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Displaying results 1311 - 1320 of 10000 in total
  1. Pathway

    Metiamide H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0123167
    Drug action

    Metiamide is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epithe...

    Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Metiamide
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  2. Pathway

    Roxatidine Acetate H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0123168
    Drug action

    Roxatidine Acetate is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stoma...

    Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Roxatidine acetate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  3. Pathway

    Nizatidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0126776
    Drug action

    Nizatidine is an H2 Histamine receptor antagonist used to treat acid reflux disorders and a variety of ulcers. Nizatidine is taken orally as a solution or a capsule. Once it is transported to gastric basolateral membrane of parietal cell...

    Drugs: ATP · Nizatidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  4. Pathway

    Lavoltidine H2 Anti-histamine Action Pathway

    smpdb.ca/view/SMP0126790
    Drug action

    Lavoltidine has been used in trials studying the diagnostic of Reflux, Gastroesophageal and Gastroesophageal Reflux Disease. After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epi...

    Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Lavoltidine
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  5. Drug

    Agomelatine

    go.drugbank.com/drugs/DB06594
    ApprovedInvestigational

    Agomelatine was developed in Europe by Servier Laboratories Ltd. and submitted to the European Medicines Agency (EMA) in 2005. … In 2006 Servier sold the rights to develop Agomelatine in the US to Novartis. The development for the US market was discontinued in October 2011.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: VALDOXAN® 25 MG, ALODIL®25 MGTABLETARECUBIERTA
  6. Drug

    Viloxazine

    go.drugbank.com/drugs/DB09185
    ApprovedInvestigationalWithdrawn

    Viloxazine is a selective norepinephrine reuptake inhibitor.[L41685] For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant. … In the US, viloxazine was assigned an orphan drug designation in 1984 under the brand name CATATROL: while this product was intended to treat cataplexy and narcolepsy, the drug was never approved for these

    Categories: MATE 1 Inhibitors, Cytochrome P-450 SubstratesSynonyms: 2-((2-Ethoxyphenoxy)methyl)morpholine
  7. Drug

    Technetium Tc-99m pertechnetate

    go.drugbank.com/drugs/DB09314
    ApprovedInvestigational

    Pertechnetate has a wide variety of uses within nuclear medicine as it distributes within the body to a similar extent as iodine. … This is normally supplied in a hospital setting through the use of a technetium-99m generator, whereby technetium exits the generator in the form of the pertechnetate ion, TcO4−, which can be extracted

    Synonyms: Technetium Tc 99m Pertechnetate, Technetium Tc-99m pertechnetateSalts: Technetium Tc-99m sodium pertechnetate
  8. Drug

    Benserazide

    go.drugbank.com/drugs/DB12783
    ApprovedInvestigational

    In particular, although the specific levodopa/benserazide combination is formally approved for use in Canada and much of Europe, the FDA has approved another similar levodopa/dopa decarboxylase inhibitor … Moreover, the European Medcines Agency has conferred an orphan designation upon benseraside since 2015 for its potential to be used as a therapy for beta thalassaemia as well [F3].

    Mixtures: MADOPAR 125 T, MADOPAR 125 TCategories: Aromatic L-amino Acid Decarboxylase Inhibitors
  9. Drug

    Parecoxib

    go.drugbank.com/drugs/DB08439
    ApprovedInvestigational

    It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. … Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union.

    Categories: COX-2 Inhibitors, Cytochrome P-450 SubstratesSynonyms: N-((p-(5-methyl-3-phenyl-4-isoxazolyl)phenyl)sulfonyl)propionamide
  10. Pathway

    Famotidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0126789
    Drug action

    Famotidine is a histamine H2 receptor antagonist used to treat gastroesophageal reflux disease and various ulcers. Famotidine displays high selectivity towards H2 histamine receptors compared to other H2 anti-histamines. After being take...

    Drugs: ATP · Famotidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short