
Synonyms: (S)-3-amino-2-methylpropionate transaminaseMyosin regulatory light chain 12A
go.drugbank.com/bio_entities/BE0004293TargetHumansMyosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity)
Synonyms: HEL-S-24Prostaglandin E synthase
go.drugbank.com/bio_entities/BE0011075TargetHumansTerminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inf...
Synonyms: Microsomal glutathione S-transferase 1-like 1Galectin-1
go.drugbank.com/bio_entities/BE0004493TargetHumansLectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylati...
Synonyms: S-Lac lectin 1P2 Purinoceptors
go.drugbank.com/bio_entities/BE0009827TargetThe affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP … G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues.
Polypeptides: S-geranylgeranyl-glutathione receptor P2RY8Aldo-keto reductase family
go.drugbank.com/bio_entities/BE0009802EnzymeHumansAlso acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (PubMed:30538128). … Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (PubMed:31649033). Displays no reductase activity towards retinoids (By similarity)
Synonyms: S-nitroso-CoA reductaseVoltage-gated Potassium Channels
go.drugbank.com/bio_entities/BE0009847TargetA-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain (PubMed:15454437). Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons. Exhibits a low-threshol...
Synonyms: Potassium voltage-gated channel subfamily S member 3, Potassium voltage-gated channel modifier subfamily S member 1Free methionine-R-sulfoxide reductase
go.drugbank.com/bio_entities/BE0003187TargetEscherichia coli (strain K12)Specific for free L-methionine-(R)-S-oxide.
Function: L-methionine-(R)-S-oxide reductase activity