Cardio-spect
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Brand Names
- Cardiolite
- Generic Name
- Tetrakis(2-methoxyisobutylisocyanide)copper(I) tetrafluoroborate
Commonly known or available as Cardio-spect - DrugBank Accession Number
- DB14106
- Background
Tetrakis (2-methoxyisobutylisocyanide) copper (I) tetrafluoroborate is a component of Cardiolite, a technetium Tc99m-based imaging agent used for assessing myocardial perfusion.1
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 602.99
Monoisotopic: 602.268772 - Chemical Formula
- C24H44BCuF4N4O4
- Synonyms
- Cardio-spect
- Tetrakis (2-methoxyisobutyl isonitrile) copper (I) tetrafluoroborate
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Diagnostic agent Angina pectoris •••••••••••• •••••••••• ••••••• ••• •••••••• Diagnostic agent Breast cancer •••••••••••• •••••••••• ••••••• ••• •••••••• Used in combination as diagnostic agent Coronary artery disease Combination Product in combination with: Technetium Tc-99m (DB14227) •••••••••••• Diagnostic agent Coronary artery disease (cad) •••••••••••• •••••••••• ••••••• ••• •••••••• Diagnostic agent Hyperparathyroidism •••••••••••• ••••••• •••••••••••••••• •••••• ••••••••••••••• •••••••••• ••••••• ••• •••••••• - Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Cardiolite Injection, powder, lyophilized, for solution 1 mg/1mL Intravenous Lantheus Medical Imaging, Inc. 1990-12-20 Not applicable US Kit for the Preparation of Technetium Tc99m Sestamibi Injection, powder, lyophilized, for solution 1 mg/1mL Intravenous Lantheus Medical Imaging, Inc. 1990-12-20 Not applicable US Sestamibi Injection, powder, lyophilized, for solution 1.5 mg/1 Intravenous Anazao Health Corporation 2012-05-23 Not applicable US - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Technetium Tc 99m Sestamibi Injection 1 mg/1mL Intravenous Curium Netherlands B.V. 2011-10-31 Not applicable US - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image STAMICIS 1 mg Kit for Radiopharmaceutical Preparation Kit 1 mg QUANTARAD TECHNOLOGIES SDN BHD 2020-09-08 2024-06-28 Malaysia - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Sestamibi Tetrakis(2-methoxyisobutylisocyanide)copper(I) tetrafluoroborate (1.5 mg/1) Injection, powder, lyophilized, for solution Intravenous Anazao Health Corporation 2012-05-23 Not applicable US
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- N6OU7HJ70P
- CAS number
- 103694-84-4
- InChI Key
- WJRFSUVOHUMYAO-UHFFFAOYSA-N
- InChI
- InChI=1S/4C6H11NO.BF4.Cu/c4*1-6(2,8-4)5-7-3;2-1(3,4)5;/h4*5H2,1-2,4H3;;/q;;;;-1;+1
- IUPAC Name
- lambda1-copper(1+) tetrakis(1-isocyano-2-methoxy-2-methylpropane) tetrafluoroboranuide
- SMILES
- [Cu+].F[B-](F)(F)F.COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-].COC(C)(C)C[N+]#[C-]
References
- General References
- FDA Approved Drug Products: Cardiolite (Kit for the Preparation of Technetium Tc99m Sestamibi) for injection [Link]
- External Links
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Completed Diagnostic Breast Cancer 2 somestatus stop reason just information to hide Not Available Terminated Diagnostic Ischemic Heart Disease / Myocardial Infarction 1 somestatus stop reason just information to hide 4 Completed Diagnostic Coronary Artery Disease (CAD) / Type 1 Diabetes Mellitus 1 somestatus stop reason just information to hide 3 Completed Diagnostic Mucocutaneous Lymph Node Syndrome 1 somestatus stop reason just information to hide 0 Active Not Recruiting Diagnostic Estrogen Receptor Negative / HER2 negative / Progesterone Receptor Negative / Triple Negative Breast Carcinoma 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection, powder, for solution; kit Intravenous 1 MG Injection, powder, lyophilized, for solution Intravenous 0.5 mg Kit 1 mg Injection, powder, lyophilized, for solution Intravenous 1 mg/vial Injection, powder, lyophilized, for solution Intravenous 1 mg/1mL Injection, powder, lyophilized, for solution Intravenous 1 mg Kit 500 Mikrogramm Kit Injection, powder, lyophilized, for solution Intravenous 1.5 mg/1 Injection, powder, for solution Intravenous 1.0 mg Injection, powder, for solution Intravenous 1 MG/vial Injection, powder, for solution Intravenous bolus 1 mg Injection Intravenous 1 mg/1mL - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0366 mg/mL ALOGPS logP 2.94 ALOGPS logP -1.3 Chemaxon logS -3.8 ALOGPS pKa (Strongest Acidic) 16.14 Chemaxon pKa (Strongest Basic) -4.2 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 13.59 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 41.61 m3·mol-1 Chemaxon Polarizability 12.7 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at June 21, 2018 16:28 / Updated at February 13, 2021 10:53