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Displaying results 1301 - 1310 of 10000 in total
  1. Drug

    Benzatropine

    go.drugbank.com/drugs/DB00245
    ApprovedInvestigational

    [A37914] Benztropine was developed by USL Pharma and officially approved by the FDA on 1996.[L5500] … It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970.

    Synonyms: benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether, 3α-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octaneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 Substrates
  2. Drug

    Thrombin

    go.drugbank.com/drugs/DB11300
    ApprovedInvestigational

    Medical thrombin is a protein substance produced through a conversion reaction in which prothrombin of bovine origin is activated by tissue thromboplastin in the presence of calcium chloride. … Thrombin requires no intermediate physiological agent for its action. It clots the fibrinogen of the blood directly.

    Synonyms: coagulation factor IIMixtures: SAN. VE TİC. LTD., TACHOSİL 5,5 MG/CM2 İNSAN FİBRİNOJENİ VE 2.0 IU/CM2 İNSAN TROMBİNİ İLAÇLI SÜNGER
  3. Pathway

    Tetrakis(2-methoxyisobutylisocyanide)copper(I) tetrafluoroborate Drug Metabolism

    smpdb.ca/view/SMP0130603
    Metabolic

    Tetrakis(2-methoxyisobutylisocyanide)copper(I) tetrafluoroborate passes through the liver and is then excreted from the body mainly through the kidney. … Tetrakis(2-methoxyisobutylisocyanide)copper(I) tetrafluoroborate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Tetrakis(2-methoxyisobutylisocyanide)copper(I) tetrafluoroborate
  4. Drug

    Mitapivat

    go.drugbank.com/drugs/DB16236
    ApprovedInvestigational

    [A245478] On February 17, 2022, the FDA approved mitapivat as the first disease-modifying treatment for hemolytic anemia in adults with pyruvate kinase (PK) deficiency, a rare, inherited disorder leading … Mitapivat is a novel, first-in-class pyruvate kinase activator. It works to increase the activity of erythrocyte pyruvate kinase, a key enzyme involved in the survival of red blood cells.

    Synonyms: Pkr-in-1Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  5. Drug

    Trastuzumab deruxtecan

    go.drugbank.com/drugs/DB14962
    ApprovedInvestigational

    [A188988] Trastuzumab deruxtecan was developed by Daiichi Sankyo in collaboration with AstraZeneca and was first approved by the FDA in 2019.[L10842] … [L10842] It is classified as an antibody-drug conjugate. The cleavable peptide linker used to bind the antibody and drug in this product distinguishes it from other members of its class.

    Synonyms: T-DXd, T- DXdCategories: MATE 2 Substrates, P-glycoprotein substrates
  6. Target

    Inhibitor of nuclear factor kappa-B kinase subunit beta

    go.drugbank.com/bio_entities/BE0001154
    TargetHumans

    Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, P...

    Synonyms: I-kappa-B kinase 2, I-kappa-B-kinase beta
  7. Drug

    Palovarotene

    go.drugbank.com/drugs/DB05467
    Approved

    It first garnered interest as a potential treatment for emphysema but was eventually recognized as a potential novel therapy for patients with FOP. … [L40010] On August 16, 2023, palovarotene was also approved by the FDA for the management of HO associated with FOP.[L47845]

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 Inducers
  8. Drug

    Gelatin

    go.drugbank.com/drugs/DB11242
    ApprovedInvestigationalVet approvedWithdrawn

    An increasing number of novel applications have been found for collagen and gelatin.[A32426] Gelatin is generally recognized as safe (GRAS) by the FDA to be a non-hazardous food or food ingredient. … [A32432] Some alternative raw substances have recently garnered attention from both researchers and the industry not only because they overcome religious concerns shared by both Jews and Muslims but

    Mixtures: GELOFUSINE® ISO 4%, GELOFUSINE IN 500ML PLASTIC CONTAINERProducts: INFUSOL SG (SUCCINYLATED GELATIN (Bovine) INTRAVENOUS INFUSION 4% w/v), GELAFUNDIN 4
  9. Drug

    Papain

    go.drugbank.com/drugs/DB11193
    ApprovedWithdrawn

    Papain is also used as an ingredient in various enzymatic debriding preparations. … Papain, also known as papaya proteinase I, is a cysteine protease (EC 3.4.22.2) enzyme that is found in species of papaya, _Carica papaya_ and _Vasconcellea cundinamarcensis_.

    Mixtures: Herbalax Forte No 70 Tab, Neo Life Enzyme TabProducts: PRODEGEL ®, BEAUTIFUL CONTRACT - Deep V Breast contract -Hui Ju Sheng Enterprise Corporation Ltd.
  10. Drug

    Grepafloxacin

    go.drugbank.com/drugs/DB00365
    ApprovedWithdrawn

    Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States … Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections.

    Categories: Topoisomerase II Inhibitors, 4-Quinolones