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Fenfluramine
go.drugbank.com/drugs/DB00574ApprovedIllicitInvestigationalWithdrawnDravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency an...
GABA-Transaminase Deficiency
smpdb.ca/view/SMP0000351DiseaseGABA-transaminase deficiency, also known as gamma-amino butyric acid transaminase (GABA-T) deficiency, is an extremely rare autosomal recessive inborn error of metabolism (IEM) that is caused by a defect in the ABAT gene, which codes for...
Enzymes: Sodium-coupled neutral amino acid transporter 4Carnosinuria, Carnosinemia
smpdb.ca/view/SMP0000493DiseaseCarnosinemia, also known as carnosinemia, is a rare inborn error of metabolism (IEM) and recessive autosomal disorder caused by a defective CNDP1 gene which encodes for carnosinase. Carnosinase is a dipeptidase enzyme that catalyzes the ...
Enzymes: Sodium-coupled neutral amino acid transporter 4Desvenlafaxine SNRI - Serotonin reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126423Drug actionThe exact mechanism of action of venlafaxine in the treatment of various psychiatric conditions has not been fully elucidated; however, it is understood that venlafaxine and its active metabolite O-desmethylvenlafaxine (ODV) potently and...
Enzymes: Sodium-dependent serotonin transporterCarnosinuria, Carnosinemia
smpdb.ca/view/SMP0125598DiseaseCarnosinemia, also known as carnosinemia, is a rare inborn error of metabolism (IEM) and recessive autosomal disorder caused by a defective CNDP1 gene which encodes for carnosinase. Carnosinase is a dipeptidase enzyme that catalyzes the ...
Enzymes: Sodium-coupled neutral amino acid transporter 4beta-Alanine Metabolism
smpdb.ca/view/SMP0000007MetabolicBeta-alanine, 3-aminopropanoic acid, is a non-essential amino acid. Beta-Alanine is formed by the proteolytic degradation of beta-alanine containing dipeptides: carnosine, anserine, balenine, and pantothenic acid (vitamin B5). These dipe...
Enzymes: Sodium-coupled neutral amino acid transporter 4GABA-Transaminase Deficiency: beta-alanine
smpdb.ca/view/SMP0125596DiseaseGABA-transaminase deficiency, also known as gamma-amino butyric acid transaminase (GABA-T) deficiency, is an extremely rare autosomal recessive inborn error of metabolism (IEM) that is caused by a defect in the ABAT gene, which codes for...
Enzymes: Sodium-coupled neutral amino acid transporter 4beta-Aminoisobutyric Aciduria
smpdb.ca/view/SMP0125597DiseaseHyper-beta-aminoisobutyric aciduria or BAIB urinary excretion is a common, autosomal recessive condition characterized by high levels of excretion of beta-aminoisobutyric acid in the urine. It is probably the most common mendelian metabo...
Enzymes: Sodium-coupled neutral amino acid transporter 4Citalopram Mechanism of Action Action Pathway New
smpdb.ca/view/SMP0126506Drug actionCitalopram binds selectively to the sodium dependent serotonin transporter and blocks the recycling of serotonin from the synapse.
Enzymes: Sodium-dependent serotonin transporterParoxetine Mechanism of Action Action Pathway New
smpdb.ca/view/SMP0126510Drug actionParoxetine selectively binds to the sodium dependent serotonin transporter (SERT) and blocks the recycling of serotonin from the synapse.
Enzymes: Sodium-dependent serotonin transporter