Search

Displaying results 121 - 130 of 1841 in total
  1. Pathway

    Polythiazide Action Pathway

    smpdb.ca/view/SMP0000080
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Polythiazide · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  2. Pathway

    Bendroflumethiazide Action Pathway

    smpdb.ca/view/SMP0000090
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Bendroflumethiazide · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  3. Pathway

    Ethacrynic Acid Action Pathway

    smpdb.ca/view/SMP0000097
    Drug action

    Etacrynic acid (also known as ethacrynic acid and Edecrin) is a loop diuretic that can inhibit water reabsorption by binding and inhibiting solute carrier family 12 member 1 (also known as sodium-potassium-chloride

    Drugs: Cysteine · Etacrynic acid · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  4. Pathway

    Indapamide Action Pathway

    smpdb.ca/view/SMP0000110
    Drug action

    Sodium-chloride symporter (also known as solute carrier family 12 member 3) can translocate chloride and sodium from lumen to epithelial cell. … Sodium-potassium ATPase can export sodium from cell to basolateral interstitium, which lead to increased osmolarity in interstitum for later water reabsorption.

    Drugs: Cysteine · Indapamide · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  5. Pathway

    Kidney Function

    smpdb.ca/view/SMP0000483
    Physiological

    Blood pressure is regulated by the hormones angiotensin II and aldosterone, which increases sodium chloride reabsorption. … Only water is reabsorbed in the thin descending loop of Henle, while sodium, chlorine and potassium are reabsorbed in the thick ascending loop of Henle.

    Drugs: Cysteine · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  6. Pathway

    Eplerenone Action Pathway (Old)

    smpdb.ca/view/SMP0000135
    Drug action

    Aldosterone increases sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium-potassium ATPases as well as luminal (apical) sodium and potassium channels. … Potassium entering the nephron lumen is subsequently excreted in the urine.

    Drugs: Cysteine · Eplerenone · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  7. Pathway

    Triamterene Action Pathway

    smpdb.ca/view/SMP0000132
    Drug action

    Potassium secretion is indirectly affected by the inhibition of sodium reabsorption due to the elimination of the electrochemical gradient that drives potassium loss. … This leads to an increase in serum potassium concentration -- a common action for potassium-sparing drugs -- and has the potential to induce hyperkalemia which can potentially lead to severe heart arrhythmias

    Drugs: Cysteine · Triamterene · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  8. Pathway

    Spironolactone Action Pathway

    smpdb.ca/view/SMP0000134
    Drug action

    Aldosterone increases sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium-potassium ATPases as well as luminal (apical) sodium and potassium channels. … Potassium entering the nephron lumen is subsequently excreted in the urine.

    Drugs: Cysteine · Spironolactone · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  9. Pathway

    Quinethazone Action Pathway (old)

    smpdb.ca/view/SMP0000091
    Drug action

    In the case of quinethazone, it inhibits the sodium-chloride symporter, solute carrier family 12 member 3. Thiazides also inhibit sodium ion transport. … The short term mechanism of action is relatively well-understood: thiazides inhibit sodium-chloride co-transport into the renal distal convoluted tubule of the nephron and therefore increase fluid loss

    Drugs: Cysteine · Quinethazone · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3
  10. Pathway

    Amiloride Action Pathway

    smpdb.ca/view/SMP0000133
    Drug action

    The drug is also potassium sparing. Potassium is typically excreted due to the electrochemical gradient produced by sodium reabsorption. … Amiloride causes an increase in sodium excretion and a decrease in potassium secretion. The drug is typically prescribed to patients with depleted potassium.

    Drugs: Cysteine · Amiloride · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3