Cardio-spect

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Cardiolite
Generic Name
Tetrakis(2-methoxyisobutylisocyanide)copper(I) tetrafluoroborate
Commonly known or available as Cardio-spect
DrugBank Accession Number
DB14106
Background

Tetrakis (2-methoxyisobutylisocyanide) copper (I) tetrafluoroborate is a component of Cardiolite, a technetium Tc99m-based imaging agent used for assessing myocardial perfusion.1

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 602.99
Monoisotopic: 602.268772
Chemical Formula
C24H44BCuF4N4O4
Synonyms
  • Cardio-spect
  • Tetrakis (2-methoxyisobutyl isonitrile) copper (I) tetrafluoroborate

Pharmacology

Indication

Not Available

Pharmacology
Reduce drug development failure rates
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
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Avoid life-threatening adverse drug events & improve clinical decision support.
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products2
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dosage, form, labeller, route of administration, and marketing period.
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Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
CardioliteInjection, powder, lyophilized, for solution1 mg/1mLIntravenousLantheus Medical Imaging, Inc.1990-12-20Not applicableUS flag
Kit for the Preparation of Technetium Tc99m SestamibiInjection, powder, lyophilized, for solution1 mg/1mLIntravenousLantheus Medical Imaging, Inc.1990-12-20Not applicableUS flag
SestamibiInjection, powder, lyophilized, for solution1.5 mg/1IntravenousAnazao Health Corporation2012-05-23Not applicableUS flag
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Technetium Tc 99m SestamibiInjection1 mg/1mLIntravenousCurium US LLC2011-10-31Not applicableUS flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
STAMICIS 1 mg Kit for Radiopharmaceutical PreparationKitQUANTARAD TECHNOLOGIES SDN BHD2020-09-08Not applicableMalaysia flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
SestamibiTetrakis(2-methoxyisobutylisocyanide)copper(I) tetrafluoroborate (1.5 mg/1)Injection, powder, lyophilized, for solutionIntravenousAnazao Health Corporation2012-05-23Not applicableUS flag

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
N6OU7HJ70P
CAS number
103694-84-4
InChI Key
WJRFSUVOHUMYAO-UHFFFAOYSA-N
InChI
InChI=1S/4C6H11NO.BF4.Cu/c4*1-6(2,8-4)5-7-3;2-1(3,4)5;/h4*5H2,1-2,4H3;;/q;;;;-1;+1
IUPAC Name
lambda1-copper(1+) tetrakis(1-isocyano-2-methoxy-2-methylpropane) tetrafluoroboranuide
SMILES
[Cu+].F[B-](F)(F)F.COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-]

References

General References
  1. FDA Approved Drug Products: Cardiolite (Kit for the Preparation of Technetium Tc99m Sestamibi) for injection [Link]
ChemSpider
58827688
RxNav
1306061

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedDiagnosticCoronary Artery Disease (CAD) / Type 1 Diabetes Mellitus1
3CompletedDiagnosticMucocutaneous Lymph Node Syndrome1
0RecruitingDiagnosticEstrogen Receptor Negative / HER2/Neu Negative / Progesterone Receptor Negative / Triple Negative Breast Carcinoma1
Not AvailableCompletedDiagnosticBreast Cancer2
Not AvailableTerminatedDiagnosticIschemic Heart Disease / Myocardial Infarction1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, powder, for solution; kitIntravenous1 MG
Injection, powder, lyophilized, for solutionIntravenous
Kit
Injection, powder, lyophilized, for solutionIntravenous1 mg/vial
Injection, powder, lyophilized, for solutionIntravenous1 mg/1mL
Injection, powder, lyophilized, for solutionIntravenous1 mg
Injection, powder, lyophilized, for solutionIntravenous1.5 mg/1
Injection, powder, for solutionIntravenous1.0 mg
Injection, powder, for solutionIntravenous
Injection, powder, for solutionIntravenous bolus
InjectionIntravenous1 mg/1mL
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0366 mg/mLALOGPS
logP2.94ALOGPS
logP-1.3ChemAxon
logS-3.8ALOGPS
pKa (Strongest Acidic)16.14ChemAxon
pKa (Strongest Basic)-4.2ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area13.59 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity41.61 m3·mol-1ChemAxon
Polarizability12.7 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on June 21, 2018 16:28 / Updated on February 13, 2021 10:53