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Displaying results 1291 - 1300 of 10000 in total
  1. Pathway

    Droxidopa B2-Adrenergic Artery Dilation Action Pathway

    smpdb.ca/view/SMP0126493
    Drug action

    Droxidopa is a medication used to treat symptomatic neurogenic orthostatic hypotension (nOH) caused by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic failure caused by conditions such as Par...

    Drugs: ATP · Norepinephrine · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  2. Pathway

    Norepinephrine B2-Adrenergic Artery Dilation Action Pathway

    smpdb.ca/view/SMP0126573
    Drug action

    Norepinephrine is a sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. It can be found under the brand name Levophed. Precursor of epinephrine that i...

    Drugs: ATP · Norepinephrine · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  3. Pathway

    Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway

    smpdb.ca/view/SMP0126647
    Drug action

    By antagonizing the beta-1 adrenergic receptor and blocking G(s) signalling, smooth muscle constriction of the ciliary muscles of the eye make it more difficult for the aqueous humour to reach the eye.

    Drugs: ATP · Carteolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  4. Pathway

    Nadolol B2-Adrenergic Vasoconstriction Action Pathway

    smpdb.ca/view/SMP0126648
    Drug action

    Nadolol is a non-selective beta blocker. It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In bronchial and vascular smooth muscle, nadolol...

    Drugs: ATP · Nadolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  5. Pathway

    Gs Adrenergic Smooth Muscle Relaxation

    smpdb.ca/view/SMP0126934
    Physiological

    The mechanism of adrenoreceptors. Adrenaline or noradrenaline are receptor ligands to either α1, α2 or β-adrenoreceptors. The β receptor couples to Gs and increases intracellular cAMP activity, resulting in e.g. heart muscle contraction,...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  6. Drug

    Elranatamab

    go.drugbank.com/drugs/DB15395
    ApprovedInvestigational

    [L47820] Elranatamab was also approved by the European Commission on December 8, 2023.[L50437] … Elranatamab is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager.

    Synonyms: IMMUNOGLOBULIN G2-KAPPA, ANTI-(HOMO SAPIENS T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN CD3E (T-CELL SURFACE ANTIGEN T3/LEU-4 EPSILON CHAIN)), HUMAN-MUS MUSCULUS MONOCLONAL DISULFIDE WITH IMMUNOGLOBULIN, B-CELL MATURATION ANTIGEN (BCMA) CLUSTER OF DIFFERENTIATION 3 (CD3) BISPECIFIC MONOCLONAL ANTIBODY (MAB) ANTI-BCMA/ANTI-CD3 BISPECIFIC MABCategories: Bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager
  7. Drug

    Ergocalciferol

    go.drugbank.com/drugs/DB00153
    ApprovedInvestigationalNutraceutical

    [T580] Ergocalciferol is considered the first vitamin D analog and is differentiated from [cholecalciferol] by the presence of a double bond between C22 and C23 and the presence of a methyl group at … [T577] The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets.

    Synonyms: (5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol, (5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-olMixtures: Se-Natal, Calcium Magnesium Avec Vitamine D Et Zinc
  8. Drug

    Aprotinin

    go.drugbank.com/drugs/DB06692
    ApprovedInvestigationalWithdrawn

    Since it demonstrates the capacity to slow fibrinolysis, it has been employed to reduce bleeding during complex surgery such as heart and liver surgery. … The substance is consequently made available only for very restricted research use.

    Mixtures: TISSEEL FIBRIN SEALANT VH S/D (FROZEN), ŞTİ.EL LYO 1 ML TROMBIN ÇÖZELTİSİ VE 1 ML FIBRINOJEN ÇÖZELTİSİ ICEREN IKI BILESENLI FIBRIN YAPISTIRICI, SET 1 (2 İĞNE+2 ENJEKTÖR) VE SET 2 (2 İĞNE +2 ENJEKTÖR+1 ENJEKTÖR KLİPSİ+2 BİRLEŞTİRME PARÇASI+ 4
  9. Drug

    Avacopan

    go.drugbank.com/drugs/DB15011
    ApprovedInvestigational

    [A240249, A240254] Despite complex pathophysiology, studies over the past ~2 decades have identified a key role for the alternative complement pathway and, in particular, the interaction between the anaphylatoxin … [L38919] On January 19, 2022, the European Commission approved avacopan for the treatment of adult patients with severe, active granulomatosis polyangiitis (GPA) or microscopic polyangiitis (MPA) - the

    Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  10. Drug

    Apraclonidine

    go.drugbank.com/drugs/DB00964
    ApprovedInvestigational

    Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.

    Categories: Heterocyclic Compounds, 1-Ring, Adrenergic alpha-1 Receptor AgonistsSynonyms: 4-Aminoclonidine