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Pilocarpine M1 Saliva Excretion Action Pathway
smpdb.ca/view/SMP0126678Drug actionThe sweat, salivary, lacrimal, gastric, pancreatic, and intestinal glands and the mucous cells of the respiratory tract may be stimulated. Pilocarpine is a cholinergic parasympathomimetic agent. … It increase secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors.
Enzymes: Chloride intracellular channel protein 2Cevimeline M1 Saliva Excretion Action Pathway
smpdb.ca/view/SMP0126680Drug actionMuscarinic agonists in sufficient dosage can increase secretion of exocrine glands, such as salivary and sweat glands and increase tone of the smooth muscle in the gastrointestinal and urinary tracts. … It is administered as an oral tablet and can be found under the brand name Evoxac.
Enzymes: Chloride intracellular channel protein 2Ethacrynic Acid Diuretic Action Pathway
smpdb.ca/view/SMP0124515Drug actionThis is relieves symptoms such as swelling/ edema and hypertension in patients. Ethacrynic acid may also inhibit sodium and chloride reabsorption in the proximal and distal tubules. … Ethacrynic acid binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen.
Enzymes: Chloride channel protein ClC-KaTorasemide Action Pathway (New)
smpdb.ca/view/SMP0124537Drug actionTorasemide binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen. … The K+/Cl- co-transporter moves K+ and Cl- from the cell into the peritubular fluid and the Cl- channel transports Cl- from the cell into the peritubular fluid.
Enzymes: Chloride channel protein ClC-KaLafutidine H2 Anti-Histamine Action Pathway
smpdb.ca/view/SMP0051038Drug actionLafutidine (also known as INN) is a second generation histamine H2 receptor antagonist that can be used for treating ulcers and reflux. … Inhibition of histamine H2 receptor can inhibit histamine-stimulated gastric acid secretion which will lead to reduced gastric volume and acidity.
Enzymes: Chloride intracellular channel protein 2Rabeprazole Antacid Action Pathway
smpdb.ca/view/SMP0123294Drug actionThe bicarbonate ions go into the blood via the chloride anion exchanger on the basolateral membrane which exchanges the hydrogen bicarbonate for Cl- ions. … In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+.
Enzymes: Chloride anion exchangerOmeprazole Action Pathway
smpdb.ca/view/SMP0122674Drug actionThe bicarbonate ions go into the blood via the chloride anion exchanger on the basolateral membrane which exchanges the hydrogen bicarbonate for Cl- ions. … In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+.
Enzymes: Chloride anion exchangerEsomeprazole Action Pathway
smpdb.ca/view/SMP0123196Drug actionThe bicarbonate ions go into the blood via the chloride anion exchanger on the basolateral membrane which exchanges the hydrogen bicarbonate for Cl- ions. … In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+.
Enzymes: Chloride anion exchangerLansoprazole Action Pathway
smpdb.ca/view/SMP0123261Drug actionThe bicarbonate ions go into the blood via the chloride anion exchanger on the basolateral membrane which exchanges the hydrogen bicarbonate for Cl- ions. … In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+.
Enzymes: Chloride anion exchangerBumetanide Diruretic Action Pathway
smpdb.ca/view/SMP0124517Drug actionBumetanide binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen. … The K+/Cl- co-transporter moves K+ and Cl- from the cell into the peritubular fluid and the Cl- channel transports Cl- from the cell into the peritubular fluid.
Enzymes: Chloride channel protein ClC-Ka